Resorbable Antibiotic Coatings for Bone Substitutes and Implantable Devices

Abstract

Antibiotic delivery systems based on biodegradable coatings have found considerable interest for the prophylaxis and local therapy of biomaterial-related infections. In this study sparingly watersoluble gentamicin salts have been prepared and tested as biodegradable antibiotic-releasing coating systems. Using the coating systems, homogeneous, well adhering films can be produced on various implant materials, like ceramics, glasses or metals surfaces, with different surface morphologies. The in vitro release profiles of the antibiotic coating systems were characterized by an initial burst release followed by a sustained release of small antibiotic amounts up to several weeks. It was found that the in vitro release, especially in the initial phase, can be modulated by the ratio between highly water-soluble gentamicin salts and sparingly soluble ones in the coating. Coating systems of the same type as described for gentamicin are available from a wide range of antibiotics differing in structure and mechanism of antibacterial action. Based on these results, the developed antibiotic coatings offer new perspectives to prevent and treat biomaterial-related infections.

Abstracts „Bayern Innovativ'

“…uncemented coated titanium disc: Gentamicinpalmitat und zahlreiche andere Antibiotika-/Antiseptikaverbindungen mit Fettsäuren wurden zwischenzeitlich mit Erfolg zur bakteriziden Ausrüstung von Implantaten wie zementloser Endoprothesen, Wirbelkörper, Zahnimplantate, Gefäßprothesen, Nahtmaterial und Knochenersatzstoffe eingesetzt [9], [7], [4], [5], [3] . In enger Kooperation von Universität und Industrie werden derzeit die Grundlagen für die humane Anwendung erarbeitet.…”

“…Es kommt vielmehr bei den Mikro-organismen durch Quorum-Sensing zu einer Stoffwechsel-umstellung. Die Mikroorganismen wachsen nicht mehr in einer planktonischen sondern in einer sessilen Form [1,4,7], Die MHK der Bakterien in mg/1 ist dann gegenüber Antibiotika im Vergleich zum planktonischen Wachstum um das bis zu lOOOfache höher [9], Um die Biofilmbildung zu verhindern, muss daher das Anheften von Mikroorganismen an die Fremdkörper verhindert werden. Bei der systemischen intravenösen Antibiotikaprophylaxe bzw.…”

Novel fatty acid gentamicin salts as slow-release drug carrier systems for anti-infective protection of vascular biomaterials

“…Gentamicin sodium dodecyl sulfate (Genta-SDS), gentamicin laurate (Genta-L) and gentamicin palmitate (Genta-P) were provided by Heraeus Medical GmbH, Wehrheim, Germany. Gentamicin fatty acid salts were prepared according to Vogt et al [9]. The mass percentage of gentamicin base in the respective salts was specified at 25 % for Genta-SDS, at 31 % for Genta-L and at 26 % for Genta-P. A mass of 250 mg of each gentamicin salt were solved in 15 ml of a chloroform/methanol mixture (Sigma-Aldrich AG, Deisenhofen, Germany).…”

Gentamicin Eluting 3D-Printed Implants for Preventing Post-Surgical Infections in Bone Fractures

“…Since PSIs are the primary concern in implantation failure, systemic administration of antibiotics is usually followed to treat soft and hard tissue infections. However, this is not as effective due to the poor accessibility of the infected bone regions . Bacterial adhesion is just an initial step which is a rapid and reversible interaction between bacterial and material surfaces.…”