Resorbable bioceramics based on stabilized calcium phosphates. Part II: evaluation of biological response

Langstaff, S.; Sayer, M.; Smith, Thomas; Pugh, S

doi:10.1016/s0142-9612(00)00139-3

Cited by 176 publications

(164 citation statements)

References 14 publications

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“…Through evaluation of the thickness of the scaffold walls a remarkable resorption of the biomaterial was determined especially in the 4-and 6-month implants. Langstaff et al (2001) reported that silicon stabilized calcium phosphate ceramics are not soluble in biological media, but they are resorbable, when acted on by osteoclasts. In agreement also with the results in Mastrogiacomo et al (2006), from the above reported findings we propose that the presence of bone forming cells attract osteoclasts, which in turn progressively resorb the scaffold creating space to new bone to be deposited.…”

Section: Discussionmentioning

confidence: 99%

Kinetics of in vivo bone deposition by bone marrow stromal cells within a resorbable porous calcium phosphate scaffold: An X‐ray computed microtomography study

Papadimitropoulos

Mastrogiacomo

Peyrin

et al. 2007

Biotech & Bioengineering

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Resorbable ceramic scaffolds based on Silicon stabilized tricalcium phosphate (Si-TCP) were seeded with bone marrow stromal cells (BMSC) and ectopically implanted for 2, 4, and 6 months in immunodeficient mice. Qualitative and quantitative evaluation of the scaffold material was performed by X-ray synchrotron radiation computed microtomography (microCT) with a spatial resolution lower than 5 mm. Unique to these experiments was that microCT data were first collected on the scaffolds before implantation and then on the same scaffolds after they were seeded with BMSC, implanted in the mice and rescued after different times. Volume fraction, mean thickness and thickness distribution were evaluated for both new bone and scaffold phases as a function of the implantation time. New bone thickness increased from week 8 to week 16. Data for the implanted scaffolds were compared with those derived from the analysis of the same scaffolds prior to implantation and with data derived from 100% hydroxyapatite (HA) scaffold treated and analyzed in the same way. At variance with findings with the 100% HA scaffolds a significant variation in the density of the different Si-TCP scaffold regions in the pre-and post-implantation samples was observed. In particular a post-implantation decrease in the density of the scaffolds, together with major changes in the scaffold phase composition, was noticeable in areas adjacent to newly formed bone. Histology confirmed a better integration between new bone and scaffold in the Si-TCP composites in comparison to 100% HA composites where new bone and scaffold phases remained well distinct.

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Section: Discussionmentioning

confidence: 99%

Kinetics of in vivo bone deposition by bone marrow stromal cells within a resorbable porous calcium phosphate scaffold: An X‐ray computed microtomography study

Papadimitropoulos

Mastrogiacomo

Peyrin

et al. 2007

Biotech & Bioengineering

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“…From the chemical composition point of view, the vast majority of calcium orthophosphate bioceramics is based on HA, β-TCP, α-TCP and/or biphasic calcium phosphate (BCP). BCP is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) [127][128][129][130][131][132][133][134][135][136]. One should note that recently the concept of BCP has been extended by preparation and characterization of biphasic TCP (BTCP), consisting of both α-TCP and β-TCP phases [137][138][139][140][141].…”

Section: Chemical Composition and Preparationmentioning

confidence: 99%

“…Furthermore, submicron-sized HA powders are biodegraded even faster than the highly porous HA scaffolds. Other examples of bioresorbable materials include porous bioceramic scaffolds made of BCP (which is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) or bone grafts (dense or porous) made of CDHA [152], TCP [411,596,597] and/or ACP [462,598]. One must stress that recently the concepts of bioactive and bioresorbable materials have converged and bioactive materials are made bioresorbable, while bioresorbable materials are made bioactive [599].…”

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Although the exact mechanisms responsible for their good biocompatibility are still the subject of intense investigation, it has been shown that calcium phosphate ceramics undergo resorption, subsequent remodeling, and biomineralization. [10][11][12][13][14][15] More specifically, it is the increased local concentration of calcium and a͒ Author to whom correspondence should be addressed; Present address: Molecular and Health Technologies, CSIRO, Bag 10, Clayton South MDC, VIC 3169, Australia; electronic mail: ping.peng@csiro.au phosphate ions from the resorbing calcium phosphates that is considered to be conducive to new bone formation. 16 The concurrent release of calcium and phosphate ions as well as bioactive molecules such as growth factors may offer additional possibilities for the control of orthopaedic wound healing.…”

Section: Introductionmentioning

confidence: 99%

Concurrent elution of calcium phosphate and macromolecules from alginate/chitosan hydrogel coatings

et al. 2008

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The concurrent release of calcium phosphate and biomacromolecules may improve wound healing responses at the interface with ceramic materials of orthopaedic and dental implants. Hydrogel coatings consisting of a mixture of alginate and chitosan were doped and applied onto solid carriers with the aim of investigating their use as local delivery vehicles. Coatings containing both the model macromolecule FITC-dextran 70 kDa (FD 70) and dispersed calcium phosphate carbonate (CPC) nanoparticles were coated onto a solid, nonporous model substrate to study the concurrent release of FD 70 and calcium and phosphate ions from within the hydrogel. Hydrogel coatings containing only FD 70 were cast onto porous calcium phosphate coatings, similar to hydroxyapatite, to study the release of FD 70 from, and calcium and phosphate ions through, the hydrogel coating. Transmission electron microscopy showed good dispersion of the CPC nanoparticles, and scanning electron microscopy and atomic force microscopy showed that increased CPC loading resulted in an increase in surface roughness but to extents well below those affecting cell responses. The release of FD 70 from CPC-loaded coatings was similar to release from the hydrogel alone, although higher CPC loadings resulted in small changes. The release of FD 70 was better described by double or triple phase zero order release kinetics; this complex time dependence indicates that in addition to outdiffusion, other, time-dependent factors apply, such as swelling of the gel, as expected from the known effects of calcium ions on alginate. Calcium and phosphate ions were also released, with similar release kinetics, through the hydrogel layer from the underlying CaP layer. In either case, release decreased to negligible levels after 3 days, suggesting that the systems of this study are suitable for short-term concurrent release of water-soluble biomacromolecules and calcium and phosphate ions.

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Resorbable bioceramics based on stabilized calcium phosphates. Part II: evaluation of biological response

Cited by 176 publications

References 14 publications

Kinetics of in vivo bone deposition by bone marrow stromal cells within a resorbable porous calcium phosphate scaffold: An X‐ray computed microtomography study

Kinetics of in vivo bone deposition by bone marrow stromal cells within a resorbable porous calcium phosphate scaffold: An X‐ray computed microtomography study

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Concurrent elution of calcium phosphate and macromolecules from alginate/chitosan hydrogel coatings

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