Resorbable Polymer-Ceramic Composites for Orthopedic Scaffold Applications

Vaidyanathan, Ranji; Hecht, Bert; Studley, A.; Phillips, Tristan; Calvert, Paul; Tellis, B. C.; Coleman, Anita Sundaram; Szivek, John A.

doi:10.1002/9780470291191.ch80

Cited by 6 publications

(3 citation statements)

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“…Polybutylene terephthalate (PBT) scaffolds were manufactured using an extrusion freeform fabrication rapid prototyping process, which has previously been reported 17. A grid pattern formed with PBT, which had been noted to develop good bone ingrowth in a previous study,18 was modified slightly so that strands within the scaffold were rotated 45° between layers (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

An instrumented scaffold can monitor loading in the knee joint

et al. 2006

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No technique has been consistently successful in the repair of large focal defects in cartilage, particularly in older patients. Tissue-engineered cartilage grown on synthetic scaffolds with appropriate mechanical properties will provide an implant, which could be used to treat this problem. A means of monitoring loads and pressures acting on cartilage, at the defect site, will provide information needed to understand integration and survival of engineered tissues. It will also provide a means of evaluating rehabilitation protocols. A "sensate" scaffold with calibrated strain sensors attached to its surface, combined with a subminiature radio transmitter, was developed and utilized to measure loads and pressures during gait. In an animal study utilizing six dogs, peak loads of 120N and peak pressures of 11 MPa were measured during relaxed gait. Ingrowth into the scaffold characterized after 6 months in vivo indicated that it was well anchored and bone formation was continuing. Cartilage tissue formation was noted at the edges of the defect at the joint-scaffold interfaces. This suggested that native cartilage integration in future formulations of this scaffold configured with engineered cartilage will be a possibility.

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Section: Methodsmentioning

confidence: 99%

An instrumented scaffold can monitor loading in the knee joint

et al. 2006

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“…A three‐dimensional (3D) porous PBT scaffold design was created on a CAD program (SolidWorks, Concord, MA) using a previously reported method 45. Cylindrical scaffolds (9.5 mm diameter) had a domed top, where the radius of curvature (8 mm) of the flattened dome was chosen to approximate the curvature of the medial femoral condyle [Figure 1(A)].…”

Section: Methodsmentioning

confidence: 99%

Sensate scaffolds can reliably detect joint loading

et al. 2006

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Treatment of cartilage defects is essential to the prevention of osteoarthritis. Scaffold-based cartilage tissue engineering shows promise as a viable technique to treat focal defects. Added functionality can be achieved by incorporating strain gauges into scaffolds, thereby providing a real-time diagnostic measurement of joint loading. Strain-gauged scaffolds were placed into the medial femoral condyles of 14 adult canine knees and benchtop tested. Loads between 75 and 130 N were applied to the stifle joints at 30°, 50°, and 70° of flexion. Strain-gauged scaffolds were able to reliably assess joint loading at all applied flexion angles and loads. Pressure sensitive films were used to determine joint surface pressures during loading and to assess the effect of scaffold placement on joint pressures. A comparison of peak pressures in control knees and joints with implanted scaffolds, as well as a comparison of pressures before and after scaffold placement, showed that strain-gauged scaffold implantation did not significantly alter joint pressures. Future studies could possibly use straingauged scaffolds to clinically establish normal joint loads and to determine loads that are damaging to both healthy and tissue-engineered cartilage. Strain-gauged scaffolds may significantly aid the development of a functional engineered cartilage tissue substitute as well as provide insight into the native environment of cartilage.

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“…Poly(lactic acid) (PLA), a biodegradable thermoplastic either derived from renewable sources or synthetic, finds diverse applications in biomedicine [1][2][3][4][5][6][7][8][9][10]. It is utilized for surgical implants, drug delivery systems, tissue engineering, dental applications, sutures, orthopedic devices, wound dressings, diagnostic devices, and medical equipment, showcasing its biocompatibility and versatility.…”

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Hybrid Radiant Disinfection: Exploring UVC and UVB Sterilization Impact on the Mechanical Characteristics of PLA Materials

Aboamer,

Alsuayri,

Alassaf

et al. 2023

Polymers

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This study explores the impact of disinfection techniques on the mechanical properties of poly(lactic acid) (PLA), a crucial material in the production of medical implants, tissue engineering, orthopedic devices and drug delivery systems, owing to its biocompatibility and ease of manufacturing. The focus is on evaluating the effectiveness of ultraviolet (UV) type C (254 nm wavelength) and the combined use of type C and B (310 nm wavelength) disinfection methods. Fifteen tensile test specimens (ASTM D638) and fifteen compression test specimens (ASTM D695) were utilized to assess PLA’s mechanical properties, including yield strength, ultimate strength, and fracture strength. The investigation involved subjecting the specimens to the specified disinfection methods and evaluating these properties both before and after the disinfection process. In the tensile test, a statistically significant difference (p = 0) in yield displacement was observed among the three groups. Additionally, a notable difference (p = 0.047) in fracture displacement was identified between the untreated group and the UVC and UVB combination group. No discernible impact on yield or fracture forces was noted. In the compression test, there was a significant difference (p = 0.04) in yield displacement and a clear difference (p = 0.05) in fracture force between the untreated group and the UVC and UVB combination group. The hybrid combination of UVC and UVB disinfection techniques did not affect yield force in both tensile and compression tests. However, it demonstrated a clear impact on displacement, suggesting its potential as a promising disinfection technique in the medical field.

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Resorbable Polymer-Ceramic Composites for Orthopedic Scaffold Applications

Cited by 6 publications

References 0 publications

An instrumented scaffold can monitor loading in the knee joint

An instrumented scaffold can monitor loading in the knee joint

Sensate scaffolds can reliably detect joint loading

Hybrid Radiant Disinfection: Exploring UVC and UVB Sterilization Impact on the Mechanical Characteristics of PLA Materials

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