Resorbable Synthetic Bone Grafts Formed From a Silicon Stabilized Calcium Phosphate Bioceramic

Langstaff, S.; Sayer, M.; Smith, Thomas; Pugh, S

doi:10.1557/proc-550-313

Cited by 6 publications

(8 citation statements)

References 5 publications

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“…Combined substitution of Sr and Mg causes reduction in the unit cell parameters of the crystal lattice [17]. Si 4+ is not substituted for Ca 2+ in the crystal lattice of TCP; rather it is substituted for P 5+ [45, 46]. The substitution of P 5+ by Si 4+ addresses the increased grain size due to the presence of SiO 2 as ionic radius of Si 4+ (2.71 Å) is higher than that of P 5+ (1.28 Å).…”

Section: Discussionmentioning

confidence: 99%

Understanding in vivo response and mechanical property variation in MgO, SrO and SiO2 doped β-TCP

Bose

Tarafder

Banerjee

et al. 2011

Bone

145

130

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The aim of this work is to evaluate the influence of MgO, SrO and SiO2 doping on mechanical and biological properties of β-tricalcium phosphate (β-TCP) to achieve controlled resorption kinetics of β-TCP system for maxillofacial and spinal fusion application. We prepared dense TCP compacts of four different compositions, i) pure β-TCP, ii) β-TCP with 1.0 wt. % MgO + 1.0 wt. % SrO, iii) β-TCP with 1.0 wt. % SrO + 0.5 wt. % SiO2, and iv) β-TCP with 1.0 wt. % MgO + 1.0 wt. % SrO + 0.5 wt. % SiO2, by uniaxial pressing and sintering at 1250 °C. β phase stability is observed at 1250 °C sintering temperature due to MgO doping in β-TCP. In vitro mineralization in simulated body fluid (SBF) for 16 weeks shows excellent apatite growth on undoped and doped samples. Strength degradation of TCP samples in SBF is significantly influenced by both dopant chemistry and amount of dopant. Compressive strengths for all samples show degradation in SBF over the 16 week time period with varying degradation kinetics. MgO/SrO/SiO2 doped sample shows no strength loss, while undoped TCP shows the maximum strength loss from 419 ±28 MPa to 158 ±28 MPa over the 16 week study. In case of MgO/SrO doped TCP, strength loss is slow and gradual. TCP doped with 1.0 wt. % MgO and 1.0 wt. % SrO shows excellent in vivo biocompatibility when tested in male Sprague-Dawley rats for 16 weeks. Histomorphology analysis reveals that MgO/SrO doped TCP promoted osteogenesis by excellent early stage bone remodeling as compared to undoped TCP.

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Section: Discussionmentioning

confidence: 99%

Understanding in vivo response and mechanical property variation in MgO, SrO and SiO2 doped β-TCP

Bose

Tarafder

Banerjee

et al. 2011

Bone

145

130

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“…Since approximately the mid‐1990s, silicon‐containing and/or silicon–substituted calcium phosphates (Si–CaP) have received increasing attention from researchers and, even more recently, clinicians .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] Since approximately the mid-1990s, silicon-containing and/ or silicon-substituted calcium phosphates (Si-CaP) have received increasing attention from researchers and, even more recently, clinicians. [5][6][7][8][9][10][11][12] As discovered recently, silicon plays a special and unique role in the process of biological mineralization of bone. 13,14 On the other hand, 39 years have already passed since the invention of biologically active glasses (e.g., Bioglass; they also contain silicon) and their ability to be accepted by human body.…”

Section: Introductionmentioning

confidence: 99%

The Sub‐System α‐TCP_ss‐Silicocarnotite Within the Binary System Ca₃(PO₄)₂–Ca₂SiO₄

2012

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Silicon (Si) influences the biologic activity of calcium phosphate materials by modifying material properties and by direct effects on the physiological processes in skeletal tissue. Compositions belonging to the system dicalcium silicate (Ca2SiO4 = C2S)‐tricalcium phosphate (Ca3(PO4)2 = TCP), able to release that element in situ, are promising candidates for preparing new ceramic bone implants. An exact knowledge of the phase relationships in the system is required to design materials with controlled phase compositions and properties. Thus, a study of the sub‐system α‐TCPss‐Silicocarnotite within the C2S–TCP system was studied as a preliminary step toward obtaining new monophasic and/or biphasic bioceramics. Phase composition of the resulting ceramics was studied using X‐ray diffraction and scanning electron microscopy with attached wavelength dispersive spectrometer. The results showed that the sub‐system presents an invariant eutectoid point at 1158°C ± 2°C for a composition of 83 wt% Ca3(PO4)2 and 17 wt% Ca2SiO4, and typical eutectoid microstructure of lamellae morphology.

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“…Since approximately the mid‐1990s, silicon containing and/or silicon‐substituted calcium phosphates (Si‐CaP) have received increasing attention from researchers and, even more recently, clinicians 7–16 . As discovered recently, silicon plays a special and unique role in the process of biological mineralization of collagen 17 .…”

Section: Introductionmentioning

confidence: 99%

In Vitro Mineralization of Silicon Containing Calcium Phosphate Bioceramics

Dorozhkin¹

2006

Journal of the American Ceramic Society

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In vitro mineralization of silicon containing calcium phosphate (Si‐CaP) bioceramics was investigated in the constant‐composition double‐diffusion (CCDD) device under physiological conditions. The experiments were performed with porous pellets made of Si‐CaP, which was synthesized from Ca(NO3)2·4H2O, NH4H2PO4, ammonia and fumed silica according to a newly developed single‐stage preparation route. Twice as condensed aqueous solutions of the Kokubo's revised simulated body fluid (rSBF) were used as mineralizing medium. All samples of Si‐CaP bioceramics possessed excellent in vitro mineralizing properties and, therefore, this material is ready for further trials with cells. Simultaneously, the workability of the CCDD device in a less condensed (twofold instead of the previously used fourfold) aqueous solutions of rSBF was confirmed.

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Resorbable Synthetic Bone Grafts Formed From a Silicon Stabilized Calcium Phosphate Bioceramic

Cited by 6 publications

References 5 publications

Understanding in vivo response and mechanical property variation in MgO, SrO and SiO2 doped β-TCP

Understanding in vivo response and mechanical property variation in MgO, SrO and SiO2 doped β-TCP

The Sub‐System α‐TCP_ss‐Silicocarnotite Within the Binary System Ca₃(PO₄)₂–Ca₂SiO₄

In Vitro Mineralization of Silicon Containing Calcium Phosphate Bioceramics

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Resorbable Synthetic Bone Grafts Formed From a Silicon Stabilized Calcium Phosphate Bioceramic

Cited by 6 publications

References 5 publications

Understanding in vivo response and mechanical property variation in MgO, SrO and SiO2 doped β-TCP

Understanding in vivo response and mechanical property variation in MgO, SrO and SiO2 doped β-TCP

The Sub‐System α‐TCPss‐Silicocarnotite Within the Binary System Ca3(PO4)2–Ca2SiO4

In Vitro Mineralization of Silicon Containing Calcium Phosphate Bioceramics

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The Sub‐System α‐TCP_ss‐Silicocarnotite Within the Binary System Ca₃(PO₄)₂–Ca₂SiO₄