Resorption of calcification in primary pulmonary tuberculosis

Morrison, John

doi:10.1136/thx.25.6.643

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Typical nonmalignant lung disease often develops during the healing of infectious granulomatous disease. 6 Calcification within lung nodule shadows is considered negative for malignant tumors, but does occur rarely; for example, if lung cancer occurs near a calcified benign tumor. 1,7 Calcification occurs with amorphous (small-cell lung cancer), punctate (squamous cell carcinoma), or reticular patterns.…”

Section: Discussionmentioning

confidence: 99%

Extensive calcification in adenocarcinoma of the lung: A case report

et al. 2020

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Calcification in lung nodules usually indicates a benign lesion. Here, we report the case of a 59-year-old male patient with a well defined 30 mm calcified nodule in his right upper lung lobe and calcified mediastinal lymph nodes. The mass was diagnosed as adenocarcinoma by transbronchial biopsy. He received systemic chemotherapy, followed by lobectomy and mediastinal lymph node dissection. During surgery, the lymph nodes were tightly adherent to the superior vena cava with invasion of the vascular wall. Pathological diagnosis confirmed acinar adenocarcinoma and psammoma bodies (PBs). Immunohistochemical analysis revealed tumor cells positive for parathyroid hormone-related proteins 1 and 2. Calcification of primary lung adenocarcinoma is rare. We report a calcified lesion where the secretion of parathyroid hormone by the tumor may have caused the accumulation of PBs. Calcification of metastatic lymph nodes may increase the risk of adhesion, requiring care during surgery.

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Section: Discussionmentioning

confidence: 99%

Extensive calcification in adenocarcinoma of the lung: A case report

et al. 2020

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“…The clearing of calcification in whole or in part from the lungs and/or lymph nodes of 68 children is a most interesting finding, which has been discussed in detail elsewhere (Morrison, 1970). In brief, by 1968 full clearing of calcification had occurred from the lungs of 24 children and from the lymph nodes of 13 children, and partial clearing had occurred from the lungs of 17 children and from the lymph nodes of 14 children.…”

Section: Final Resultsmentioning

confidence: 88%

Natural history of segmental lesions in primary pulmonary tuberculosis: long-term review of 383 patients.

Morrison¹

1973

Archives of Disease in Childhood

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“…Mtb can trigger formation of calcium deposits that are mostly dystrophic, occurring in coagulative, caseous, and liquefactive necrotic tissue (Morrison, 1970). While calcification is not specific to Mtb infection, this process is indicative of healing although the mechanism(s) of deposition is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions

et al. 2022

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Our current understanding of the spectrum of TB and COVID-19 lesions in the human lung is limited by a reliance on lowresolution imaging platforms that cannot provide accurate 3D representations of lesion types within the context of the whole lung. To characterize TB and COVID-19 lesions in 3D, we applied micro/nanocomputed tomography to surgically resected, postmortem, and paraffin-embedded human lung tissue. We define a spectrum of TB pathologies, including cavitary lesions, calcium deposits outside and inside necrotic granulomas and mycetomas, and vascular rearrangement. We identified an unusual spatial arrangement of vasculature within an entire COVID-19 lobe, and 3D segmentation of blood vessels revealed microangiopathy associated with hemorrhage. Notably, segmentation of pathological anomalies reveals hidden pathological structures that might otherwise be disregarded, demonstrating a powerful method to visualize pathologies in 3D in TB lung tissue and whole COVID-19 lobes. These findings provide unexpected new insight into the spatial organization of the spectrum of TB and COVID-19 lesions within the framework of the entire lung.

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Resorption of calcification in primary pulmonary tuberculosis

Cited by 5 publications

References 6 publications

Extensive calcification in adenocarcinoma of the lung: A case report

Extensive calcification in adenocarcinoma of the lung: A case report

Natural history of segmental lesions in primary pulmonary tuberculosis: long-term review of 383 patients.

A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions

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