Resource Allocation in COVID-19 Research: Which Trials? Which Patients?

Wieten, Sarah; Burgart, Alyssa M.; Cho, Mildred

doi:10.1080/15265161.2020.1779392

Cited by 10 publications

(8 citation statements)

References 8 publications

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“…Finally, when multiple research teams require participants, triage committees are needed to direct recruitment away from low priority, duplicative, or underpowered trials with little potential for usable findings 1315. Institutions must guarantee that patients with covid-19 are informed of all available trial options and assured autonomy in their decisions about participation 15…”

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confidence: 99%

Convalescent plasma is ineffective for covid-19

Pathak

2020

BMJ

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confidence: 99%

Convalescent plasma is ineffective for covid-19

Pathak

2020

BMJ

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“…As far as research is concerned, significant challenges have been encountered in terms of the planning of clinical research designs, sourcing of funding for research as research priorities change, as well as significant questions around ethical clearance of studies conducted during the COVID-19 pandemic. Questions around ethical clearance have had ethical committees and institutional research review boards challenged by their mandate to facilitate ethical research whilst adhering to health and safety regulations implemented to protect and safeguard the safety of research participants and researchers (Beach et al, 2020 ; Lumeng et al, 2020 ; Perez et al, 2020 ; Sebothoma et al, 2021 ; Wieten, Burgart, & Cho, 2020 ). Weiner, Balasubramaniam, Shah and Javier ( 2020 ) believed that the impact that the COVID-19 pandemic had on general research and on research specific to the pandemic raises numerous important factors: (1) the significance of research, (2) challenges of research, especially during public health emergencies (PHEs) and (3) resources and opportunities towards improving research to become more efficient and cost effective.…”

Section: Introductionmentioning

confidence: 99%

Conducting clinical research in the era of the COVID-19 pandemic: Challenges and lessons for Speech-Language Pathology and Audiology research

Khoza-Shangase

Monroe

Sebothoma

2022

SAJCD

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Background: The novel coronavirus disease 2019 (COVID-19) presented new and unanticipated challenges to the academic training and performance of clinical research at undergraduate and postgraduate levels of training. This highlighted the need for reimagining research designs and methods to ensure continued generation of knowledge – a core function of a research-intensive university. Whilst adhering to government regulations geared towards protecting both the research participants and researchers, innovative research methods are required.Objective: The purpose of this scoping review is to explore published evidence on innovative clinical research methods and processes employed during COVID-19 and to document challenges encountered and lessons that the fields of Speech-Language Pathology and Audiology can learn.Methods: Electronic bibliographic databases including Science Direct, PubMed, Scopus, MEDLINE, ProQuest were searched to identify peer-reviewed publications, published in English, between 2019 and 2021, related to innovative clinical research methods and processes applied where in-person contact is regulated.Results: Significant challenges with conducting research in the COVID-19 era were identified, with important lessons learned and numerous opportunities that have relevance for this pandemic era and beyond. These findings are presented under 10 themes that emerged that highlight important considerations for research methods and processes during a pandemic and beyond. The findings of this study also raise implications for telehealth from which low- and middle-income countries (LMICs), where resource challenges exist, can benefit.Conclusion: Challenges and opportunities identified in this review have relevance for the field of Speech-Language Pathology and Audiology as far as current and future (beyond COVID-19) clinical research planning is concerned.

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“… 17 Non-COVID-19 studies are also disadvantaged in terms of the enhanced participant recruitment for COVID-19 studies. 11 , 18 Non-COVID-19 studies and non-COVID-19 diseases have therefore been indirectly judged as less important.…”

Section: Discussionmentioning

confidence: 99%

How COVID-19 changed clinical research strategies: a global survey

Bauer¹,

Eskat

Ntekim

et al. 2022

J Int Med Res

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Objective Clinical research has faced new challenges during the COVID-19 pandemic, leading to excessive operational demands affecting all stakeholders. We evaluated the impact of COVID-19 on clinical research strategies and compared different adaptations by regulatory bodies and academic research institutions in a global context, exploring what can be learned for possible future pandemics. Methods We conducted a cross-sectional online survey and identified and assessed different COVID-19-specific adaptation strategies used by academic research institutions and regulatory bodies. Results All 19 participating academic research institutions developed and followed similar strategies, including preventive measures, manpower recruitment, and prioritisation of COVID-19 projects. In contrast, measures for centralised management or coordination of COVID-19 projects, project preselection, and funding were handled differently amongst institutions. Regulatory bodies responded similarly to the pandemic by implementing fast-track authorisation procedures for COVID-19 projects and developing guidance documents. Quality and consistency of the information and advice provided was rated differently amongst institutions. Conclusion Both academic research institutions and regulatory bodies worldwide were able to cope with challenges during the COVID-19 pandemic by developing similar strategies. We identified some unique approaches to ensure fast and efficient responses to a pandemic. Ethical concerns should be addressed in any new decision-making process.

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Resource Allocation in COVID-19 Research: Which Trials? Which Patients?

Cited by 10 publications

References 8 publications

Convalescent plasma is ineffective for covid-19

Convalescent plasma is ineffective for covid-19

Conducting clinical research in the era of the COVID-19 pandemic: Challenges and lessons for Speech-Language Pathology and Audiology research

How COVID-19 changed clinical research strategies: a global survey

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