This study discusses key characteristics and limitations of time-domain reflectometry (TDR) systems based on the Hermitian symmetric orthogonal frequency-division multiplexing (HS-OFDM) scheme for power line sensing. In this sense, a system model with a power line modem injecting signals and capturing raising reflections for sensing a power distribution network is outlined. Next, pulse compression and channel estimation reflectogram processing approaches are carefully described and the effects of system parametrization and multiple access schemes on the HS-OFDM-based TDR system performance are addressed. Finally, numerical results covering a comparison between pulse compression and channel estimation, system limitations based on parametrization considering typical European underground low-voltage and US overhead medium-voltage (MV) scenarios and narrowband (NB) power line communication (PLC) regulatory constraints, and comparison among multiple access techniques in a Brazilian MV overhead scenario are presented for supporting the carried out discussion. Based on the attained results, it is shown that channel estimation outperforms the pulse compression in terms of computational complexity and sidelobe level. Also, it is shown that the NB-PLC frequency range provides fair range resolution and maximum unambiguous range values. Finally, it is seen that the use of the frequencydivision multiple access multiple access schemes presents different signal-to-interference-plus-noise ratio (SINR) performance among different power line modems (PLMs) connected to a power distribution grid, while the use of time-division multiple access and code-division multiple access schemes results in fair SINR performance among the PLMs at the cost of obtaining less reflectograms over time due to time multiplexing and spreading processes, respectively.