Resource allocation in utero and health in later life

Barker, David J.; Lampl, Michelle; Roseboom, Tessa J.; Winder, Nicola

doi:10.1016/j.placenta.2012.06.009

Cited by 71 publications

(51 citation statements)

References 33 publications

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“…This has been shown for cardiovascular diseases, hypertension, obesity, type 2 diabetes, and metabolic syndrome as well as renal diseases, such as albuminuria and chronic kidney disease (5,9).…”

Section: Discussionmentioning

confidence: 82%

“…In fact, nephron numbers are lower in IUGR neonates. One hypothesis is that when challenged by limited resources, energy resource allocation is prioritized for brain, cardiac, and adrenal growth, whereas organs such as the kidneys and lungs receive lower priority (5). This allocation process is thought to be the root mechanism by which relative brain sparing and increased compromise in nonprotected organs takes place.…”

Section: Discussionmentioning

confidence: 99%

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Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

Pereira

Oliveira

Tavares

et al. 2015

American Journal of Physiology-Renal Physiology

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Pereira SP, Oliveira PJ, Tavares LC, Moreno AJ, Cox LA, Nathanielsz PW, Nijland MJ. Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation. Am J Physiol Renal Physiol 308: F1217-F1228, 2015. First published March 11, 2015 doi:10.1152/ajprenal.00419.2014.-Early life malnutrition results in structural alterations in the kidney, predisposing offspring to later life renal dysfunction. Kidneys of adults who were growth restricted at birth have substantial variations in nephron endowment. Animal models have indicated renal structural and functional consequences in offspring exposed to suboptimal intrauterine nutrition. Mitochondrial bioenergetics play a key role in renal energy metabolism, growth, and function. We hypothesized that moderate maternal nutrient reduction (MNR) would adversely impact fetal renal mitochondrial expression in a well-established nonhuman primate model that produces intrauterine growth reduction at term. Female baboons were fed normal chow diet or 70% of control diet (MNR). Fetal kidneys were harvested at cesarean section at 0.9 gestation (165 days gestation). Human Mitochondrial Energy Metabolism and Human Mitochondria Pathway PCR Arrays were used to analyze mitochondrially relevant mRNA expression. In situ protein content was detected by immunohistochemistry. Despite the smaller overall size, the fetal kidney weight-to-body weight ratio was not affected. We demonstrated fetal sex-specific differential mRNA expression encoding mitochondrial metabolite transport and dynamics proteins. MNRrelated differential gene expression was more evident in female fetuses, with 16 transcripts significantly altered, including 14 downregulated and 2 upregulated transcripts. MNR impacted 10 transcripts in male fetuses, with 7 downregulated and 3 upregulated transcripts. The alteration in mRNA levels was accompanied by a decrease in mitochondrial protein cytochrome c oxidase subunit VIc. In conclusion, transcripts encoding fetal renal mitochondrial energy metabolism proteins are nutrition sensitive in a sex-dependent manner. We speculate that these differences lead to decreased mitochondrial fitness that contributes to renal dysfunction in later life. mitochondria; kidney; fetal programming; nonhuman primate; gene expression SUBOPTIMAL PRENATAL DEVELOPMENT predisposes to adult onset diseases such as hypertension, diabetes, cardiovascular, and renal disease (2,9,42,64). Importantly, there is clear evidence that the developing nonhuman primate kidney is sensitive to decreased maternal nutrition (45). Poor intrauterine nutrition is associated with reduced nephron number in both animals and humans (29,35,41,62). Analysis of renal autopsies of adults born with low birth weight has shown substantial variations in renal composition (26). Remarkably, little attention has been given to the possible involvement of mitochondria as putative mediators between maternal nutrient reduction (MNR) and altered renal development in their offspring. This is surpr...

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

Pereira

Oliveira

Tavares

et al. 2015

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

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“…The current hypothesis on the fetal origin of later-life chronic diseases suggests that exposure of the fetus to an adverse environment, including malnutrition, predisposes a person to later life chronic diseases, such as cardiovascular diseases, hypertension, diabetes and obesity (1,2). Birth weight is one of the most important predictors of fetal survival and health.…”

Section: Introductionmentioning

confidence: 99%

“…The birth weight of a baby depends not only on the mother's nutrition but also on the placenta's ability to transport nutrients to it from its mother (2). Placental weight and volume can predict pregnancy outcome and thus the future health of the newborn (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…For example, placental size and shape has been reported to predict blood pressure at age 9 years (15). Thus, the shape and size of the placenta at birth has become a new marker for pregnancy outcome and for chronic disease in later life (2). It has been reported that placental characteristics are not only influenced by neonatal, nutritional and environmental factors (16)(17)(18), but also by ethnicity (19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy outcome variables and associated factors in different nationalities living in Kuwait

Rahman

Al-Rashidi

Akhtar

2017

East Mediterr Health J

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Différences en matière d'issues de grossesse et leurs prédicteurs entre les diverses nationalités résidant au KoweïtRÉSUMÉ La présente étude visait à analyser les différences en matière d'issue de grossesse entre les différentes nationalités résidant au Koweït. Des données transversales ont été recueillies auprès de 369 dyades mère-nouveauné au moment de l'accouchement sur la taille de la mère, l'hémoglobine (Hb) maternelle, l'hémoglobine de l'enfant (Hbe), le périmètre brachial (PB), l'âge gestationnel, le poids du placenta (PP), le poids de naissance (PN), la taille vertex-talon (TVT), et le périmètre crânien (PC). Des différences significatives ont été observées entre les diverses nationalités en ce qui concerne l'Hb maternelle, le PC, le LVT, le PP et la taille de la mère. Les femmes koweïtiennes et indiennes présentaient un PP plus faible et leurs bébés avaient un PC et une TVT inférieures. La prévalence de l'anémie (Hb <11,0 g/dL) était comprise entre 7,1 % (Libanaises) et 30,0 % (Koweïtiennes) avec une prévalence globale de 19,5 %. La prévalence du faible poids de naissance était de 3,5 %. L'analyse de régression linéaire multiple a révélé que le PP constituait un facteur prédictif pour le PN, la LVT et le PC. Des différences significatives ont été observées entre les diverses nationalités en termes d'Hb maternelle, de PC, de LVT, de PP et de taille de la mère. L'importance de ces différences et les facteurs qui y contribuent nécessitent des recherches supplémentaires. ABSTRACT This study aimed to investigate differences in pregnancy outcome among various nationalities residing in Kuwait. Cross-sectional data were collected from 369 mother-infant dyads at delivery on mother height (MH), mother haemoglobin (mHb), child haemoglobin (cHb), mid-upper arm circumference (MUAC), gestational age (GA), placental weight (PW), birth weight (BW), crown-heal length (CHL), and head circumference (HC). Significant differences among various nationalities were observed in mHb, HC, CHL, PW and MH. Kuwaiti and Indian women had lower PW and their babies had lower HC and CHL. Prevalence of anaemia (Hb <11.0 g/dL) ranged from 7.1% (Lebanese) to 30.0% (Kuwaiti) with the overall prevalence of 19.5%. Prevalence of low birth weight was 3.5%. Multiple linear regression analysis revealed PW as a significant predictor of BW, CHL and HC. Significant differences among various nationalities were observed in mHb, HC, CHL, PW and MH.The significance of these differences and their contributing factors needs further research. ‫الكويت‬ ‫يف‬ ‫املقيمة‬ ‫املختلفة‬ ‫اجلنسيات‬ ‫بني‬ ‫ومنبئاته‬ ‫احلمل‬ ‫نتائج‬ ‫يف‬ ‫االختالفات‬

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The Mother-Infant Nexus in Anthropology

2020

Bioarchaeology and Social Theory

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Post-Medieval London (16 th -19 th centuries) was a stressful environment in which to be poor.Overcrowded and squalid housing, physically demanding and risky working conditions, air and water pollution, inadequate diet, and exposure to infectious diseases created high levels of morbidity and low life expectancy. All of these factors pressed with particular severity on the lowest members of the social strata, with burgeoning disparities in health between the richest and poorest. Fetal, perinatal and infant skeletal remains provide the most sensitive source of bioarchaeological information regarding past population health and in particular maternal wellbeing. This chapter examined evidence for chronic growth and health disruption in 136 fetal, perinatal and infant skeletons from four low status cemetery samples in post-Medieval London.The aim of this study was to consider the impact of poverty on the maternal/infant nexus, through an analysis of evidence of growth disruption and pathological lesions. The results highlight the dire consequences of poverty in London during this period from the very earliest moments of life.

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Resource allocation in utero and health in later life

Cited by 71 publications

References 33 publications

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

Pregnancy outcome variables and associated factors in different nationalities living in Kuwait

The Mother-Infant Nexus in Anthropology

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