Respiration-coupled rhythms in prefrontal cortex: beyond if, to when, how, and why

Kocsis, Bernát; Pittman-Polletta, Benjamin; Roy, Alexis T.

doi:10.1007/s00429-017-1587-8

Cited by 25 publications

(22 citation statements)

References 28 publications

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“…However, the blockade of NMDARs in nucleus reuniens of the thalamus, an important node mediating interactions between PFC and hippocampus 24 , 62 , also leads to altered prefrontal-hippocampal balance as well as to overexpression of δ rhythms in thalamus and limbic structures 63 – 67 . Additionally, the relationship between the narrowband δ described here and previously 24 and the respiratory rhythm 47 – 51 , 68 is an important question for further investigation.…”

Section: Discussionmentioning

confidence: 68%

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction

Pittman-Polletta

Kocsis

2018

Sci Rep

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NMDAR antagonism alters mesolimbic, hippocampal, and cortical function, acutely reproducing the positive, cognitive, and negative symptoms of schizophrenia. These physiological and behavioral effects may depend differentially on NMDAR subtype- and region-specific effects. The dramatic electrophysiological signatures of NMDAR blockade in rodents include potentiated high frequency oscillations (HFOs, ∼140 Hz), likely generated in mesolimbic structures, and increased HFO phase-amplitude coupling (PAC), a phenomenon related to goal-directed behavior and dopaminergic tone. This study examined the impact of subtype-specific NMDAR antagonism on HFOs and PAC. We found that positive-symptom-associated NR2A-preferring antagonism (NVP-AAM077), but not NR2B-specific antagonism (Ro25-6985) or saline control, replicated increases in HFO power seen with nonspecific antagonism (MK-801). However, PAC following NR2A-preferring antagonism was distinct from all other conditions. While θ-HFO PAC was prominent or potentiated in other conditions, NVP-AAM077 increased δ-HFO PAC and decreased θ-HFO PAC. Furthermore, active wake epochs exhibiting narrowband frontal δ oscillations, and not broadband sleep-associated δ, selectively exhibited δ-HFO coupling, while paradoxical sleep epochs having a high CA1 θ to frontal δ ratio selectively exhibited θ-HFO coupling. Our results suggest: (1) NR2A-preferring antagonism induces oscillopathies reflecting frontal hyperfunction and hippocampal hypofunction; and (2) HFO PAC indexes cortical vs. hippocampal control of mesolimbic circuits.

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Section: Discussionmentioning

confidence: 68%

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction

Pittman-Polletta

Kocsis

2018

Sci Rep

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“…6 ). Further studies that manipulate specific pathways in different behavioral contexts are required to distinguish these possibilities and establish the functional significance of respiration-related neural rhythms 41 .…”

Section: Discussionmentioning

confidence: 99%

Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior

et al. 2018

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Respiration and airflow through the nasal cavity are known to be correlated with rhythmic neural activity in the central nervous system. Here we show in rodents that during conditioned fear-induced freezing behavior, mice breathe at a steady rate (~4 Hz), which is correlated with a predominant 4-Hz oscillation in the prelimbic prefrontal cortex (plPFC), a structure critical for expression of conditioned fear behaviors. We demonstrate anatomical and functional connections between the olfactory pathway and plPFC via circuit tracing and optogenetics. Disruption of olfactory inputs significantly reduces the 4-Hz oscillation in the plPFC, but leads to prolonged freezing periods. Our results indicate that olfactory inputs can modulate rhythmic activity in plPFC and freezing behavior.

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“…For instance, we suspect that the 4-Hz oscillations described to link the mPFC, the ventral tegmental area, and the hippocampus during an odor-based working memory task in rats [28] may correspond to respiration-entrained oscillations. The origin of 2-5-Hz oscillations in the mPFC of anesthetized rats has also recently been suggested to be due to respiration [29][30][31][32]. Interestingly, a recent work showed oscillations of similar frequency in the mPFC and nucleus accumbens of prairie voles during social interactions [33], whose origin has not been determined.…”

Section: Respiration-coupled Activity As a Potential Confound In Deltmentioning

confidence: 99%

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

Tort

Brankačk

Draguhn

2018

Trends in Neurosciences

267

284

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We revisit recent evidence showing that nasal respiration entrains oscillations at the same frequency as breathing in several regions of the rodent brain. Moreover, respiration modulates the amplitude of a specific gamma sub-band (70-120Hz), most prominently in frontal regions. Since rodents often breathe at delta and theta frequencies, we caution that previous studies on delta and theta power and their cross-regional synchrony, as well as on delta-gamma and theta-gamma coupling, may have detected the respiration-entrained rhythm and respiration-gamma coupling. We argue that the simultaneous tracking of respiration along with electrophysiological recordings is necessary to properly identify brain oscillations. We hypothesize that respiration-entrained oscillations aid long-range communication in the brain.

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Respiration-coupled rhythms in prefrontal cortex: beyond if, to when, how, and why

Cited by 25 publications

References 28 publications

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction

Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction

Olfactory inputs modulate respiration-related rhythmic activity in the prefrontal cortex and freezing behavior

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

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