Respiratory adaptation and surfactant composition of unanesthetized male and female lambs differ for up to 8 h after preterm birth

Matteo, Robert De; Ishak, Noreen; Hanita, Takushi; Harding, Richard; Sozo, Foula

doi:10.1038/pr.2015.175

Cited by 20 publications

(30 citation statements)

References 31 publications

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“…; De Matteo et al . ). Indeed, we have previously shown that preterm‐born adult sheep, when challenged, have an increased blood pressure response compared to term‐born sheep, with the males (but not females) exhibiting a dampened baroreflex response (Allison et al .…”

Section: Introductionmentioning

confidence: 97%

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Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep

Mrocki

Nguyen

Lombardo

et al. 2018

The Journal of Physiology

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Preterm birth prematurely exposes the immature heart to the haemodynamic transition at birth, which has the potential to induce abnormal cardiac remodelling. Magnetic resonance imaging studies in young adults born preterm have shown abnormalities in the gross structure of the ventricles (particularly the right ventricle; RV), but the cellular basis of these alterations is unknown. The aim of this study, conducted in sheep, was to determine the effect of moderate preterm birth on RV cellular structure and function in early adulthood. Male singleton lambs were delivered moderately preterm (132 ± 1 days; n = 7) or at term (147 ± 1 days; n = 7). At 14.5 months of age, intra-arterial blood pressure and heart rate were measured. Pulmonary artery diameter and peak systolic blood flow were determined using ultrasound imaging, and RV stroke volume and output calculated. Cardiomyocyte number, size, nuclearity and levels of cardiac fibrosis were subsequently assessed in perfusion-fixed hearts using image analysis and stereological methods. Blood pressure (systolic, diastolic and mean), heart rate, levels of myocardial fibrosis and RV stroke volume and output were not different between groups. There was, however, a significant reduction in RV wall thickness in preterm sheep, and this was accompanied by a significant reduction in peak systolic blood flow in the pulmonary artery and in RV cardiomyocyte number. Cellular changes in the RV wall and reduced pulmonary artery blood flow following preterm birth have the potential to adversely affect cardiac and respiratory haemodynamics, especially when the cardiovascular system is physiologically or pathologically challenged.

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Section: Introductionmentioning

confidence: 97%

“…; De Matteo et al . ), or for the changing demands required of the right ventricle (RV) and left ventricle (LV) (Hooper et al . ; Bensley et al .…”

Section: Introductionmentioning

confidence: 99%

Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep

Mrocki

Nguyen

Lombardo

et al. 2018

The Journal of Physiology

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“…Compared with these previous studies, our study was Articles | Sozo et al performed on gastric aspirate samples collected from infants soon after birth (rather than samples collected during pregnancy) and who were born at earlier gestational ages. Interestingly, in the bronchoalveolar lavage fluid of male lambs collected at 4 h after preterm birth there was a lower PC/PE ratio (equivalent to the PC/S ratio) than in females (19); however, there was no sex difference in the PC/S ratio in amniotic fluid (19) or in lung liquid (25) prior to preterm birth or in bronchoalveolar lavage fluid collected at 8 h after preterm birth in lambs managed on CPAP (26). In addition, no sex difference in the composition of surfactant is observed in very immature or mature rabbit fetuses (18), or in rhesus monkeys in the last trimester-equivalent (27), suggesting that the timing of sample collection, the species, and potentially the sample source influence the data.…”

Section: Sex Differences In the Pc/s Maturity Ratiomentioning

confidence: 91%

“…In contrast, no sex difference in disaturated PC is observed in non-human primates in the last-trimester equivalent (27) or in fetal rabbits at an age that equates tõ 28 weeks of human gestation (28). Similarly, there are no sex differences in PC composition in near-term mice (24), in sheep fetuses (19,25), or in preterm lambs that are spontaneously breathing and managed on CPAP (26) or anesthetized and ventilated (29). Conversely, spontaneously breathing male preterm lambs not managed on CPAP have lower proportions of DPPC and PC than do females (19).…”

Section: Sex Differences In the Composition Of Pcmentioning

confidence: 95%

Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants

et al. 2017

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BackgroundAmong preterm infants, males have a greater incidence of respiratory distress and death than do females born at the same gestational age, likely due to sex-related differences in lung maturation. Our aim was to determine whether surfactant phospholipid composition differs between male and female preterm infants.MethodsGastric aspirate samples from male and female infants born between 25 and 30 weeks of gestation at The Royal Women's Hospital, Melbourne, Australia, were collected within 1 h after birth. Phospholipid composition was analyzed by electrospray ionization tandem mass spectrometry.ResultsPreterm males had higher proportions of total phosphatidylinositol (PI) and phosphatidylserine 36:2, lower proportions of total sphingomyelin (S) and S 33:1 and 35:1, and a greater phosphatidylcholine (PC)/S ratio than did females. The proportions of PC 30:0, PC 34:0, PC 34:2, PC 36:2, PC 36:3, and PC 38:2 differed between the sexes at different gestational weeks of birth; the proportion of PC 32:0 (dipalmitoylphosphatidylcholine) in males was lower than that in females at 25 weeks of gestation but higher at 27 weeks.ConclusionPhospholipid composition in pulmonary surfactant is different between male and female preterm infants of the same gestational age, which may contribute to the increased risk for respiratory morbidities in one sex.

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“…The finding is in agreement with previous literature, and is often attributed to the higher susceptibility of male preterm infants to the respiratory distress syndrome problem [38] . This gender difference has been reduced by the use of continuous positive airway pressure [39] . Therefore, the issue may need further study with a suitable sample size.…”

Section: Physiological Adaptation Among Preterm Infants and Associatementioning

confidence: 99%

Physiological Adaptation among Preterm Infants and Associated Maternal Factors

Attia¹,

Elsharkawy²

2016

IOSR JNHS

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Respiratory adaptation and surfactant composition of unanesthetized male and female lambs differ for up to 8 h after preterm birth

Cited by 20 publications

References 31 publications

Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep

Moderate preterm birth affects right ventricular structure and function and pulmonary artery blood flow in adult sheep

Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants

Physiological Adaptation among Preterm Infants and Associated Maternal Factors

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