Respiratory and cardiovascular effects of COVID-19 infection and their management

Kapoor, Mukul Chandra

doi:10.4103/joacp.joacp_242_20

Cited by 10 publications

(12 citation statements)

References 46 publications

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“…Although COVID-19 primarily manifests as a respiratory pathogen causing pneumonia and respiratory failure [2][3][4], much remains unknown about this relatively new pathogen and its involvement of other organ systems. Abnormalities of the enteric tract have been reported in previously published radiologic series [5,6], and SARS-CoV-2 RNA has been isolated in the duodenal wall and feces of some patients [7].…”

Section: Introductionmentioning

confidence: 99%

Abdominal imaging findings on computed tomography in patients acutely infected with SARS-CoV-2: what are the findings?

et al. 2021

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Objectives To investigate what findings are new on contrast-enhanced abdominopelvic CT in patients infected with SARS-CoV-2. Methods Contrast-enhanced CT of the abdomen and pelvis of patients with COVID-19 at a tertiary oncologic center acquired over a 2-month period were reviewed independently by two readers and scored for new imaging abnormalities compared with a prior scan. CT scans were included if the study was performed between − 3 and 45 days from the time of COVID-19 diagnosis. Clinical information was gathered from the medical records. Results A total of 63 patients (34 male, 29 female; mean age 60.6 years, range 24.4–85.0 years) were included in this retrospective cross-sectional study. Aside from new ground glass opacities seen at the lung bases (29/63, 46.0%), the most common findings were new thickening of the stomach, small bowel or colon or fluid-filled colon (14/63, 22.2%), new small volume ascites (7/63, 14.3%), gallbladder distention in those without prior cholecystectomy (3/43, 7.0%), and single cases each of acute pancreatitis (1/63, 1.6%) as well as new portal vein thrombosis (1/63, 1.6%). Conclusion Aside from lung base ground glass opacities, the most common new imaging abnormality on abdominopelvic CT in patients with COVID-19 finding in our cohort was abnormalities of the gastrointestinal tract, followed by small volume ascites, gallbladder distention, and isolated cases of pancreatitis and portal vein thrombosis. These findings overlap with those previously reported that did not have a prior scan for comparison, and provide supportive evidence that some of these findings may be related to SARS-CoV-2 infection.

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Section: Introductionmentioning

confidence: 99%

Abdominal imaging findings on computed tomography in patients acutely infected with SARS-CoV-2: what are the findings?

et al. 2021

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“…Analysis of mutations in the coding and non-coding regions, genetic diversity, and pathogenicity of SARS-CoV-2 has also been carried out and based on the results it was suggested that a minimal variation in the genome sequence of SARS-CoV-2 may be responsible for a drastic change in the structures of target proteins, making available drugs ineffective ( Naqvi et al, 2020 ). Clinical data show that the main structures of the body that are affected by COVID-19 are the respiratory and cardiovascular systems ( Kapoor, 2020 ; Lazzeri et al, 2020 ; Yi et al, 2021 ). However, SARS-CoV-2 is able to infect other systems, such as the digestive, urogenital and nervous systems ( Zhang Y. et al, 2020 ; Spudich and Nath, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease

et al. 2022

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Evidence suggests that SARS-CoV-2 entry into the central nervous system can result in neurological and/or neurodegenerative diseases. In this review, routes of SARS-Cov-2 entry into the brain via neuroinvasive pathways such as transcribrial, ocular surface or hematogenous system are discussed. It is argued that SARS-Cov-2-induced cytokine storm, neuroinflammation and oxidative stress increase the risk of developing neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Further studies on the effects of SARS-CoV-2 and its variants on protein aggregation, glia or microglia activation, and blood-brain barrier are warranted.

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“…After infecting a person's respiratory system, COVID-19 can progress to cause systemic illness. The virus causes multi-organ dysfunction and failure, with the lungs being the most afflicted and the cardiovascular system following it closely (2) . SARS-CoV-2, the virus that causes COVID-19, mostly affects the respiratory system, however people who have a history of cardiovascular illness or have high cardiac biomarkers are more vulnerable and have a worse prognosis (3) .…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Manifestations in Echocardiography in Patients Recently Recovered From COVID-19 Infection

Bensaeed¹,

El-Sherbiny²,

Shereef³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: As a major source of morbidity and mortality, COVID-19 (coronavirus disease 2019) has developed. In both COVID-19 and other pneumonias, high T/I troponin levels may indicate damage to the heart. Objective: ln order to expand our understanding of COVID-19 cardiology effects, as well as provide insights into the features of people who are more prone to cardiovascular diseases. Methods: At isolation hospital in Zagazig, and the isolation hospital in Tripoli, Libya, 42 COVID-19 positive subjects were studied for their echocardiographic parameters, the study was carried out from March 5 th , 2021, to September 4 th 2021. Results: Arrhythmias, myocardial infarctions, valvular dysfunction, pulmonary hypertension, and right ventricular dysfunction (RVD) were found to have no statistically significant association to the severity of COVID-19. Mean of left ventricular ejection fraction (LVEF) was statistically lower among severe COVID-19 patients than moderate and mild cases but means of RV diameter (mm) was statistically higher among severe COVID-19 patients than moderate and mild cases, mean of fractional area change (FAC) was statistically lower in severe COVID-19 patients. Pulmonary hypertension was the second most common echocardiographic finding (38% of patients). There was no statistically significant difference in pulmonary hypertension across COVID-19 patients in relation to the severity (P=0.211). Conclusion:Echocardiography can provide us with important information which can help in managing of patients with COVID-19 while we must consider contamination risks as well as transmission of diseases.

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Respiratory and cardiovascular effects of COVID-19 infection and their management

Cited by 10 publications

References 46 publications

Abdominal imaging findings on computed tomography in patients acutely infected with SARS-CoV-2: what are the findings?

Abdominal imaging findings on computed tomography in patients acutely infected with SARS-CoV-2: what are the findings?

Neuropathological Aspects of SARS-CoV-2 Infection: Significance for Both Alzheimer’s and Parkinson’s Disease

Cardiovascular Manifestations in Echocardiography in Patients Recently Recovered From COVID-19 Infection

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