Respiratory and circulatory effects of pentazocine. Review of analgesics used after myocardial infarction.

Abstract

and the Royal Infirmary, SheffieldThe analgesic pentazocine has been studied in myocardial infarction. A dose of 30 mg given intravenously provokes significant respiratory depression (which may be potentiated by lignocaine). This dose caused a small, but not significant rise in systemic arterial pressure and heart rate when breathing air. Attempts to provoke postural hypotension failed. Changes in pulmonary arterial pressure and arteriovenous oxygen difference were small and not significant.The published reports have been reviewed with a view to determining the most suitable intravenous analgesic for use after myocardial infarction. Pethidine and morphine appear to be unsatisfactory. Pentazocine is preferable to either, but less satisfactory than heroin in a normotensive patient. Dosage should be as small as practicable and injection slow. Oxygen should be given routinely; phenothiazines should not.

Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes

“…Many reports suggested that pentazocine shows cardioprotective effects in human in the early phase after cardiac surgery or isolated ischemic heart (3,21,27,33). However, it is unclear whether chronic pentazocine treatment inhibits heart failure following PO-induced hypertrophy.…”

“…The ameliorated effect of pentazocine after cardiac ischemia is reported in the Langendorff-perfused isolated heart preparation (27). Moreover, pentazocine shows cardioprotective effects in human or rodents after cardiac surgery (3,14,21,33). Although the previous studies suggested that pentazocine regulates Ca 2ϩ mobilization from sarcoplasmic reticulum (SR)/endoplasmic reticulum (ER) through opioid or -1 receptors ( 1 R) (8, 23), the precise cardioprotective mechanisms of pentazocine in cardiomyocytes remain unclear.…”

Opioids: 3.4 Opioids with Clinical Relevance

“…In high doses seizures may occur (Challoner et al, 1990). Respiratory depression is weaker than with morphine and is subject to a 'ceiling' effect (Nagle and Pilcher, 1972). Respiratory depression is weaker than with morphine and is subject to a 'ceiling' effect (Nagle and Pilcher, 1972).…”

Effect of Epidural Ketamine in Combination with Opioids on Haemodyanamics and Electrocardiograph in Dogs

“…Mean arterial pressure showed a slight increase in women after epidural administration of meperidine (Khaw et al, 2000). Pethidine and pentazocine increase the heart rate and systemic arterial pressure after its use in myocardial infarction in man (Lee et al, 1976;Nagle and Pilcher, 1972). This increase in systemic arterial pressure was assumed to be caused by peripheral resistance.…”