Respiratory and metabolic effects of oral nefopam in human volunteers.

Bhatt, AM; Pleuvry, Barbara J.; Maddison, S E

doi:10.1111/j.1365-2125.1981.tb01126.x

Cited by 29 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrary to opioid analgesics, Nefopam does not produce addiction or respiratory depression, somnolence, urinary retention or ileus. It has no action on platelet function, being used in patients with hemorrhagic diathesis, unlike nonsteroidal anti-inflammatory agents [8]. A meta-analysis made by Evans et al in 2008 had shown that the use of Nefopam in postoperative period lead to lowering of the opioid drug dose with almost 30% in the first 24 h after surgery (postoperative morphine-sparing) [15].…”

Section: The Role Of Nefopam In Multimodal Analgesiamentioning

confidence: 99%

“…To avoid the appearance of these adverse effects, the manufacturer recommended that the drug should be slowly injected. But it does not cause tolerance or physical dependence, has no hemodynamic effects, does not induce respiratory depression and has no sedative effect with a safety profile regarding coagulopathy (no effect on platelet function) [8]. All of this should be put in balance with the side effects of the other pharmacologic classes of analgesics in pain management.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Nefopam and its Role in Modulating Acute and Chronic Pain

Ţigliş¹,

Neagu²,

Elfara³

et al. 2018

Rev. Chim.

View full text Add to dashboard Cite

Pain is a very important issue to take into account during hospitalization. Nefopam, a centrally acting analgesic, has a relative safety pharmacological profile with few and well-tolerated side effects, being used to treat acute or chronic pain. It inhibits the central reuptake of serotonin, norepinephrine and dopamine and modulates the sodium and calcium channels having only few contraindications. Nefopam can be part of balanced analgesia along with others non-opioids agents in order to reduce the opioid consumption and their complications, to control postoperative pain and to reduce the risk of neuropathic pain appearance. In order to avoid its adverse reactions, a slow infusion is always recommended. Nefopam has its role in preventing the shivering appearance during neuraxial or general anesthesia, can modulate the emergence agitation after nasal and maxillofacial surgery and can inhibit the sever hiccup during mechanical ventilation. Some cases about fatal overdoses are reported in the literature.

show abstract

Section: The Role Of Nefopam In Multimodal Analgesiamentioning

confidence: 99%

mentioning

confidence: 99%

Nefopam and its Role in Modulating Acute and Chronic Pain

Ţigliş¹,

Neagu²,

Elfara³

et al. 2018

Rev. Chim.

View full text Add to dashboard Cite

show abstract

“…24 Nefopam does not have sedative and hemodynamic effects as do ␣ 2 agonists, nor does it cause respiratory depression as do opioids. 25 This article is accompanied by an Editorial View. Talke P: It's hot to be cool.…”

mentioning

confidence: 99%

Nefopam and Alfentanil Additively Reduce the Shivering Threshold in Humans whereas Nefopam and Clonidine Do Not

et al. 2009

View full text Add to dashboard Cite

show abstract

“…As a result, it is effective in the prevention and treatment of shivering. Unlike other drugs [89], nefopam maintains hemodynamic stability [1011], but does not induce respiratory depression or sedation.…”

Section: Introductionmentioning

confidence: 99%

Comparison of effect of electroacupuncture and nefopam for prevention of postanesthetic shivering in patients undergoing urologic operation under spinal anesthesia

Hong

Kim

Hwang

2016

Korean J Anesthesiol

View full text Add to dashboard Cite

BackgroundShivering during spinal anesthesia is a frequent complication and is induced by the core-to-peripheral redistribution of heat. Nefopam has minimal side effects and prevents shivering by reducing the shivering threshold. Electroacupuncture is known to prevent shivering by preserving the core body temperature. We compared the efficacies of electroacupuncture and nefopam for the prevention of shivering during spinal anesthesia.MethodsNinety patients scheduled for elective urological surgery under spinal anesthesia were enrolled in the study. Patients were randomly divided into the control group (Group C, n = 30), the electroacupuncture group (Group A, n = 30), and the nefopam group (Group N, n = 30). Groups C and A received 100 ml of isotonic saline intravenously for 30 minutes before spinal anesthesia, while Group N received nefopam (0.15 mg/kg) mixed in 100 ml of isotonic saline. Group A received 30 minutes of electroacupuncture before receiving anesthesia. Shivering scores, mean arterial pressure, heart rate, body temperature and side effects were recorded before, and at 5, 15, 30, and 60 minutes after spinal anesthesia.ResultsThe incidence of postanesthetic shivering was significantly lower in Group N (10 of 30) and Group A (4 of 30) compared with that in Group C (18 of 30)(P < 0.017). Body temperature was higher in Group N and Group A than in Group C (P < 0.05). Hemodynamic parameters were not different among the groups.ConclusionsBy maintaining body temperature during spinal anesthesia, electroacupuncture is as effective as nefopam in preventing postanesthetic shivering.

show abstract

Respiratory and metabolic effects of oral nefopam in human volunteers.

Cited by 29 publications

References 10 publications

Nefopam and its Role in Modulating Acute and Chronic Pain

Nefopam and its Role in Modulating Acute and Chronic Pain

Nefopam and Alfentanil Additively Reduce the Shivering Threshold in Humans whereas Nefopam and Clonidine Do Not

Comparison of effect of electroacupuncture and nefopam for prevention of postanesthetic shivering in patients undergoing urologic operation under spinal anesthesia

Contact Info

Product

Resources

About