Respiratory care for the critical patients with 2019 novel coronavirus

Wang, Yao-Chen; Lu, Min-Chi; Yang, Shun-Fa; Bien, Mauo-Ying; Chen, Yifang; Li, Yia-Ting

doi:10.1016/j.rmed.2021.106516

Cited by 21 publications

(20 citation statements)

References 160 publications

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“…We observed greater performance of respiratory function in male and female groups with HEPA filters than in those groups without HEPA filters during the air pollution period and after a long-term period (e.g., 6-months), supporting that HEPA could alleviate the respiratory risks due to the exposures to air pollution [28,29]. These observed findings were also supported by the results of biological indicators.…”

Section: Discussionsupporting

confidence: 81%

The Effects of Indoor Air Filter on Reductions in PM2.5 Associated Health Risks of Respiratory Function in Mouse

Yang

Liu

et al. 2022

Atmosphere

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This study aimed to assess whether protective measures could reduce the health risks of air pollution in mice living in the chambers situated at a suburban site in Beijing. The living chambers of mice were divided into four groups: male mice with and without the high-efficiency particulate air (HEPA) filter (male group A and group B), as well as female mice with and without the HEPA filter (female group A and group B). The experiment was carried out from 1 December 2017 to 31 May 2018. Parameters of respiratory function during periods of clean air and air pollution were determined for all groups to evaluate the role of the indoor air filter (i.e., HEPA) in protection against respiratory health risks in mice. Significant differences in minute volumes were observed in male and female groups with versus without the HEPA. Additionally, respiratory health parameters including respiratory rate, duration of breaking, expiratory time, and relaxation time exhibited differences in female groups with HEPA versus without HEPA. Levels of inflammatory factors in the lungs were measured for all groups after 6months of exposure. Greater mean levels of IL-6 and TNF-α were found in the male groups without HEPA than in those with HEPA. Higher average concentrations of IL-6, T-AOC, SOD, GSH-Px, LDH, TNF-α, and TGF-β1 were found in the female group without HEPA than those without HEPA. Our study has proved the effective protection provided by indoor air filters (i.e., HEPA filters) in reducing respiratory health risks associated with PM2.5.

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Section: Discussionsupporting

confidence: 81%

The Effects of Indoor Air Filter on Reductions in PM2.5 Associated Health Risks of Respiratory Function in Mouse

Yang

Liu

et al. 2022

Atmosphere

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“…Hypoxemia requiring oxygen therapy was defined as an SpO2 of ≤93% at rest/motion under room air. This is a universally accepted criterion for the initiation of oxygen therapy in patients with COVID-19 ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

Circulating Type I Interferon Levels in the Early Phase of COVID-19 Are Associated With the Development of Respiratory Failure

et al. 2022

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BackgroundThe role of type I interferons (IFNs) in the early phase of COVID-19 remains unclear.ObjectivesTo evaluate the relationship between IFN-I levels in patients with COVID-19 and clinical presentation, SARS-CoV-2 viral load, and other major pro-inflammatory cytokines.MethodsThis prospective observational study recruited patients hospitalized with COVID-19. The levels of interferon-alpha (IFN-α), interferon-beta (IFN-β), interleukin-6 (IL-6), and C-X-C motif chemokine ligand (CXCL10) within 5 days after symptom onset were measured using an ELISA, in serum from blood collected within 5 days after the onset of symptoms. The SARS-CoV-2 viral load was determined via qPCR using nasal-swab specimens and serum.ResultsThe study enrolled 50 patients with COVID-19. IFN-α levels were significantly higher in patients who presented with pneumonia or developed hypoxemic respiratory failure (p < 0.001). Furthermore, IFN-α levels were associated with viral load in nasal-swab specimens and RNAemia (p < 0.05). In contrast, there was no significant association between IFN-β levels and the presence of pneumonia or RNAemia, despite showing a stronger association with nasal-swab viral load (p < 0.001). Correlation analysis showed that the serum levels of IFN-α significantly correlated with those of IFN-β, IL-6, and CXCL10, while the levels of IFN-β did not correlate with those of IL-6 or CXCL10.ConclusionsSerum IFN-I levels in the early phase of SARS-CoV-2 infection were higher in patients who developed hypoxemic respiratory failure. The association between IFN-α, IL-6, and CXCL10 may reflect the systemic immune response against SARS-CoV-2 invasion into pulmonary circulation, which might be an early predictor of respiratory failure due to COVID-19.

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“…In 2019 the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged and evolved to a pandemic that challenges health care professionals worldwide. The clinical symptoms of coronavirus disease 2019 (COVID-19) vary from asymptomatic patients via fever and cough through to severe pneumonia and life-threatening acute respiratory distress syndrome (ARDS) [ 1 , 2 , 3 ]. Up to one-fourth of all hospitalized patients suffering from COVID-19 can be classified as critically ill, requiring intensive care treatment including invasive mechanical ventilation or vasopressor-therapy [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis

Jäckel

Aicher

Biever

et al. 2021

JCM

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Background: Delirium complicating the course of Intensive care unit (ICU) therapy is a known driver of morbidity and mortality. It has been speculated that infection with the neurotrophic SARS-CoV-2 might promote delirium. Methods: Retrospective registry analysis including all patients treated at least 48 h on a medical intensive care unit. The primary endpoint was development of delirium as diagnosed by Nursing Delirium screening scale ≥2. Results were confirmed by propensity score matching. Results: 542 patients were included. The primary endpoint was reached in 352/542 (64.9%) patients, without significant differences between COVID-19 patients and non-COVID-19 patients (51.4% and 65.9%, respectively, p = 0.07) and correlated with prolonged ICU stay in both groups. In a subgroup of patients with ICU stay >10 days delirium was significantly lower in COVID-19 patients (p ≤ 0.01). After adjustment for confounders, COVID-19 correlated independently with less ICU delirium (p ≤ 0.01). In the propensity score matched cohort, patients with COVID-19 had significantly lower delirium incidence compared to the matched control patients (p ≤ 0.01). Conclusion: Delirium is frequent in critically ill patients with and without COVID-19 treated at an intensive care unit. Data suggests that COVID-19 itself is not a driver of delirium per se.

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Respiratory care for the critical patients with 2019 novel coronavirus

Cited by 21 publications

References 160 publications

The Effects of Indoor Air Filter on Reductions in PM2.5 Associated Health Risks of Respiratory Function in Mouse

The Effects of Indoor Air Filter on Reductions in PM2.5 Associated Health Risks of Respiratory Function in Mouse

Circulating Type I Interferon Levels in the Early Phase of COVID-19 Are Associated With the Development of Respiratory Failure

Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis

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