Respiratory Complications in Children Hospitalized with Respiratory Syncytial Virus Infection

Wrotek, August; Kobiałka, Małgorzata; Grochowski, Bartłomiej; Kaminska, I; Pędziwiatr, Kaja; Skoczek-Wojciechowska, Anna; Godek, Maria; Jackowska, Teresa

doi:10.1007/5584_2020_530

Cited by 13 publications

(18 citation statements)

References 27 publications

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“…Children up to two years of age frequently experience a severe course of RSV infection other than the most common manifestation, bronchiolitis. Its occurrence among hospitalized patients ranges from 56% to 79%, which is consistent with our results (66.15%) (22)(23)(24). Differences appear, however, in the percentages of particular manifestations.…”

Section: Discussionsupporting

confidence: 92%

“…Both acute otitis media (n = 4; 3.08%) and conjunctivitis (n = 4; 3.08%) were surprisingly rare manifestations in our study group with RSV infection. According to the data in the literature, AOM affects 24% to even 58% of patients (22)(23)(24)(25)(26). However, these are mainly prospective studies, with the observation period up to one year after the end of hospitalization, which may lead to a higher percentage of this manifestation than in our retrospective study.…”

Section: Discussionmentioning

confidence: 59%

“…However, these are mainly prospective studies, with the observation period up to one year after the end of hospitalization, which may lead to a higher percentage of this manifestation than in our retrospective study. Moreover, in the above-mentioned studies, only Wrotek et al (22) de- scribed conjunctivitis as a complication, which affected 11% of their study group. Whereas in the study conducted by Souty et al (27), regarding the occurrence of influenzalike viral infection symptoms, no statistically significant association was proved between the RS virus and conjunctivitis.…”

Section: Discussionmentioning

confidence: 98%

“…In our study, the most common one was pneumonia (n = 82; 63.08%), reaching a much higher percentage than in previous studies. Wrotek et al (22) reported that pneumonia occurred in 33% of patients under 22 months of age. Hall et al (3) showed that this condition was developed in 51% of children aged 24 -59 months, whereas according to Heikkinen et al (24), only 3% of patients up to 13 years of age had such a manifestation (24).…”

Section: Discussionmentioning

confidence: 99%

“…Yet, there are fewer studies that would define the risk groups for severe course of the infection on hospitalized children, which is the main subject of this study. Wrotek et al (22) suggested that only the age above three months predisposed to AOM and pneumonia in the course of RSV infection. In our study, however, pneumonia was observed mainly in children younger than six months of age.…”

Section: Discussionmentioning

confidence: 99%

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Manifestations and Risk Factors in Children Hospitalized with Respiratory Syncytial Virus Infection

Kuczborska

Rustecka

Wawrzyniak

et al. 2020

Arch Pediatr Infect Dis

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Background: Acute lower respiratory infection (ALRI) is one of the main causes of morbidity and mortality in children under five years of age, and the respiratory syncytial virus (RSV) remains its leading etiological factor. Although RSV infections occur in all age groups, the most severe course is observed among children. The clinical manifestations include both mild upper respiratory infections and severe infections of the lower tract, such as bronchiolitis and pneumonia that can lead to hospitalization and severe complications, including respiratory failure. Objectives: The study aimed to evaluate the manifestations of RSV infection in hospitalized children younger than 18 months of age and predictors of disease severity, as well as their comparison with the same age group hospitalized due to ALRI of different etiology. Methods: A retrospective analysis was performed on medical records of 448 children hospitalized due to ALRI. The analysis was performed on the total study group and subgroups of children with positive and negative results of the nasal swab for RSV detection. In each group, clinical data, laboratory test results, and imaging results were analyzed. Results: The most common manifestation was pneumonia (n = 82; 63.08%). Otitis media was observed mainly in children under six months of age with lowered inflammatory markers (P < 0.05), conjunctivitis in those with a positive family history of allergies (P < 0.05), and pneumonia in children under six months of age, with lower blood oxygen saturation and inflammatory markers, features of acidosis, and fever-free course (P < 0.05). Respiratory failure affected 13 children (10%). However, no predictors of this complication were noted. Conclusions: As pneumonia was the most common manifestation in children with both RSV-positive and RSV-negative ALRI, it seems advisable to perform the imaging of the lungs on admission and carefully monitor the child’s condition during hospitalization. In both groups, special attention should be paid to the youngest children with low inflammatory markers on hospital admission, increased clinical symptoms, and family history of allergies. Nevertheless, widely known risk factors of RSV infection itself do not reflect the risk of developing pneumonia or respiratory failure in its course.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Manifestations and Risk Factors in Children Hospitalized with Respiratory Syncytial Virus Infection

Kuczborska

Rustecka

Wawrzyniak

et al. 2020

Arch Pediatr Infect Dis

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Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China

Wang

et al. 2020

JAMA Ophthalmol

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IMPORTANCE Ocular manifestations and outcomes in children with confirmed coronavirus disease 2019 , relevant affecting factors, and differences in ocular disease between children and adults have yet to be fully understood. OBJECTIVE To investigate ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19. DESIGN, SETTING, AND PARTICIPANTS This cross-sectional study was conducted at Wuhan Children's Hospital in Wuhan, China. Children with COVID-19 confirmed by severe acute respiratory syndrome coronavirus disease 2 nucleic acid tests of upper respiratory tract specimens between January 26 and March 18, 2020, were included. MAIN OUTCOMES AND MEASURES Onset clinical symptoms and duration, ocular symptoms, and needs for medication. RESULTS A total of 216 pediatric patients were included, among whom 134 (62%) were boys, with a median (interquartile range) age of 7.25 (2.6-11.6) years. Based on the exposure history, 193 children (89.4%) had a confirmed (173 [80.1%]) or suspected (20 [9.3%]) family member with COVID-19 infection. The most common symptoms among symptomatic children were fever (81 [37.5%]) and cough (79 [36.6%]). Of 216 children, 93 (43.1%) had no systemic or respiratory symptoms. All children with mild (101 [46.8%]) or moderate (115 [53.2%]) symptoms recovered without reported death. Forty-nine children (22.7%) showed various ocular manifestations, of which 9 had ocular complaints being the initial manifestations of COVID-19. The common ocular manifestations were conjunctival discharge (27 [55.1%]), eye rubbing (19 [38.8%]), and conjunctival congestion (5 [10.2%]). Children with systemic symptoms (29.3% vs 14.0%; difference, 15.3%; 95% CI, 9.8%-20.7%; P = .008) or with cough (31.6% vs 17.5%; difference, 14.1%; 95% CI, 8.0%-20.3%; P = .02) were more likely to develop ocular symptoms. Ocular symptoms were typically mild, and children recovered or improved. CONCLUSIONS AND RELEVANCEIn this cross-sectional study, children hospitalized with COVID-19 in Wuhan, China, presented with a series of onset symptoms including fever, cough, and ocular manifestations, such as conjunctival discharge, eye rubbing, and conjunctival congestion. Patients' systemic clinical symptoms or cough were associated with ocular symptoms. Ocular symptoms recovered or improved eventually.

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ISOM 2023 research Panel 4 - Diagnostics and microbiology of otitis media

Tamir,

Bialasiewicz,

Brennan-Jones

et al. 2023

International Journal of Pediatric Otorhinolaryngology

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Respiratory Complications in Children Hospitalized with Respiratory Syncytial Virus Infection

Cited by 13 publications

References 27 publications

Manifestations and Risk Factors in Children Hospitalized with Respiratory Syncytial Virus Infection

Manifestations and Risk Factors in Children Hospitalized with Respiratory Syncytial Virus Infection

Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China

ISOM 2023 research Panel 4 - Diagnostics and microbiology of otitis media

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