Abstract:The origin of airway secretion is thought to be in the seromucous glands, goblet cells, transudation from capillary secretions and cell debris from leucocytes. We demonstrated that ciliated airway epithelial cells have chloride channel activities and can secrete chloride ions after administration of isoproterenol, ATP, UTP and acetylcholine using the patch-clamp technique. The activated chloride channel activities were significantly inhibited by macrolide.We concluded that the periciliary layer of low viscosit… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.