Respiratory-Dependent Laser–Doppler Flux Motion in Different Skin Areas and Its Meaning to Autonomic Nervous Control of the Vessels of the Skin

Mück-Weymann, M.; Albrecht, Hans; Hager, David N.; Hiller, D.; Hornstein, O. P.; Bauer, R. D.

doi:10.1006/mvre.1996.0044

Cited by 67 publications

(31 citation statements)

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“…The oscillations of the microvascular blood perfusion signal can be divided into different components by spectral analysis (Meyer et al 1988;Intaglietta 1989;Hoffmann et al 1990;Stefanovska 1992;Bollinger et al 1993;Mu¨ck-Weymann et al 1996). From the LDF curve (Fig.…”

Section: Spectral Analysismentioning

confidence: 99%

Enhanced endothelial activity reflected in cutaneous blood flow oscillations of athletes

Kvernmo¹,

Stefanovska

Kirkebøen³

2003

Eur J Appl Physiol

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Functional alterations of vascular endothelial cells may be evaluated by analysing differences in effects of endothelium-dependent [acetylcholine (ACh)] and endothelium-independent [sodium nitroprusside (SNP)] vasodilators. We evaluated whether a dynamic approach using spectral analysis of the blood flow signal, resulting from the cutaneous red cell flux and recorded by the technique of laser Doppler flowmetry (LDF), can detect higher endothelial responsiveness in trained versus less trained individuals. There was a 1.6 times higher ACh-induced cutaneous perfusion in athletes than in controls ( P<0.05), both when evaluated as a mean value of the LDF signal or as the amplitudes of its spectral components. In the frequency interval from 0.009 to 1.6 Hz, ACh induced a 1.6 times higher average spectral amplitude ( P<0.01) in athletes compared with controls. ACh also induced a 1.6 times higher absolute spectral amplitude of the oscillator at around 0.01 Hz ( P<0.05) in the athletes compared with the controls, whereas the endothelial oscillation at around 0.01 Hz during basal unstimulated perfusion was 1.5 times higher ( P<0.01). There were no significant differences in absolute or relative amplitude during iontophoresis with SNP. These results indicate that athletes have higher endothelial activity than less trained individuals.

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Section: Spectral Analysismentioning

confidence: 99%

Enhanced endothelial activity reflected in cutaneous blood flow oscillations of athletes

Kvernmo¹,

Stefanovska

Kirkebøen³

2003

Eur J Appl Physiol

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“…The oscillations of the microvascular blood perfusion signal can be divided into different components by spectral analysis [18, 19, 20, 21, 23, 43]. Five oscillations with characteristic frequencies seen as peaks in the wavelet transformation were observed within the frequency interval 0.0095–2 Hz.…”

Section: Methodsmentioning

confidence: 99%

“…Spectral analysis is used to reveal characteristic frequencies of the periodic oscillations in microvascular blood flow [17, 18]. With various degree of confidence previous studies show that these frequencies reflect the influence of heartbeat (interval V, 0.6–1.6 Hz), respiration (interval IV, 0.145–0.6 Hz) [19, 20], intrinsic myogenic activity (interval III, 0.052–0.145 Hz) [21, 22, 23, 24], neurogenic factors (interval II, 0.021–0.052 Hz) [22, 25]and endothelial activity (interval I, 0.0095–0.021 Hz) [26, 27, 28]. …”

Section: Introductionmentioning

confidence: 99%

Skin Blood Flow in the Upper and Lower Extremities of Diabetic Patients with and without Autonomic Neuropathy

et al. 2004

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Background: Microvascular blood flow in the human skin is subject to rhythmic variations reflecting the influence of heartbeat, respiration, intrinsic myogenic activity, neurogenic factors and endothelial activity. The aim of our study was to test the hypothesis that basal skin blood flow (BSBF) and its dynamic components differ (1) among diabetic patients without autonomic neuropathy and with it and healthy control subjects, and (2) among the upper and lower extremities. Patients and Methods: BSBF at four recording sites with predominantly nutritive capillary circulation (right and left caput ulnae, right and left medial malleolus) was measured by laser Doppler flowmetry in 25 diabetic patients without cardiovascular autonomic neuropathy (D), 18 neuropathic diabetic patients (DAN) and 36 healthy controls (C). Wavelet transform was applied to the laser Doppler signal. Results: In absolute terms, mean flow, mean amplitude of the total spectrum and mean amplitudes at all frequency intervals were highest in C, followed by DAN and lowest in D. However, these differences were statistically significant only in the left arm. Within all three groups, mean flow and spectral amplitudes were significantly higher in the arms than in the legs, besides there was a significant difference between the two arms in D. Conclusion: We have confirmed the differences in BSBF among D, DAN and C, and demonstrated differences among the four recording sites which have not been previously described. The latter indicates an uneven progression of autonomic neuropathy and allows for speculation that the left arm is the latest to be affected.

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“…18 The pulse (0.8-1.6 Hz) and respiratory (0.2-0.4 Hz) ranges are identi¯ed among the passive mechanisms of regulation, which characterize the in°uence of heart rate and movement of the thorax. [18][19][20] Active mechanisms of regulation are myogenic (0.047-0.145 Hz), transmitting the activity of vascular smooth muscle cells, [21][22][23] neurogenic (0.021-0.046 Hz), showing the in°uence of neurogenic sympathetic vasomotor activity, 21,24 and endothelial (0.0095-0.02 Hz), re°ecting the vasomotor activity of vascular endothelium. [25][26][27] Thus, with the use of this mathematical apparatus, it possible to evaluate the main factors provoking vasoconstriction and angiospastic disorder.…”

Section: Introductionmentioning

confidence: 99%

Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies

Makovik

Dunaev

Dremin

et al. 2017

J. Innov. Opt. Health Sci.

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The evaluation of the microcirculatory bed functional state and the identi¯cation of angiospastic disorders with related complications, when the pathological changes are reversible, have an important role in medical practice. The aim of this study was to evaluate the possibility of using optical noninvasive methods and the cold pressor test to solve this problem. A total of 33 patients with rheumatological diseases and 32 healthy volunteers were included in the study. Laser Doppler°owmetry, tissue re°ectance oximetry and pulse oximetry were used as optical noninvasive methods. The parameters were recorded before, immediately after and 20 min after the cold pressor test. Based on the measured parameters, the complex parameters of the microcirculatory bed were calculated.A detailed statistical analysis of the parameter changes for each individual in the two groups displayed diverse microcirculatory bed parameter responses upon cold exposure, with di®ering recovery of parameters after CPT. New diagnostic criteria were proposed for the identi¯cation of angiospastic disorders. According to the proposed criteria, 27 people of the volunteers group were con¯rmed to not display any disorders. In the patient group, however, 18 people were observed to have a relatively normal functional state of the microcirculatory bed, while 15 people were observed to have a possible tendency to angiospasm. To highlight the di®erences between a relatively normal state and presence of angiospastic disorders, statistical analysis of experimental data was carried out, which revealed signi¯cant di®erences. Further analysis of data with angiospastic disorders identi¯ed a relationship between their diagnoses and the results of laboratory studies.Thus, the evaluation of combined noninvasive optical diagnostic method use, the cold pressor test and proposed diagnostic criteria showed a positive result. This approach can be used to detect the presence of possible angiospastic disorders and related complications, as well as microcirculatory bed disorders against the background of other diseases.

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Respiratory-Dependent Laser–Doppler Flux Motion in Different Skin Areas and Its Meaning to Autonomic Nervous Control of the Vessels of the Skin

Cited by 67 publications

References 0 publications

Enhanced endothelial activity reflected in cutaneous blood flow oscillations of athletes

Enhanced endothelial activity reflected in cutaneous blood flow oscillations of athletes

Skin Blood Flow in the Upper and Lower Extremities of Diabetic Patients with and without Autonomic Neuropathy

Detection of angiospastic disorders in the microcirculatory bed using laser diagnostics technologies

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