Respiratory disease in growing pigs after Porcine rubulavirus experimental infection

Rivera-Benitez, José Francisco; Cuevas-Romero, Sandra; Pérez‐Torres, Armando; Reyes‐Leyva, Julio; Hernández, Jesús; Ramírez‐Mendoza, Humberto

doi:10.1016/j.virusres.2013.05.017

Cited by 9 publications

(12 citation statements)

References 17 publications

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“…No experimental studies have been conducted that would allow us to assess the effects of a secondary infection of SIV in pigs previously infected with PorPV. In a previous study, we showed that PorPV was able to induce a respiratory disease after experimental infection (Rivera-Benitez et al, 2013a). In this study, after infection with PorPV, clinical observations included nasal secretion, conjunctivitis and decreased activity in the first week.…”

Section: Discussionmentioning

confidence: 51%

“…The viral stock was multiplied in the MDCK cell line (Madin-Darby Canine Kidney). The PAC-3 strain of PorPV has been shown to cause respiratory disease and clinical presentations in experimentally infected growing pigs (Rivera-Benitez et al, 2013a). In this study, for coinfection, the A/Swine/New Jersey/11/76 (H1N1) strain (swH1N1) (GenBank access number: K00992-M57477) was used.…”

Section: Viruses and Cellsmentioning

confidence: 99%

“…Viruses that cause respiratory disease and pneumonia in growing pigs include the porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), pseudorabies virus (PRV), porcine rubulavirus (PorPV), porcine circovirus type-2 (PCV-2), and porcine respiratory coronavirus (PRCV). All these viral agents can act individually or through interaction with each other, and associations with other infectious agents of bacterial origin can also occur (Choi et al, 2003;Deblanc et al, 2012;Grau-Roma and Segales, 2007;Kirkland and Stephano, 2006;Morin et al, 1990;Rivera-Benitez et al, 2013a;Segales et al, 1997). PorPV is the etiological agent of blue-eye disease (BED) in pigs.…”

Section: Introductionmentioning

confidence: 99%

“…In growing pigs, the infection becomes established predominantly in the respiratory tract and the central nervous system. In lungs, interstitial pneumonia has been described, and an increase in respiratory signs was observed in experimental infection (Reyes-Leyva et al, 2004;Reyes-Leyva et al, 2002;Rivera-Benitez et al, 2013a;Stephano et al, 1988). Acute swine influenza virus infection causes interstitial pneumonia and bronchiolitis, with cough, dyspnea, fever, and lethargy as clinical manifestations, although recovery is usually rapid.…”

Section: Introductionmentioning

confidence: 99%

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Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus

Rivera-Benitez

Luz-Armendáriz

Saavedra‐Montañez

et al. 2016

Veterinary Microbiology

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Porcine rubulavirus (PorPV) and swine influenza virus infection causes respiratory disease in pigs. PorPV persistent infection could facilitate the establishment of secondary infections. The aim of this study was to analyse the pathogenicity of classic swine H1N1 influenza virus (swH1N1) in growing pigs persistently infected with porcine rubulavirus. Conventional six-week-old pigs were intranasally inoculated with PorPV, swH1N1, or PorPV/swH1N1. A mock-infected group was included. The co-infection with swH1N1 was at 44 days post-infection (DPI), right after clinical signs of PorPV infection had stopped. The pigs of the co-infection group presented an increase of clinical signs compared to the simple infection groups. In all infected groups, the most recurrent lung lesion was hyperplasia of the bronchiolar-associated lymphoid tissue and interstitial pneumonia. By means of immunohistochemical evaluation it was possible to demonstrate the presence of the two viral agents infecting simultaneously the bronchiolar epithelium. Viral excretion of PorPV in nasal and oral fluid was recorded at 28 and 52 DPI, respectively. PorPV persisted in several samples from respiratory tissues (RT), secondary lymphoid organs (SLO), and bronchoalveolar lavage fluid (BALF). For swH1N1, the viral excretion in nasal fluids was significantly higher in single-infected swH1N1 pigs than in the co-infected group. However, the co-infection group exhibited an increase in the presence of swH1N1 in RT, SLO, and BALF at two days after co-infection. In conclusion, the results obtained confirm an increase in the clinical signs of infection, and PorPV was observed to impact the spread of swH1N1 in analysed tissues in the early stage of co-infection, although viral shedding was not enhanced. In the present study, the interaction of swH1N1 infection is demonstrated in pigs persistently infected with PorPV.

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Section: Discussionmentioning

confidence: 51%

Section: Viruses and Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus

Rivera-Benitez

Luz-Armendáriz

Saavedra‐Montañez

et al. 2016

Veterinary Microbiology

Self Cite

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show abstract

“…This swine virus is the causative agent of blue eye disease (BED) that appears with a varied symptomatology depending on the age of the animals. The piglets exhibit neurological and pulmonary symptoms characterized by encephalitis, corneal opacity and/or pneumonia (Mendoza-Magana et al, 2007; Rivera-Benitez et al, 2013; Rodriguez-Ropon et al, 2003; Wiman et al, 1998). In adults, the disease is characterized by symptoms that affect the reproductive system.…”

Section: Introductionmentioning

confidence: 99%

La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation

et al. 2016

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La Piedad Michoacán Mexico Virus (LPMV) is a member of the Rubulavirus genus within the Paramyxoviridae family. LPMV is the etiologic agent of “blue eye disease”, causing a significant disease burden in swine in Mexico with long-term implications for the agricultural industry. This virus mainly affects piglets and is characterized by meningoencephalitis and respiratory distress. It also affects adult pigs, causing reduced fertility and abortions in females, and orchitis and epididymitis in males. Viruses of the Paramyxoviridae family evade the innate immune response by targeting components of the interferon (IFN) signaling pathway. The V protein, expressed by most paramyxoviruses, is a well-characterized IFN signaling antagonist. Until now, there were no reports on the role of the LPMV-V protein in inhibiting the IFN response. In this study we demonstrate that LPMV-V protein antagonizes type I but not type II IFN signaling by binding STAT2, a component of the type I IFN cascade. Our results indicate that the last 18 amino acids of LPMV-V protein are required for binding to STAT2 in human and swine cells. While LPMV-V protein does not affect the protein levels of STAT1 or STAT2, it does prevent the IFN-induced phosphorylation and nuclear translocation of STAT1 and STAT2 thereby inhibiting cellular responses to IFN α/β

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Assessment of the hemagglutinating activity of the Porcine orthorubulavirus

Albarrán-Rodriguez

Castillo‐Juárez

Rivera-Benitez

et al. 2022

Comparative Immunology, Microbiology and Infectious Diseases

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Respiratory disease in growing pigs after Porcine rubulavirus experimental infection

Cited by 9 publications

References 17 publications

Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus

Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus

La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation

Assessment of the hemagglutinating activity of the Porcine orthorubulavirus

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