Respiratory Effects of Intravenous Morphine Infusions in Neonates, Infants, and Children After Cardiac Surgery

Lynn, Anne M; Nespeca, Mary Kay; Opheim, Kent E.; Slattery, John T.

doi:10.1213/00000539-199310000-00007

Cited by 153 publications

(85 citation statements)

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“…24 There is no indication that given equianalgesic doses, morphine causes more side effects than the other opioids. 24 Lynn et al 25 found that neonates, infants and children are most susceptible to respiratory depression following intravenous administration of morphine if the morphine blood concentration was higher than 20 ng/mL. 25,26 Respiration has been found to be depressed several hours after morphine administration, and the onset might not occur until hours after administration.…”

Section: Morphine As An Alternative To Codeinementioning

confidence: 99%

“…24 Lynn et al 25 found that neonates, infants and children are most susceptible to respiratory depression following intravenous administration of morphine if the morphine blood concentration was higher than 20 ng/mL. 25,26 Respiration has been found to be depressed several hours after morphine administration, and the onset might not occur until hours after administration. 27,28 Although severe respiratory depression needing treatment is rare, it can be catastrophic; it is therefore very important to monitor the child's respiration following administration of morphine.…”

Section: Morphine As An Alternative To Codeinementioning

confidence: 99%

See 1 more Smart Citation

Pain Management in Children: Part 2 — A Transition from Codeine to Morphine for Moderate to Severe Pain in Children

et al. 2012

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Section: Morphine As An Alternative To Codeinementioning

confidence: 99%

Section: Morphine As An Alternative To Codeinementioning

confidence: 99%

Pain Management in Children: Part 2 — A Transition from Codeine to Morphine for Moderate to Severe Pain in Children

et al. 2012

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“…90,99 Future studies should examine the influence of administration of perioperative analgesics on the duration of assisted ventilation required, the timing of extubation, and overall respiratory function. [100][101][102] General anesthesia includes achieving unconsciousness (lack of implicit recall and lack of awareness of surgery), analgesia, suppression of autonomic responses to noxious stimuli, and immobility. Studies using general anesthesia in the pediatric age group need to address whether newer agents are safer in the short-term than existing agents and investigate their immediate and long-term postoperative outcomes.…”

Section: Procedural Painmentioning

confidence: 99%

Summary Proceedings From the Neonatal Pain-Control Group

et al. 2006

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Recent advances in neurobiology and clinical medicine have established that the fetus and newborn may experience acute, established, and chronic pain. They respond to such noxious stimuli by a series of complex biochemical, physiologic, and behavioral alterations. Studies have concluded that controlling pain experience is beneficial with respect to short-term and perhaps long-term outcomes. Yet, pain-control measures are adopted infrequently because of unresolved scientific issues and lack of appreciation for the need for control of pain and its long-term sequelae during the critical phases of neurologic maturation in the preterm and term newborn. The neonatal pain-control group, as part of the Newborn Drug Development Initiative (NDDI) Workshop I, addressed these concerns. The specific issues addressed were (1) management of pain associated with invasive procedures, (2) provision of sedation and analgesia during mechanical ventilation, and (3) mitigation of pain and stress responses during and after surgery in the newborn infant. The cross-cutting themes addressed within each category included (1) clinical-trial designs, (2) drug prioritization, (3) ethical constraints, (4) gaps in our knowledge, and (5) future research needs. This article provides a summary of the discussions and deliberations. Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005).www.pediatrics.org/cgi

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“…It is the most important drug of the opiates group 3 . The use of morphine as an analgesic in pre-term newborns is very common, due to the many painful procedures and stressful circumstances they undergo 4,24,25 anditusedforthetherapy of reduce to severe pain, especially aftersurgical procedures. Toxic effects of morphine usage can be harmful for…”

Section: Introductionmentioning

confidence: 99%

Kinetic Spectrophotometric Determination of Morphine in Pharmaceutical Samples

Keyvanfard¹,

Amri²

2014

Orient J Chem

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A new, sensitive, simple, inexpensive and fast kinetic spectrophotometric method was developed for the determination of trace amounts of morphine over the range of 12-60ng/mL. The method is based on the catalytic effect of morphine on the reaction of bromate and methylene bluein acidic media is reported. The reaction was monitored spectrophotometrically by 60 ng/ml measuring the decrease in absorbance of methylene blue at 665 nm with a fixed-time 0.5-2.5 min from initiation of the reaction. The detection limit is 0.8 ng/mL and relative standard deviation of 12and 52ng/mLmorphine for 6 replicate measurements was 1.50 and 0.87%respectively. The method 12 and 52 ng/ml was applied to the determination of morphine inpharmaceutical samples % respectively.

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Respiratory Effects of Intravenous Morphine Infusions in Neonates, Infants, and Children After Cardiac Surgery

Cited by 153 publications

References 0 publications

Pain Management in Children: Part 2 — A Transition from Codeine to Morphine for Moderate to Severe Pain in Children

Pain Management in Children: Part 2 — A Transition from Codeine to Morphine for Moderate to Severe Pain in Children

Summary Proceedings From the Neonatal Pain-Control Group

Kinetic Spectrophotometric Determination of Morphine in Pharmaceutical Samples

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