Respiratory Epithelial Adenomatoid Hamartomas and Chondroosseous Respiratory Epithelial Hamartomas of the Sinonasal Tract: A Case Series and Literature Review

Roffman, Eric; Baredes, Soly; Mirani, Neena

doi:10.2500/ajr.2006.20.2947

Cited by 42 publications

(36 citation statements)

References 17 publications

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“…Although conservative surgical excision of REAH in humans is considered curative, 1 distinguishing hamartomas from inverted papilloma or adenocarcinoma is important to prevent more aggressive surgical approaches. 10 Histologically, the mass in the dog in the current study had criteria for the diagnosis of REAH. The inflammatory infiltrates were considered secondary and were most likely a result of decreased bacterial clearance due to the extensive turbinate loss.…”

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confidence: 81%

Respiratory Epithelial Adenomatoid Hamartoma in a Dog

et al. 2009

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Abstract. A 6-month-old, intact, male Weimaraner dog presented to the veterinary teaching hospital for bilateral mucopurulent ocular and nasal discharge that began at approximately 10 weeks of age. A computed tomography scan showed an expansile soft-tissue mass involving both frontal sinuses, the ethmoid regions, and nasal cavities with lysis of the maxillary turbinates and hyperostosis of the walls of the frontal sinus. The dog was euthanized after complications during a trephination and biopsy procedure. At necropsy, a large, tan, papillary, gelatinous mass filled the entire nasal cavity and frontal sinus. The mass was composed of large fronds of loose fibrovascular stroma covered by a single layer of pseudostratified, columnar, ciliated epithelium and intermixed goblet cells. The cells occasionally formed glandular structures that were continuous with the surface epithelium. The mass was diagnosed as a respiratory epithelial adenomatoid hamartoma based on the morphologic appearance.

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confidence: 81%

Respiratory Epithelial Adenomatoid Hamartoma in a Dog

et al. 2009

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“…It was first described by Wenig and Heffner as a benign overgrowth of submucosal ciliated respiratory lined glands forming a polypoid mass lesion [11]. The majority arise from the posterior nasal septum, more commonly in males between the ages of 27 and 81, who present with obstructive symptoms or epistaxis [9][10][11]. It was suggested that they may be associated with other lesions, such as inverted papilloma and solitary fibrous tumor, but no definite precursor lesions have been identified [3].…”

Section: Discussionmentioning

confidence: 99%

“…In the sinonasal region, hamartomas have been designated as epithelial, mesenchymal, and mixed [3,4]. They include chrondomesenchymal hamartoma [4][5][6][7], respiratory epithelial adenomatoid hamartoma (REAH) [8][9][10][11], and seromucinous hamartoma (SH). Each of these has characteristic features, but occasional lesions will show overlapping features of multiple types.…”

Section: Introductionmentioning

confidence: 99%

Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

Khan

Chernock

Lewis

2011

Head and Neck Pathol

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The sinonasal tract is a complex anatomic site, home to a wide variety of reactive, inflammatory, benign, and malignant lesions. Inflammatory polyps and papillomas are usually easily recognized by pathologists. A poorly understood lesion that has been more clearly defined in recent years is the nasal hamartoma. The epithelial subtypes include seromucinous hamartoma, respiratory epithelial adenomatoid hamartoma, and hybrid lesions. Seromucinous hamartomas have only been recognized and substantially reported over the past few years. They are a diagnostic challenge, needing to be distinguished from low grade adenocarcinomas, and are of interest because most of the basic questions about their pathophysiology remain unanswered. Herein, we present two novel cases of seromucinous hamartoma with features that partly expand the morphologic spectrum of these lesions, discuss the differential diagnosis, and review the literature to compare our findings with previously reported cases with the aim of better understanding this interesting entity.

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“…Examples of so-called COREAH (chondroosseous REAH) have been described, where either cartilage or bone are present within a REAH [7,8], which still could be in keeping with a hamartomatous process given the normal appearance of these structures in the nasal cavity. The chondro-osseous components could alternatively be normal structures entrapped by the REAH rather than a part of the proliferation.…”

Section: Respiratory Epithelial Adenomatoid Hamartomamentioning

confidence: 99%

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

Weinreb

2010

Head and Neck Pathol

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The sinonasal tract is a complex anatomic site with an exhaustive list of possible diagnoses. While most biopsies or resections encountered routinely consist of common diagnoses such as inflammatory polyps and papillomas, occasional cases are more difficult, and separating reactive or benign from malignancy can be challenging. One of the most poorly understood and daunting categories is low grade glandular or tubular proliferations, particularly on small biopsies. Possible diagnoses such as reactive lesions, respiratory epithelial adenomatoid hamartoma (REAH), seromucinous (glandular) hamartoma (SH) and low grade sinonasal adenocarcinomas (LGSNAC) must be entertained. REAH is composed of respiratory epithelial lined submucosal glands with variable connection to the surface and periglandular hyalinization. SH is a tubular proliferation reminiscent of normal serous glands which may be associated with REAH.LGSNAC is a diverse group of bland tubular and/or papillary tumors, which have a recurrence potential but an as yet uncertain potential for metastasis or mortality. The management for these lesions can be vastly different and conservative management is preferable, making this distinction more than academic. However, complicating this category are controversies surrounding their nature as reactive lesions versus neoplasms, the histologic and immunohistochemical overlap, and possible precursor relationships between some of them.

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Respiratory Epithelial Adenomatoid Hamartomas and Chondroosseous Respiratory Epithelial Hamartomas of the Sinonasal Tract: A Case Series and Literature Review

Abstract: Misdiagnosing REAH or CORE hamartoma as either inverted papilloma or adenocarcinoma may lead to far more aggressive surgical intervention then is necessary.

Cited by 42 publications

References 17 publications

Respiratory Epithelial Adenomatoid Hamartoma in a Dog

Respiratory Epithelial Adenomatoid Hamartoma in a Dog

Seromucinous Hamartoma of the Nasal Cavity: A Report of Two Cases and Review of the Literature

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

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