Respiratory Function in Progressive Systemic Sclerosis

Catterall, Mary; Rowell, N. R.

doi:10.1136/thx.18.1.10

Cited by 54 publications

(13 citation statements)

References 9 publications

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“…These findings are consistent with those generally accepted in pulmonary sarcoidosis (16)(17)(18), systemic sclerosis (19)(20)(21), idiopathic interstitial pulmonary fibrosis (22)(23)(24)(25), and other diseases with pulmonary fibrosis (26)(27)(28)(29). A restrictive ventilatory defect has been the most frequently described early abnormality in these diseases.…”

Section: Discussionsupporting

confidence: 80%

Diffusing capacities and ventilation: perfusion ratios in patients with the clinical syndrome of alveolar capillary block

Arndt¹,

King²,

Briscoe³

1970

J. Clin. Invest.

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A B S T R A C T Studies were performed on 10 patients with the clinical syndrome of alveolar capillary block while each patient was breathing four different inspired oxygen mixtures. The data were interpreted using the principle of the Bohr integral isopleth with which alveolar oxygen tension in the differently ventilated parts of the lung can initially be treated as unknown. It is then possible to determine the distribution of ventilation, of perfusion, of diffusing capacity, of lung volume, and of alveolar and end capillary blood oxygen tension in the variously functioning parts of the lung. In two patients shunts were the major factor interfering with oxygen transfer. In four others inequalities in ventilation: perfusion ratios and in diffusing capacity in different parts of the lung were the factors interfering with oxygen transfer. In four more patients ventilation: perfusion ratios were the same throughout the lung, the only disturbance of oxygen transfer being in the total diffusing capacity or in its distribution between the different parts of the lung.

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Section: Discussionsupporting

confidence: 80%

Diffusing capacities and ventilation: perfusion ratios in patients with the clinical syndrome of alveolar capillary block

Arndt¹,

King²,

Briscoe³

1970

J. Clin. Invest.

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“…Small airway disease has been shown to correlate with other abnormalities, such as decreased maximal midexpiratory flow rate (M MFR) (1 5-18), increased residual volume (RV) ( 15,19), increased closing volume (CV), and closing capacity (20,21). It is interesting that several of the authors cited above noted, without comment, increases in RV and residual volume/total lung capacity ratio (RV/TLC) in patients with scleroderma (4,5,7,8).…”

mentioning

confidence: 99%

“…Impaired diffusion has been suggested as the earliest pulmonary function alteration in scleroderma (5,8). Obstructive lung disease has been noted alone or in conjunction with restrictive lung disease (2,4,5,7,9,11), but has been considered a relatively late manifestation of disease (2.8).…”

mentioning

confidence: 99%

Pulmonary Function in Scleroderma

Guttadauria

Ellman

Emmanuel

et al. 1977

Arthritis & Rheumatism

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Pulmonary function tests were performed in 45 patients with scleroderma. Thirteen patients (29%) were found to have restrictive disease, 12 patients (27%) were found to have obstructive disease, and 19 patients (42%) had small airway disease (SAD). Smoking did not seem to be a factor underlying either obstructive or small airway disease in these patients. A low diffusing capacity was most common in patients with restrictive disease and rarely the only abnormality in pulmonary function. S A D was usually found in patients who had normal chest radiographs and no pulmonary symptoms and was often the only abnormality. S A D is therefore an early and sensitive indicator of pulmonary involvement in scleroderma.Since the report by Baldwin et a1 in 1949 (I), restriction of lung volumes and impaired diffusion have been considered the characteristic pulmonary function abnormalities in patients with the pulmonary involvement of scleroderma. Studies since then (2-1 1)

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“…Malaise and posterior subcapsular cataract have been reported as side effects. PFr can be abnormal even when chest radiology shows no abnormality [5] as was in our case.…”

Section: Reply Wmentioning

confidence: 68%