Respiratory health assessment and exposure to polycyclic aromatic hydrocarbons in Mexican indigenous population

Rodríguez-Aguilar, Maribel; León-Martínez, Lorena Díaz de; García-Luna, Sofía; Gómez-Gómez, Alejandro; González-Palomo, Ana Karen; Pérez‐Vázquez, Francisco Javier; Dı́az-Barriga, Fernando; Trujillo, Joyce; Flores-Ramírez, Rogelio

doi:10.1007/s11356-019-05687-w

Cited by 23 publications

(14 citation statements)

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“…Based partly on occurrence and partly on toxicity, special attention has been given to the 16 PAHs classified as priority pollutants (USEPA, 2005): naphthalene, acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benz(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, B[a]P, dibenz(a,h)anthracene, benzo(ghi)perylene and indeno(1,2,3-cd)pyrene. Metabolite levels in blood and urine of low molecular weight PAHs such as pyrene, phenanthrene and naphthalene are often used as surrogates to assess airborne PAH-exposure [27,28]. This is due to the fact that these PAHs to a lesser degree than larger ones are found in food.…”

Section: Introductionmentioning

confidence: 99%

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

et al. 2020

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Epidemiological studies have found strong associations between air pollution and respiratory effects including development and/or exacerbation of asthma and chronic obstructive pulmonary disease (COPD) as well as increased occurrence of respiratory infections and lung cancer. It has become increasingly clear that also polycyclic aromatic hydrocarbons (PAHs) may affect processes linked to non-malignant diseases in the airways. The aim of the present paper was to review epidemiological studies on associations between gas phase and particle-bound PAHs in ambient air and non-malignant respiratory diseases or closely related physiological processes, to assess whether PAH-exposure may explain some of the effects associated with air pollution. Based on experimental in vivo and in vitro studies, we also explore possible mechanisms for how different PAHs may contribute to such events. Epidemiological studies show strongest evidence for an association between PAHs and asthma development and respiratory function in children. This is supported by studies on prenatal and postnatal exposure. Exposure to PAHs in adults seems to be linked to respiratory functions, exacerbation of asthma and increased morbidity/mortality of obstructive lung diseases. However, available studies are few and weak. Notably, the PAHs measured in plasma/urine also represent other exposure routes than inhalation. Furthermore, the role of PAHs measured in air is difficult to disentangle from that of other air pollution components originating from combustion processes. Experimental studies show that PAHs may trigger various processes linked to non-malignant respiratory diseases. Physiological- and pathological responses include redox imbalance, oxidative stress, inflammation both from the innate and adaptive immune systems, smooth muscle constriction, epithelial- and endothelial dysfunction and dysregulated lung development. Such biological responses may at the molecular level be initiated by PAH-binding to the aryl hydrocarbon receptor (AhR), but possibly also through interactions with beta-adrenergic receptors. In addition, reactive PAH metabolites or reactive oxygen species (ROS) may interfere directly with ion transporters and enzymes involved in signal transduction. Overall, the reviewed literature shows that respiratory effects of PAH-exposure in ambient air may extend beyond lung cancer. The relative importance of the specific PAHs ability to induce disease may differ between the biological endpoint in question.

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Section: Introductionmentioning

confidence: 99%

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

et al. 2020

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“…All twelve cross-sectional studies 17 – 18 , 26 , 29 , 34 – 41 reported inclusion and exclusion criteria, source of data, and method of selection of participants. Seven studies 8 , 39 – 40 , 45 , 47 , 48 , 50 did not explain how to control for confounding factors. It is not clear how studies dealt with readings of PAHs below the limit of detection except in Epton et al .…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of Exposure to Polycyclic Aromatic Hydrocarbons and Obstructive Lung Disease

Nwaozuzu

Partick-Iwuanyanwu

Abah

2021

Journal of Health and Pollution

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Background. There is fast-growing epidemiologic evidence of the effects of environmental chemicals on respiratory health. Polycyclic aromatic hydrocarbons (PAHs) have been linked with airway obstruction common in asthma and/or asthma exacerbation, and chronic bronchitis and emphysema. Objectives. A systematic review of the association between exposure to PAHs and obstructive lung diseases is not yet available. The present systematic review aims to evaluate the evidence available in epidemiological studies that have associated PAHs with obstructive lung diseases such as asthma, chronic bronchitis, emphysema. Methods. We performed a systematic literature search on PubMed, Google Scholar, and Scopus databases using relevant keywords and guided by predesigned eligibility criteria. Results. From the total of 30 articles reviewed, 16 articles examined the link between PAHs and lung function in both adults and children. Twelve articles investigated the association between PAHs and asthma, asthma biomarkers, and/or asthma symptoms in children. Two articles studied the relationship between PAHs and fractional exhaled nitric oxide (FeNO), a biomarker of airway inflammation and the relationship between PAHs and obstructive lung diseases and infections, respectively. One study assessed exposure to daily ambient PAHs and cough occurrence. Discussion. Twenty-seven studies found an association between PAHs and asthma and reduced lung function. In children it is reinforced by studies on prenatal and postnatal exposure, whereas in adults, reductions in lung function tests marked by low forced expiratory volume in 1 second, (FEV1), forced vital capacity (FVC), and forced expiratory flow (FEF25–75%) were the major health outcomes. Some studies recorded contrasting results: insignificant and/or no association between the two variables of interest. The studies reviewed had limitations ranging from small sample size, to the use of cross-sectional rather than longitudinal study design. Conclusions. The literature reviewed in the present study largely suggest positive correlations between PAHs and obstructive lung diseases marked mainly by asthma and reduced respiratory function. This review was registered with PROSPERO (Registration no: CRD42020212894) Competing Interests. The authors declare no competing financial interests.

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“…The most common gaseous IAPs include radon, ozone, VOCs (volatile organic compounds), and oxides of carbon, sulphur, and nitrogen, whereas the microbes typically comprise bacteria, fungi, algae, and mold (Ana et al, 2015;Cincinelli et al, 2017). The gaseous and solid IAPs (such as particulate matter, aerosols, carbon black, and soot) typically arise from burning petroleum, coal, and biomass fuels and the use of chemicals, fibers and polymers in automobiles, homes or industrial processes (Cincinelli et al, 2017;Nwanaji-Enwerem et al, 2020;Rodríguez-Aguilar et al, 2019). The main cause of poor indoor air quality in homes is that the gas and solid particulates released into the air are confined or constrained by insulation materials along with ventilation and air conditioning systems installed in modern-day buildings.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the transport of air inside buildings is reduced, whereas the concentration of indoor air pollutants increases over time. Due to the occurrence of IAPs, children, adolescents, and the aged are susceptibly exposed to severe health risks, such as respiratory or cardiovascular sicknesses (Ardiles et al, 2018;Rodríguez-Aguilar et al, 2019). The poor quality of indoor air is also linked to sick building syndrome, declining productivity, and psychological performance (Akova et al, 2020;Sarkhosh et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Potential Sources, Formation Routes, and Health Effects of Nitrogen Dioxide (NO2) on Indoor Air Quality, Human Health, Safety, and the Environment: A Review

2021

DRCSF

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Since human beings spend 80-90% of the day inside houses, educational and recreation centers, office blocks, or automobiles, the quality of air within these buildings or structures is crucial for human health and safety. Hence, indoor air quality (IAQ) highlights the general characteristics of indoor air that affect the state of health, thermal comfort, and well-being of humans. Despite numerous regulatory standards, framework policies, and monitoring plans proposed for IAQ, the occurrence of indoor pollutants including radon (Rn), ozone (O3), and oxides of carbon, sulfur, and nitrogen have become common. Many studies contend that nitrogen dioxide (NO2) is a major indoor air pollutant and one of the most poisonous on Earth. It is a reddish-brown gas generated from the oxidation of nitrogen oxides (NOx) and molecular oxygen or O3 or the high-temperature combustion of solid fuels. This paper presents an overview of the potential sources, formation routes, and health effects of NO2. According to reviewed literature, the occurrence, concentrations, and ratios of NO2 in the indoor environment are affected by residential factors, weather/climate, and proximity to NO2 sources indoors, such as burners, ovens, and stoves. Furthermore, long-term exposure to NO2 causes diabetes, heart, cardiovascular, hypertension diseases, severe cough, hemoptysis, pediatric lung edema and, more recently, fatalities arising from COVID-19. Therefore, the overdependence on polluting fuels that generate NO2 must be minimized or eliminated to improve IAQ and protect human health, safety, and the environment. Future design plans for constructing kitchens, homes, offices, automobiles, factories, and power plants must incorporate smart sensors or ventilation systems for detecting, monitoring, or removal of exhaust gases, including NO2.

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Respiratory health assessment and exposure to polycyclic aromatic hydrocarbons in Mexican indigenous population

Cited by 23 publications

References 50 publications

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases

Systematic Review of Exposure to Polycyclic Aromatic Hydrocarbons and Obstructive Lung Disease

Potential Sources, Formation Routes, and Health Effects of Nitrogen Dioxide (NO2) on Indoor Air Quality, Human Health, Safety, and the Environment: A Review

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