Respiratory hypercapnic-hypoxic training is an effective component of complex therapy of polyneuropathy in children with diabetes type 1

Смирнов, К. В.; Smirnova, Yu. V.; Kulikov, V. V.; Nazarkina, O. M.

doi:10.17116/jnevro20181183132-38

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…For example, in a randomized triple-blind placebo-controlled study, respiratory training with hypercapnic hypoxia was shown to have a positive effect on the functional state of the nervous system in children with cerebral palsy and can be used as a means to increase the effectiveness of standard therapy for these patients [187]. Additionally, the effectiveness of hypercapnic hypoxia has been demonstrated in the treatment of diabetic polyneuropathy in pediatric patients [188]. Such efficacy is likely associated with the high neuroplasticity and adaptogenic potential in childhood [189].…”

Section: Future Directions and Potential For Clinical Applicationmentioning

confidence: 99%

Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia

Tregub,

Kulikov,

Ibrahimli

et al. 2024

IJMS

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The review introduces the stages of formation and experimental confirmation of the hypothesis regarding the mutual potentiation of neuroprotective effects of hypoxia and hypercapnia during their combined influence (hypercapnic hypoxia). The main focus is on the mechanisms and signaling pathways involved in the formation of ischemic tolerance in the brain during intermittent hypercapnic hypoxia. Importantly, the combined effect of hypoxia and hypercapnia exerts a more pronounced neuroprotective effect compared to their separate application. Some signaling systems are associated with the predominance of the hypoxic stimulus (HIF-1α, A1 receptors), while others (NF-κB, antioxidant activity, inhibition of apoptosis, maintenance of selective blood–brain barrier permeability) are mainly modulated by hypercapnia. Most of the molecular and cellular mechanisms involved in the formation of brain tolerance to ischemia are due to the contribution of both excess carbon dioxide and oxygen deficiency (ATP-dependent potassium channels, chaperones, endoplasmic reticulum stress, mitochondrial metabolism reprogramming). Overall, experimental studies indicate the dominance of hypercapnia in the neuroprotective effect of its combined action with hypoxia. Recent clinical studies have demonstrated the effectiveness of hypercapnic–hypoxic training in the treatment of childhood cerebral palsy and diabetic polyneuropathy in children. Combining hypercapnic hypoxia with pharmacological modulators of neuro/cardio/cytoprotection signaling pathways is likely to be promising for translating experimental research into clinical medicine.

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Section: Future Directions and Potential For Clinical Applicationmentioning

confidence: 99%

Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia

Tregub,

Kulikov,

Ibrahimli

et al. 2024

IJMS

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show abstract

“…The available literature lacks information on the effect of hypoxia and especially hypercapnia on diabetes mellitus and carbohydrate metabolism. Smirnov et al showed that hypercapnic-hypoxic training (2 hours a day) reduces blood glucose levels and promotes the treatment of type 1 diabetes mellitus and concomitant polyneuropathy in children [67].…”

Section: Life Extensionmentioning

confidence: 99%

Therapeutic hypercapnia. Review

Tolstun

Muradian

Bezrukov

2022

A&L

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In recent years, interest in hypercapnia and its practical applications has grown significantly. An analysis of literature data shows a wide range of systemic and local applications. Due to its powerful effect on blood circulation, vascular elasticity, activation of angiogenesis, and inhibition of pro-inflammatory factors, hypercapnia is already used in dermatology, phlebology, and therapy. Wide opportunities open up for practical use in neurology, given the powerful neuroprotective effect of carbon dioxide, which not only increases tolerance to ischemia, preventing the development of diseases but can also become a tool for the treatment of stroke and heart attack. The antitumor effect and the ability to reduce the level of metabolic processes also make hypercapnia an attractive geroprotector that will help in solving the issue of life extension. Keywords: hypercapnia; hypoxia; cancer; diabetes; neuroprotection; longevity; carboxytherapy; ischemia; stroke

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Hypercapnic hypoxia improves cognitive and motor functions of children with cerebral palsy

Kulikov

Tregub

Parshin

et al. 2022

Neurological Research

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Respiratory hypercapnic-hypoxic training is an effective component of complex therapy of polyneuropathy in children with diabetes type 1

Cited by 4 publications

References 13 publications

Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia

Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia

Therapeutic hypercapnia. Review

Hypercapnic hypoxia improves cognitive and motor functions of children with cerebral palsy

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