Respiratory illnesses in early life and asthma and atopy in childhood

Ramsey, Clare D.; Gold, Diane R.; Litonjua, Augusto A.; Sredl, Diane; Ryan, Louise; Celedón, Juan C.

doi:10.1016/j.jaci.2006.09.012

Cited by 58 publications

(45 citation statements)

References 50 publications

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“…Our finding of an inverse association between each of two early-life exposures (indoor endotoxin levels at age 2-3 months and physician-diagnosed croup in the first year of life) and allergic rhinitis at age 9 years confirm and extend our previous findings in this cohort at age 7 years 25,26 .…”

Section: Discussionsupporting

confidence: 89%

“…Additional variables considered for inclusion in the multivariate analysis included sex, annual household income 21 , child's ethnicity 21 , number of older siblings, maternal age at delivery, gestational age 20 , maternal asthma (ever and current), paternal asthma (ever and current), in utero smoke exposure, average number of cigarettes smoked by adults in the household per day, breast feeding 22 , day care attendance in the first year of life 23 , antibiotic use in the first year of life 24 , bottle feeding in the crib or bed prior to sleep 22 , physician-diagnosed illnesses of the upper (sinusitis and recurrent [≥3 episodes] of nasal catarrh) and lower (pneumonia, bronchiolitis, bronchitis, and croup) respiratory tract in the first year of life 25 , and levels of dust mite allergen and endotoxin in house dust at age 2 to 3 months 26 . The methods used to collect house dust samples and quantify levels of dust mite allergen (in the child's bed) and endotoxin (in the family/living room) have been previously described [26][27][28][29] .…”

Section: Definition Of Other Variablesmentioning

confidence: 99%

See 1 more Smart Citation

Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy

Pistiner

Gold

Abdulkerim

et al. 2008

Journal of Allergy and Clinical Immunology

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152

104

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Section: Discussionsupporting

confidence: 89%

Section: Definition Of Other Variablesmentioning

confidence: 99%

Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy

Pistiner

Gold

Abdulkerim

et al. 2008

Journal of Allergy and Clinical Immunology

Self Cite

152

104

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show abstract

“…However, as the number of infants with BPD was low, it is impossible to make any comment related to the influence of BPD on wheezing, BA, and atopy. There is controversy related to the mechanism of the association between prematurity and allergy, BA, and atopy indicated by different studies (7,8,11,12,20,(31)(32)(33)(34)(35). The results of various studies and proposed mechanisms of atopy and allergic disease in premature infants involved genetic, perinatal origins, and environmental factors (36).…”

Section: Discussionmentioning

confidence: 99%

Wheezing, asthma, and atopy in premature infants at 2 years of age

et al. 2017

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Background/aim: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a crosssectional study.Materials and methods: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records.Results: There were 98 infants, with mean birth weight (BW) 1517.4 ± 486.5 g and GA 30.8 ± 2.9 weeks. The frequencies of wheezing, asthma, and bronchopulmonary dysplasia (BPD) were 32.7%, 16.3%, and 14.3%, respectively. Skin-prick tests were positive for 11 subjects, with allergy to cereals for 7 infants, egg for 3, and peanut for 1. Wheezing was related to GA, BW, respiratory distress syndrome, mechanical ventilation, sepsis, asphyxia, smoking, antenatal steroid, BA, palivizumab prophylaxis, number of people in the household, and duration of hospitalization (P < 0.05). Wheezing was negatively correlated to GA. Family history of BA, smoking, and number of people in the household were linked to BA (P < 0.05). Conclusion:Wheezing was related to degree of premature birth, but BA was linked to BA in the family and smoking. Increased gestation should improve the infant's respiratory health up to 2 years of age.

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“…2,3 In addition to their acute effects, LRTIs in infancy have also been associated with long-term outcomes, such as the development of childhood wheezing illnesses (including asthma). [4][5][6][7] This association is likely influenced by the specific infectious agent, the timing and/or severity of the infection, and certain host factors that may alter susceptibility to infection (e.g., family history of asthma), [7][8][9] but the precise underlying mechanisms remain largely unknown. Furthermore, although between 30% and 50% of infants with LRTIs subsequently develop childhood wheezing illnesses, [9][10][11] it is currently not possible to identify infants at risk for these long-term outcomes.…”

mentioning

confidence: 99%

Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower Respiratory Tract Infections in Infancy

Rosas‐Salazar

Gebretsadik

Carroll

et al. 2015

Pediatric Allergy, Immunology, and Pulmonology

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Background: Infants with lower respiratory tract infections (LRTIs) are at an increased risk of developing childhood wheezing illnesses (including asthma), but it is not currently possible to predict those at risk for these long-term outcomes. The current objective was to examine whether urine levels of club cell 16-kDa secretory protein (CC16) at the time of an infant LRTI are associated with the development of childhood wheezing illnesses. Methods: Prospective study of 133 previously healthy infants enrolled during a healthcare visit for a LRTI and followed longitudinally for childhood wheezing illnesses. Urine levels of CC16 at the time of enrollment were measured after validating a commercially available enzyme-linked immunosorbent assay kit for serum. The outcome of interest was parental report of subsequent childhood wheeze (defined as ‡1 episode of wheezing following the initial LRTI) at the 1-year follow-up visit. Logistic regression was used for the main analysis. Results: The median (interquartile range) urine levels of CC16 (ng/mg of creatinine) at the time of an infant LRTI were 11.1 (7.7-20.1) for infants with subsequent childhood wheeze and 13.4 (8.3-61.1) for those without ( p = 0.11). In the main multivariate analysis using a logarithmic transformation of the urine levels of CC16, a twofold increase in urine levels of CC16 was associated with *30% decreased odds (OR = 0.74 [95% confidence interval (CI) 0.56-0.98], p = 0.04) of subsequent childhood wheeze after adjustment for potential confounders. Conclusions: An inverse association was found between urine levels of CC16 at the time of an infant LRTI and the odds of subsequent childhood wheeze. Urine CC16 may be a useful biomarker of the development of childhood wheezing illnesses after LRTIs in infancy.

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Respiratory illnesses in early life and asthma and atopy in childhood

Cited by 58 publications

References 50 publications

Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy

Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy

Wheezing, asthma, and atopy in premature infants at 2 years of age

Urine Club Cell 16-kDa Secretory Protein and Childhood Wheezing Illnesses After Lower Respiratory Tract Infections in Infancy

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