Respiratory insufficiency in a newborn with mesenchymal hamartoma of the chest wall occupying the thoracic cavity

Shimotake, Takashi; Fumino, Shigehisa; Aoi, Shigeyoshi; Tsuda, Tomoki; Iwai, Naoharu

doi:10.1016/j.jpedsurg.2005.01.022

Cited by 17 publications

(28 citation statements)

References 13 publications

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“…A pleuropulmonary blastoma has a cystic appearance in most of cases (except type III blastomas, which can be solid), which was absent in this case. Furthermore, there was no relationship with the pleura, focal stromal hypercellularity, or sarcomatous appearance, characteristics that are also described in blastomas (including solid type III blastomas) [1,[4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Congenital Peribronchial Myofibroblastic Tumor: A Case Report

Noronha

Cecílio²,

Silva³

et al. 2010

Pediatr Dev Pathol

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We describe a rare occurrence of congenital peribronchial myofibroblastic tumor of the lung presenting in early fetal life. A female patient in the 24th week of gestation who presented with polyhydramnios was admitted for examination. Ultrasound examination revealed a mass compromising the lungs. Because the intrauterine fetal death was revealed by the ultrasound, delivery was induced. Necropsy revealed a pulmonary lesion compromising the left lower pulmonary lobe together with hepatomegaly. Microscopic analysis of the lung showed a lesion with a storiform arrangement of spindle cells with focal peribronchial distribution. Hepatic architecture was diffusely altered by fibrotic tissue. Immunohistochemical analysis on the pulmonary lesion showed high vimentin positivity in the fusocellular components, pointing to the mesenchymal nature of the lesion. Significant differentiation of smooth muscle tissue, as indicated by high HHF35 positivity, was also observed. Electron microscopy on the pulmonary lesion revealed elongated cells with some cytoplasmatic processes, a finding that is also compatible with mesenchymal differentiation.

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Section: Discussionmentioning

confidence: 99%

Congenital Peribronchial Myofibroblastic Tumor: A Case Report

Noronha

Cecílio²,

Silva³

et al. 2010

Pediatr Dev Pathol

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“…Treatment regimens for MSRCTs and RMS act to control the local disease and distant spread. Shimotake et al (24) reported that the local control of MSRCTs could be achieved with radiotherapy, depending on the location, size and volume of the primary tumor, whereas Paulino et al (18) demonstrated that doses of 5,000-6,000 cGy exhibited 80-85% effectiveness in patients. The majority of the selected patients in the present study were administered different doses of radiotherapy, ranging from 1,300 to 4,800 cGy, and the overall survival rates were ~65% (Fig.…”

Section: Discussionmentioning

confidence: 99%

Chest wall tumors: Diagnosis, treatment and reconstruction

Lin

Huang

et al. 2015

Experimental and Therapeutic Medicine

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The aim of the present study was to determine a suitable procedure for the treatment of chest wall neoplasms with less potential risk and an increased rate of survival. Fifty patients with suspected chest wall malignancies were analyzed using various preliminary investigation tools. Whole-chest scanning was performed in all the patients. The patients were subsequently subjected to biopsies for further confirmation of the neoplasm. All such patients were then treated with a surgical approach and radiation therapy, with a follow-up period lasting up to six years. The majority of the patients showed improved survival rates relative to conventional therapies. The survival rates of patients suffering from osteosarcoma (78%) were higher those of patients with rhabdomyosarcoma (73%) and malignant small round cell tumors (64%). The survival and the mortality rates of the patients with synovial sarcoma and fibrosarcoma were the same. This study, which was conducted on a small group of patients, has provided guidance for further studies on tumors of the chest wall, which may, in turn, increase the longevity of affected patients.

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“…The characteristics of the fetal tumor in the present case report were compatible with a type I CAM. The incidence of CAMs is 1 : 5000 live-born neonates [7]. …”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Hamartoma: Prenatal and Postnatal Diagnosis by Imaging

Martínez-Varea

Vila-Vives

Hidalgo-Mora

et al. 2012

Case Reports in Obstetrics and Gynecology

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We present a case of a twin pregnancy in which one fetus developed a rapidly growing unilateral intrathoracic tumor. While a cystic adenomatoid malformation was suspected in the ultrasound scan, the magnetic resonance scan suggested a pulmonary blastoma or a bronchioalveolar carcinoma. Postnatal chest radiography and contrast-enhanced computed tomography of the affected newborn were performed, and it was ruled out the possibility of malignant origin. Finally, the anatomopathologic exam revealed the presence of a mesenchymal hamartoma in the chest wall. Nevertheless, parents refused any treatment for the newborn.

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Respiratory insufficiency in a newborn with mesenchymal hamartoma of the chest wall occupying the thoracic cavity

Cited by 17 publications

References 13 publications

Congenital Peribronchial Myofibroblastic Tumor: A Case Report

Congenital Peribronchial Myofibroblastic Tumor: A Case Report

Chest wall tumors: Diagnosis, treatment and reconstruction

Mesenchymal Hamartoma: Prenatal and Postnatal Diagnosis by Imaging

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