Respiratory morbidity and mortality of traumatic cervical spinal cord injury at a level I trauma center in India

Sengupta, Deep; Bindra, Ashish; Kumar, Niraj; Goyal, Keshav; Singh, Pankaj Kumar; Chaturvedi, Arvind; Malhotra, Rajesh; Mishra, Ashwani Kumar

doi:10.1038/s41394-020-00371-5

Cited by 5 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sengupta D et al [54] showed in their descriptive retrospective study that in patients with cervical spinal cord injury in low-middle-income countries (LMIC), ventilation exposure, hospitalization, and mortality are high and the main cause of mortality among them is due to poor AIS values, extended VD, intensive care and hospital stays, comprehensive CSCI rehabilitation programs are required to overcome this situation.…”

Section: Indian Epidemiological Datamentioning

confidence: 99%

Spinal Cord Injury Prevalence and Treatment Modalities

Ara¹,

Singh²,

Raj³

et al. 2023

Spinal Cord Injury - Current Trends in Acute Management, Function Preservation and Rehabilitation Protocols

View full text Add to dashboard Cite

Spinal cord injury (SCI) is a devasting neurological condition producing physical dependency, morbidity, psychological stress, and financial burden. During the last 30 years, its global prevalence has increased from 236 to 1298 cases per million populations. Two types of spinal cord injury are primary and secondary injury. Primary injury is mechanical damage to the cord itself whereas secondary injury results from one or more biochemical and cellular processes that are triggered by the primary lesion. In 1700 BC, in an Egyptian surgical papyrus, they describe the frustration of health care professionals in treating a severe spinal cord injury, the Papyrus reported spinal fractures as a “disease that should not be treated”. Most of these studies approach a patient with acute spinal cord injury (ASCI) in one of four manners: corrective surgery or a physical, biological, or pharmacological treatment method. Science is unraveling the mechanisms of cell protection and neuroregeneration, but clinically, we only provide supportive care for patients with spinal cord injuries. By combining these treatments, researchers attempt to enhance the functional recovery of patients with spinal cord injuries. Advances in the last decade have allowed us to encourage the development of experimental studies in the field of spinal cord regeneration. The combination of several therapeutic strategies should, at a minimum, allow for partial functional recoveries for these patients, which could improve their quality of life. More studies were done on spinalized animals that indicate that most of these pharmacological agents may act on receptors present in the spinal cord, thus facilitate to produce coordinated locomotor movement, whereas some other drugs used to improve the neuropathological changes caused because of spinal cord injury (SCI), such as spasticity or demyelination, to improve walking.

show abstract

Section: Indian Epidemiological Datamentioning

confidence: 99%

Spinal Cord Injury Prevalence and Treatment Modalities

Ara¹,

Singh²,

Raj³

et al. 2023

Spinal Cord Injury - Current Trends in Acute Management, Function Preservation and Rehabilitation Protocols

View full text Add to dashboard Cite

show abstract

“…Acute traumatic spinal cord injury (SCI) affects approximately 54 people per million in the United States per year, which equates to 18,000 new cases of SCI yearly. Although not the most common type of acute neurotrauma, it has a high rate of long-term disability and an increase in mortality risk of 2–5 times with the highest risk of death occurring in the first year [ 1 , 2 , 3 ]. Risk factors associated with mortality from SCI include the level of injury, tetraplegia, older age, polytrauma, mechanical ventilation, tracheostomy, septicemia, respiratory complications, and cardiovascular complications [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Complications and Weaning Considerations for Patients with Spinal Cord Injuries: A Narrative Review

Hendershot

O’Phelan

2022

JPM

View full text Add to dashboard Cite

Respiratory complications following traumatic spinal cord injury are common and are associated with high morbidity and mortality. The inability to cough and clear secretions coupled with weakened respiratory and abdominal muscles commonly leads to respiratory failure, pulmonary edema, and pneumonia. Higher level and severity of the spinal cord injury, history of underlying lung pathology, history of smoking, and poor baseline health status are potential predictors for patients that will experience respiratory complications. For patients who may require prolonged intubation, early tracheostomy has been shown to lead to improved outcomes. Prediction models to aid clinicians with the decision and timing of tracheostomy have been shown to be successful but require larger validation studies in the future. Mechanical ventilation weaning strategies also require further investigation but should focus on a combination of optimizing ventilator setting, pulmonary toilet techniques, psychosocial well-being, and an aggressive bowel regimen.

show abstract