Respiratory morbidity, lung function and fitness assessment after bronchopulmonary dysplasia

Praprotnik, Marina; Gantar, Irena Štucin; Lučovnik, Miha; Avčin, Tadej; Krivec, Uroš

doi:10.1038/jp.2015.124

Cited by 24 publications

(21 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 6042 article titles were identified of which 183 full articles were screened for inclusion. Nineteen met the inclusion criteria (Figure ) . For the three studies that overlapped data were kindly supplied by the authors .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Course

Kotecha

2019

Pediatric Pulmonology

View full text Add to dashboard Cite

Background Decreased lung function is common in preterm‐born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm‐born children and adults who did or did not have chronic lung disease of prematurity (CLD) in infancy with term‐born controls. Methods We searched eight databases up to February 2018. Studies comparing FeNO levels in preterm‐born subjects (<37 weeks’ gestation) in childhood and adulthood with and without (CLD) with term‐born subjects were identified and extracted by two reviewers. Data were analysed using Review Manager v5.3. Results From 6042 article titles, 183 full articles were screened for inclusion. Nineteen studies met the inclusion criteria. Seventeen studies compared FeNO levels in preterm‐ and term‐born children and adults; 11 studies (preterm n = 640 and term n = 4005) were included in a meta‐analysis. The mean FeNO concentration difference between the preterm‐born and term‐born group was −0.74 (95% CI −1.88 to 0.41) ppb. For the six studies reporting data on CLD (preterm n = 204 and term n = 211) the mean difference for FeNO levels was −2.82 (95% CI −5.87 to 0.22) ppb between the preterm‐born CLD and term‐born groups. Conclusions Our data suggest that preterm born children with and without CLD have similar FeNO levels to term‐born children suggesting an alternative mechanism to eosinophilic inflammation for symptoms of wheezing and airway obstruction observed in preterm‐born subjects.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Medians and IQRs or ranges were converted to means and standard deviations for three studies . Mean and 95% CI were converted to mean and standard deviation for one study …”

Section: Resultsmentioning

confidence: 99%

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Course

Kotecha

2019

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…The proportion of children with a reduced FEV 1 < 80% were preterm BPD group (68%), preterm no BPD (24%) and healthy controls (15%, P < 0.001). There was no significant difference between preterm no BPD and healthy controls (24% vs. 15%, P = 0.35) …”

Section: Lung Function Outcomesmentioning

confidence: 75%

Bronchopulmonary dysplasia: A review of the pulmonary sequelae in the post‐surfactant era

Haggie

Robinson

Selvadurai

et al. 2020

J Paediatrics Child Health

View full text Add to dashboard Cite

We describe the respiratory complications of bronchopulmonary dysplasia (BPD) in childhood and adolescence. The pathophysiology of bronchopulmonary dysplasia has evolved in the era of modern neonatal intensive care. In this review, we aim to summarise the contemporary evidence base and describe the common respiratory morbidities related to BPD including; home oxygen therapy, rehospitalisation, asthma and exercise limitation.

show abstract

“…Using the reference equation VO 2 max = 4.19 (95% CI, 1.12‐7.17) + 0.025 (95% CI, 0.018‐0.031) distance, 26 the difference in exercise capacity of 159 m would equate to a VO 2 max difference of approximately 8.2 mL min −1 kg −1 . In addition, others have shown that measures of exercise capacity, rather than VO 2 max, are also reduced in prematurely born individuals 28 . In one study, 178 preterm and 218 full‐term were monitored annually between eight and 18 years of age.…”

Section: Discussionmentioning

confidence: 99%

Lung function and exercise capacity in prematurely born young people

Harris

Lunt

Bisquera

et al. 2020

Pediatric Pulmonology

View full text Add to dashboard Cite

Objectives To determine if lung function abnormalities in young people born very prematurely routinely exposed to antenatal corticosteroids and postnatal surfactant were associated with reduced exercise capacity. Working Hypothesis In the current era, lung function abnormalities would not be associated with exercise intolerance Study Design Follow‐up of young people from the United Kingdom Oscillation study (UKOS). Patient‐Subject Selection One hundred twenty‐six young people of 797 recruited to UKOS, born at a mean gestational age of 27 weeks were assessed at a mean age of 17 years. Methodology Forced expiratory flow at 75% of the expired vital capacity (FEF75), forced expiratory volume in 1 second (FEV1) and lung volumes (forced vital capacity [FVC]) and residual volume (RV) and functional residual capacity (FRCpleth) were assessed. Abnormal lung function was below the fifth centile and very abnormal lung function below the 2.5th centile. Exercise capacity was assessed using a modified shuttle sprint test and self‐reported hours of exercise. Results Thirty‐nine young people had an abnormal FEF75 with an adjusted reduction in sprint distance of 114 m (P = .018) and an adjusted difference in self‐reported exercise of 0.73 hours (P = .036). Twenty‐seven young people had a very abnormal FEF75 with an adjusted reduction in sprint distance of 159 m (P = .002) and adjusted reduction in self‐reported exercise of 1.15 hours (P = .002). Conclusion Very prematurely born young people with abnormal airway function had a significant reduction in exercise capacity.

show abstract

Respiratory morbidity, lung function and fitness assessment after bronchopulmonary dysplasia

Abstract: More frequent wheezing and reduced lung function persist into school age after BPD.

Cited by 24 publications

References 32 publications

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Fractional exhaled nitric oxide in preterm‐born subjects: A systematic review and meta‐analysis

Bronchopulmonary dysplasia: A review of the pulmonary sequelae in the post‐surfactant era

Lung function and exercise capacity in prematurely born young people

Contact Info

Product

Resources

About