Respiratory Muscle Plasticity

Gransee, Heather M.; Mantilla, Carlos B.; Sieck, Gary C.

doi:10.1002/cphy.c110050

Cited by 31 publications

(33 citation statements)

References 279 publications

(233 reference statements)

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“…Reversal of respiratory muscle dysfunction is an attractive mechanism underlying the protective effects of HIIT in thoracic surgical patients. Indeed, weakness of the respiratory muscles has been consistently reported in patients with low preoperative peakV : O 2 and COPD, 38 which are two features identified as independent predictors of pulmonary complications in the current trial. Using similar short-term total-body aerobic reconditioning programs, Dunham et al reported up to a 40% increase in maximal inspiratory pressure, with the HIIT modality providing a time-efficient alternative to endurance training in increasing both CRF and respiratory muscle function.…”

Section: February 2017mentioning

confidence: 60%

Short-Term Preoperative High-Intensity Interval Training in Patients Awaiting Lung Cancer Surgery: A Randomized Controlled Trial

Licker

Karenovicŝ

Diaper

et al. 2017

Journal of Thoracic Oncology

191

236

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Section: February 2017mentioning

confidence: 60%

Short-Term Preoperative High-Intensity Interval Training in Patients Awaiting Lung Cancer Surgery: A Randomized Controlled Trial

Licker

Karenovicŝ

Diaper

et al. 2017

Journal of Thoracic Oncology

191

236

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“…Each motor unit type is composed of muscle fibers that are homogeneous with respect to their metabolic properties and contractile protein composition, specifically the expression of myosin heavy chain (MyHC) isoforms (Enad et al, 1989; Gransee et al, 2012; Greising et al, 2012; Sieck, 1994; Sieck et al, 1989a, 1996). In fact, this relationship forms the basis of muscle fiber type classification (Brooke and Kaiser, 1970; Edstrom and Kugelberg, 1968; Schiaffino et al, 1989; Sieck et al, 1985).…”

Section: Muscle Fiber Type and Motor Unit Classificationmentioning

confidence: 99%

“…2). Based on our model of DIAm motor unit recruitment, both eupneic ventilation and ventilation stimulated by a hypoxic-hypercapnic gas mixture (10% O 2 , 5% CO 2 , balance N 2 ) require the recruitment of only type S and FR motor units, whereas higher force non-ventilatory motor behaviors require the additional recruitment of more fatigable type FInt and FF motor units (Fournier and Sieck, 1988a; Gransee et al, 2012; Greising et al, 2012; Mantilla et al, 2010; Mantilla and Sieck, 2011; Sieck, 1988, 1989, 1990, 1991, 1994, 1995; Sieck et al, 1989a, 2013; Sieck and Fournier, 1989; Sieck and Gransee, 2012). …”

Section: Muscle Fiber Type and Motor Unit Classificationmentioning

confidence: 99%

Functional impact of sarcopenia in respiratory muscles

Elliott

Greising

Mantilla

et al. 2016

Respiratory Physiology & Neurobiology

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The risk for respiratory complications and infections is substantially increased in old age, which may be due, in part, to sarcopenia (aging-related weakness and atrophy) of the diaphragm muscle (DIAm), reducing its force generating capacity and impairing the ability to perform expulsive non-ventilatory motor behaviors critical for airway clearance. The aging-related reduction in DIAm force generating capacity is due to selective atrophy of higher force generating type IIx and/or IIb muscle fibers, whereas lower force generating type I and IIa muscle fiber sizes are preserved. Fiber type specific DIAm atrophy is also seen following unilateral phrenic nerve denervation and in other neurodegenerative disorders. Accordingly, the effect of aging on DIAm function resembles that of neurodegeneration and suggests possible common mechanisms, such as the involvement of several neurotrophic factors in mediating DIAm sarcopenia. This review will focus on changes in two neurotrophic signaling pathways that represent potential mechanisms underlying the aging-related fiber type specific DIAm atrophy.

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“…The Akt signaling pathway has been evaluated in diaphragm muscle under conditions of hypertrophy and atrophy of muscle fibers. For example, following unilateral denervation of the diaphragm muscle there is an initial phase of muscle hypertrophy followed by subsequent muscle atrophy (156, 240, 290, 358, 484). Of note, following denervation, Akt phosphorylation with downstream activation of mTOR and p70S6K is unchanged but protein degradation rate decreases leading to a net positive protein balance and transient fiber hypertrophy (9).…”

Section: Molecular Determinants Of Muscle Protein Balancementioning

confidence: 99%

Mechanical Properties of Respiratory Muscles

Sieck

Ferreira

Reid

et al. 2013

Comprehensive Physiology

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Striated respiratory muscles are necessary for lung ventilation and to maintain the patency of the upper airway. The basic structural and functional properties of respiratory muscles are similar to those of other striated muscles (both skeletal and cardiac). The sarcomere is the fundamental organizational unit of striated muscles and sarcomeric proteins underlie the passive and active mechanical properties of muscle fibers. In this respect, the functional categorization of different fiber types provides a conceptual framework to understand the physiological properties of respiratory muscles. Within the sarcomere, the interaction between the thick and thin filaments at the level of cross-bridges provides the elementary unit of force generation and contraction. Key to an understanding of the unique functional differences across muscle fiber types are differences in cross-bridge recruitment and cycling that relate to the expression of different myosin heavy chain isoforms in the thick filament. The active mechanical properties of muscle fibers are characterized by the relationship between myoplasmic Ca2+ and cross-bridge recruitment, force generation and sarcomere length (also cross-bridge recruitment), external load and shortening velocity (cross-bridge cycling rate), and cross-bridge cycling rate and ATP consumption. Passive mechanical properties are also important reflecting viscoelastic elements within sarcomeres as well as the extracellular matrix. Conditions that affect respiratory muscle performance may have a range of underlying pathophysiological causes, but their manifestations will depend on their impact on these basic elemental structures.

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Respiratory Muscle Plasticity

Cited by 31 publications

References 279 publications

Short-Term Preoperative High-Intensity Interval Training in Patients Awaiting Lung Cancer Surgery: A Randomized Controlled Trial

Short-Term Preoperative High-Intensity Interval Training in Patients Awaiting Lung Cancer Surgery: A Randomized Controlled Trial

Functional impact of sarcopenia in respiratory muscles

Mechanical Properties of Respiratory Muscles

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