Respiratory muscle plasticity

Rowley, Katharine L.; Mantilla, Carlos B.; Sieck, Gary C.

doi:10.1016/j.resp.2005.03.003

Cited by 42 publications

(42 citation statements)

References 241 publications

(308 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This has been suggested as a key difference between the effects on muscle tissue in the ICU patients and rodent models where denervation or tetrodotoxin treatments are used to induce muscle inactivity [40]. In the experimental model used in this study, limb muscles are unloaded, alpha-motoneurones are intact and the vesicle release from the terminal axon is maintained [9].…”

Section: Musclementioning

confidence: 99%

“…Respiratory muscles differ in their physiological demands compared with postural and locomotor muscles; the continuous motor activity during respiration makes them among the most active skeletal muscles in the body [40]. The effects of mechanical ventilation on diaphragm structure, function and myofibrillar protein and mRNA expression have received significant attention in the past decade, but information on the intercostal muscles is sparse.…”

Section: Effects Of Nmb On Different Muscles and Muscle Typesmentioning

confidence: 99%

See 1 more Smart Citation

Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression

Norman

Nordquist

Andersson

et al. 2006

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

To analyse mechanisms of muscle wasting in intensive care unit patients, we developed an experimental model where rats were pharmacologically paralysed by post-synaptic block of neuromuscular transmission (NMB) and mechanically ventilated for 9+/-2 days. Specific interest was focused on the effects on protein and mRNA expression of sarcomeric proteins, i.e., myosin heavy chain (MyHC), actin, myosin-binding protein C (MyBP-C) and myosin-binding protein H (MyBP-H) in fast- and slow-twitch limb, respiratory and masticatory muscles. Muscle-specific differences were observed in response to NMB at both the protein and mRNA levels. At the protein level, a decreased MyHC-to-actin ratio was observed in all muscles excluding the diaphragm, whereas at the mRNA level a decreased expression of the dominating MyHC isoform(s) was observed in the hind limb and intercostal muscles, but not in the diaphragm and masseter muscles. MyBP-C mRNA expression was decreased in the limb muscles, but it otherwise remained unaffected. MyBP-H conversely increased in all muscles. Furthermore, we found myofibrillar protein and mRNA expression to be affected differently when comparing NMB animals with peripherally denervated (DEN) ambulatory rats. We report that NMB has both a larger and different impact on muscle, at the protein and mRNA levels, than DEN has.

show abstract

Section: Musclementioning

confidence: 99%

Section: Effects Of Nmb On Different Muscles and Muscle Typesmentioning

confidence: 99%

Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression

Norman

Nordquist

Andersson

et al. 2006

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

show abstract

“…following C2HS. Indeed, even when both phrenic nerves are intact, C2HS injury causes a robust enhancement of contralateral phrenic output (8,15,36,39).We reasoned, therefore, that measuring inspiratory V T immediately before and after an acute ipsilateral phrenicotomy procedure could enable a more definitive assessment of the functional significance of the sCPP. In other words, the immediate (i.e., "next breath") drop in V T resulting from disruption of the sCPP should provide a quantitative estimate of its importance.…”

mentioning

confidence: 99%

“…following C2HS. Indeed, even when both phrenic nerves are intact, C2HS injury causes a robust enhancement of contralateral phrenic output (8,15,36,39).…”

mentioning

confidence: 99%

Contribution of the spontaneous crossed-phrenic phenomenon to inspiratory tidal volume in spontaneously breathing rats

Dougherty

Lee

Lane

et al. 2012

Journal of Applied Physiology

View full text Add to dashboard Cite

Dougherty BJ, Lee KZ, Lane MA, Reier PJ, Fuller DD. Contribution of the spontaneous crossed-phrenic phenomenon to inspiratory tidal volume in spontaneously breathing rats. J Appl Physiol 112: 96-105, 2012. First published October 27, 2011 doi:10.1152/japplphysiol.00690.2011Spinal cord hemisection at C2 (C2HS) severs bulbospinal inputs to ipsilateral phrenic motoneurons causing transient hemidiaphragm paralysis. The spontaneous crossed-phrenic phenomenon (sCPP) describes the spontaneous recovery of ipsilateral phrenic bursting following C2HS. We reasoned that the immediate (next breath) changes in tidal volume (VT) induced by ipsilateral phrenicotomy during spontaneous breathing would provide a quantitative measure of the contribution of the sCPP to postinjury VT. Using this approach, we tested the hypothesis that the sCPP makes more substantial contributions to VT when respiratory drive is increased. Pneumotachography was used to measure VT in anesthetized, spontaneously breathing adult male rats at intervals following C2HS. A progressive increase in VT (ml/breath) occurred over an 8 wk period following C2HS during both poikilocapnic baseline breathing and hypercapnic respiratory challenge (7% inspired CO2). The sCPP did not impact baseline breathing at 1-3 days postinjury since VT was unchanged after ipsilateral phrenicotomy. However, by 2 wk post-C2HS, baseline phrenicotomy caused a 16 Ϯ 2% decline in VT; a comparable 16 Ϯ 4% decline occurred at 8 wk. Contrary to our hypothesis, the phrenicotomy-induced declines in VT (%) during hypercapnic respiratory stimulation did not differ from the baseline response at any postinjury time point (all P Ͼ 0.11). We conclude that by 2 wk post-C2HS the sCPP makes a meaningful contribution to VT that is similar across different levels of respiratory drive. plasticity; hemisection; phrenicotomy; cervix SEVERING IPSILATERAL BULBOSPINAL inputs to phrenic motoneurons via lateral hemisection of the C2 spinal cord (C2HS) transiently paralyzes the hemidiaphragm (22,23,27,48). However, a partial return of ipsilateral phrenic motoneuron inspiratory bursting occurs over a period of weeks to months following C2HS (14,15,20,37). This response has been termed the spontaneous crossed-phrenic phenomenon (sCPP; Refs. 22,28,40). The sCPP provides an important experimental model of neuroplasticity and associated functional recovery (i.e., phrenic bursting) after spinal cord injury (22,28,40). However, the functional contribution of the sCPP to ventilation (V E) has not been definitively established. In other words, it is unclear if the relatively small amount of electrical activity that has been measured in the ipsilateral phrenic nerve after chronic C2HS is sufficient to alter inspiratory tidal volume (V T ). Thus it is unknown if C2HS-induced, spontaneous neuroplastic changes associated with the sCPP (22, 23) have a meaningful impact on the respiratory system (20).The functional impact of the sCPP has been examined to a limited extent (14,15,20). Correlations between phrenic nerve activity ...

show abstract

“…Although only some fiber types (oxidative) of the hemidiaphragm muscle become transiently hypertrophic, whereas other fiber types (glycolytic) only atrophy [24,26], the overall weight of the muscle increases to a maximum 6 to 9 days after denervation [23]. Transient hypertrophy has been suggested to occur due to passive stretching as a result of continued activity in the contralateral innervated hemidiaphragm [23][24][25], although neurotrophic influences have also been implicated [27,28]. This study shows increased Gal1 mRNA expression and immunoreactivity in both hind-limb muscle and hemidiaphragm muscle at early and late stages following denervation.…”

Section: Discussionmentioning

confidence: 99%

Galectin-1 expression in innervated and denervated skeletal muscle

Svensson¹,

Tågerud²

2009

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

Galectin-1 is a soluble carbohydrate-binding protein with a particularly high expression in skeletal muscle. Galectin-1 has been implicated in skeletal muscle development and in adult muscle regeneration, but also in the degeneration of neuronal processes and/or in peripheral nerve regeneration. Exogenously supplied oxidized galectin-1, which lacks carbohydrate-binding properties, has been shown to promote neurite outgrowth after sciatic nerve sectioning. In this study, we compared the expression of galectin-1 mRNA and immunoreactivity in innervated and denervated mouse and rat hind-limb and hemidiaphragm muscles. The results show that galectin-1 mRNA expression and immunoreactivity are up-regulated following denervation. The galectin-1 mRNA is expressed in the extrasynaptic and perisynaptic regions of the muscle, and its immunoreactivity can be detected in both regions by Western blot analysis. The results are compatible with a role for galectin-1 in facilitating reinnervation of denervated skeletal muscle.

show abstract

Respiratory muscle plasticity

Cited by 42 publications

References 241 publications

Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression

Impact of post-synaptic block of neuromuscular transmission, muscle unloading and mechanical ventilation on skeletal muscle protein and mRNA expression

Contribution of the spontaneous crossed-phrenic phenomenon to inspiratory tidal volume in spontaneously breathing rats

Galectin-1 expression in innervated and denervated skeletal muscle

Contact Info

Product

Resources

About