Respiratory outcomes of late preterm infants of mothers with early and late onset preeclampsia

Soliman, Yasser; Alshaikh, Belal; Al-Awad, Essa; Akierman, Albert; Elsharkawy, Adel; Yusuf, Kamran

doi:10.1038/s41372-019-0497-4

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…According to the present findings, neonates of preeclamptic mothers had respiratory distress 2.6 times more than neonates of non-preeclamptic mothers. Consistent with the present study, previous studies have also shown that neonates of preeclamptic mothers more commonly suffer from respiratory distress syndrome (25)(26)(27). However, conflicting findings on the effect of preeclampsia on respiratory distress syndrome have been reported (14,28).…”

Section: Discussionsupporting

confidence: 91%

Neonatal Outcomes of Severe Preeclampsia in Neonates Under 34 Weeks of Gestation

Sharami,

Kabodmehri,

Rafiei Sorouri

et al. 2023

J Kermanshah Univ Med Sci

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Background: Preterm birth is one of the common complications of preeclampsia. Neonatal outcomes seem to be more severe in the presence of preeclampsia in women with preterm birth. Objectives: This study aimed to evaluate the effect of preeclampsia on morbidity and mortality of neonates under 34 weeks of gestation at discharge. Methods: This retrospective cohort study was conducted on 311 neonates admitted to the Alzahra Tertiary Care Hospital from 2019 to 2021. Data were collected using a data extraction checklist from the medical registry. The data analysis included descriptive statistics, Chi-square, and Fisher's exact test. Multiple logistic regression was used to identify the neonatal outcomes of preeclampsia. Results: Logistic regression analysis showed that risk of cesarean section (P = 0.002, OR = 2.81), low birth weight (P = 0.018, OR = 4.04), fetal growth restriction (< 0.001, OR = 3.73), fetal distress (P = 0.005, OR = 2.60), and mortality (P = 0.019, OR = 2.89) was higher in women with severe preeclampsia after adjusting for maternal age, history of In vitro fertilization, neonate sex, and gestational age. Conclusions: Based on the results, preeclampsia increased the risk of neonatal morbidity and mortality in preterm neonates under 34 weeks. Therefore, early identification of pregnant women at risk of preeclampsia is crucial. Future studies are recommended to investigate the long-term neonatal outcomes of preeclampsia.

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Section: Discussionsupporting

confidence: 91%

Neonatal Outcomes of Severe Preeclampsia in Neonates Under 34 Weeks of Gestation

Sharami,

Kabodmehri,

Rafiei Sorouri

et al. 2023

J Kermanshah Univ Med Sci

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“…There are many papers discussing the effects of preeclampsia on infants’ birth status and its impact on the occurrence of various preterm birth complications that develop in the neonate during hospitalization in a neonatal care unit [ 10 , 11 , 12 , 13 ]. First of all, it should be remembered that compared with children born to healthy mothers, these infants more often demonstrate complications such as body weight below the 10th percentile, neutropenia, thrombocytopenia, and complications typical of preterm births including infections, newborn respiratory distress syndrome, and the associated need for hospitalization in a neonatal intensive care unit, intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, retinopathy of prematurity, or even death [ 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia

et al. 2022

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Despite many available treatments, infants born to preeclamptic mothers continue to pose a serious clinical problem. The present study focuses on the evaluation of infants born to preeclamptic mothers for the occurrence of early-onset complications and attempts to link the clinical status of such infants to the angiogenesis markers in maternal blood (sFlt-1, PlGF). The study included 77 newborns and their mothers diagnosed with preeclampsia. The infants were assessed for their perinatal outcomes, with an emphasis on adverse neonatal outcomes such us infections, RDS, PDA, NEC, IVH, ROP, or BPD during the hospitalization period. The cutoff point was established using the ROC curve for the occurrence of any adverse neonatal outcome and it was 204 for the sFlt-1/PlGF and 32 birth week with AOC 0.644 and 0.91, respectively. The newborns born to mothers with high ratios had longer hospitalization times and, generally, were more frequently diagnosed with any of the aforementioned adverse neonatal outcomes. Also, the neonates born prior to or at 32 wkGA with higher sFlt-1/PlGF ratios were statistically significantly more common to be diagnosed with any of the adverse neonatal outcomes compared to those with lower ratio born prior to or at 32 wkGA. The sFlt-1/PlGF ratio can be a useful tool in predicting short-term adverse neonatal outcomes. Infants born after a full 33 weeks gestation developed almost no severe neonatal complications. Appropriate screening and preventive healthcare for preeclampsia can contribute significantly to reducing the incidence of neonatal complications.

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Preeclampsia at term can be classified into 2 clusters with different clinical characteristics and outcomes based on angiogenic biomarkers in maternal blood

Chaiworapongsa

Romero

Gotsch

et al. 2023

American Journal of Obstetrics and Gynecology

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Respiratory outcomes of late preterm infants of mothers with early and late onset preeclampsia

Cited by 5 publications

References 44 publications

Neonatal Outcomes of Severe Preeclampsia in Neonates Under 34 Weeks of Gestation

Neonatal Outcomes of Severe Preeclampsia in Neonates Under 34 Weeks of Gestation

Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia

Preeclampsia at term can be classified into 2 clusters with different clinical characteristics and outcomes based on angiogenic biomarkers in maternal blood

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