Respiratory physiology before and after hemodialysis in chronic renal failure patients

Rd, Fairshter; Nd, Vaziri; Af, Wilson; Ar, Fugl-Meyer

doi:10.1097/00000441-197907000-00002

Cited by 16 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arterial blood gas studies indicated that chronic hypoxemia was a very common finding in this group of patients. This find ing is consistent with previous data from studies of patients with long-standing SCI [3] and with chronic renal failure [5]. The causes of arterial hypoxemia in these pa tients were probably multiple.…”

Section: Discussionsupporting

confidence: 92%

“…Patients with long-standing SCI also commonly develop chronic renal insuffi ciency [4]; this results from complications of a neuropathic bladder dysfunction including obstructive uropathy, repeated urinary tract infections, urolithiasis, and in some cases, renal amyloidosis [4], Chronic renal failure (without SCI) has been demonstrated to cause respiratory dysfunction which may worsen temporarily after hemodialysis [5]. Causes of abnormal pulmonary function in patients with chronic renal failure (CRF) in clude fluid overload and/or congestive heart failure, uremic pneumonitis and/or pleuritis, muscle weakness, and pulmonary infection, fibrosis or calcification [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Causes of abnormal pulmonary function in patients with chronic renal failure (CRF) in clude fluid overload and/or congestive heart failure, uremic pneumonitis and/or pleuritis, muscle weakness, and pulmonary infection, fibrosis or calcification [5][6][7][8][9]. Based upon the above, it is apparent that patients with CRF associated with long standing SCI have two separate processes capable of causing pulmonary abnormali ties.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Frequency and Spectrum of Pulmonary Diseases in Patients with Chronic Renal Failure Associated with Spinal Cord Injury

Rd¹,

Nd²,

S³

1983

Respiration

View full text Add to dashboard Cite

We reviewed autopsy records from 20 patients with long-standing spinal cord injury and chronic renal failure. Only 1 patient had normal pulmonary findings at autopsy. Acute and chronic pulmonary diseases were found in 16/20 and 17/20 patients, respectively. Pneumonia and fluid overload were the most common acute diseases. Interstitial and pleural fibrosis were the most common chronic diseases. However, a variety of illnesses including pulmonary amyloidosis, calcification, and arteriosclerosis were also found. Arterial blood gas studies indicated a high prevalence of hypoxemia. We concluded that significant pulmonary abnormalities are present in almost all spinal cord injury-chronic renal failure patients

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Frequency and Spectrum of Pulmonary Diseases in Patients with Chronic Renal Failure Associated with Spinal Cord Injury

Rd¹,

Nd²,

S³

1983

Respiration

View full text Add to dashboard Cite

show abstract

“…41. 42], It has also been reported that the contractile force of expiratory muscles and of the muscles involved in the handgrip test are also reduced at the end of hemodialysis with acetate [80]. The effect of acetate on the contractile force of the heart may not necessarily reduce the cardiac output because of a simultaneous fall in peripheral resistance [18, 19, 41.43.…”

Section: Functional Consequencesmentioning

confidence: 99%

Acetate Metabolism during Hemodialysis: Metabolic Considerations

et al. 1987

View full text Add to dashboard Cite

Acetate is used during regular hemodialysis to replace the bicarbonate lost during dialysis. The temporal changes of plasma bicarbonate and acetate concentrations and the critical role of acetate metabolism for the maintenance of plasma bicarbonate are described. We point out that the maximal rate of acetate oxidation in man is usually reached during dialysis, and we identify physiologic and pathologic factors that may modify this V_max. A syndrome of ‘intolerance to acetate’ has been described. This syndrome is analyzed in the light of the metabolic consequences of a rapid flux of acetate oxidation in liver and muscle cells. More specifically, the effects of rapid acetate metabolism on tissue ATP, CoA, adenosine and other ATP degradation products are presented. The possible impact of dialysis-induced depletion of carnitine on optimal acetate metabolism is discussed. The potential clinical consequences produced by these changes are presented in relation to the symptoms sometimes observed during dialysis against acetate: vasodilation, hypotension and angina pectoris. The hypoxemia induced by acetate is also briefly reviewed. Different directions are proposed for future research.

show abstract

“…The decrease of pulmonary ventilation [1][2][3] has been reported as one of the most important causes of the drop of arterial oxygen tension (PaOe) [1,10] during hemo dialysis. The elimination of CO2 across the dialyzer has been suggested as the main cause of the pulmonary hypo ventilation [2,3,11], Some authors [1,2] report that when CO2 is bubbled into a bicarbonate dialysate, less CO2 is wasted across the dialyzer and there is neither hypoventila tion nor hypoxemia.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Ventilation during Hemodialysis

Romaldini¹,

C²,

Faro³

et al. 1982

Nephron

View full text Add to dashboard Cite

During hemodialysis a decrease in pulmonary ventilation has been reported. The elimination of CO₂ across the dialyzer has been suggested as the cause of the pulmonary hypoventilation. Our purpose was to analyze the factors that could have influenced the pulmonary ventilation of 7 patients with chronic renal failure during hemodialysis, performed against an acetate dialysate with constant addition of CO₂, bubbling into the dialysis bath. In spite of the large volume of CO₂ mainly as bicarbonate, eliminated across the dialyzer there was no significant decrease of ventilation. The values of pH in the venous line were extremely low and the values of P_vCO₂ were artificially maintained around 35.0 mm Hg. Thus, the total CO₂ delivered to the lungs, but mainly the levels of pH and PCO₂ in the venous line play an important role in the control of pulmonary ventilation of these patients.

show abstract

Respiratory physiology before and after hemodialysis in chronic renal failure patients

Cited by 16 publications

References 0 publications

Frequency and Spectrum of Pulmonary Diseases in Patients with Chronic Renal Failure Associated with Spinal Cord Injury

Frequency and Spectrum of Pulmonary Diseases in Patients with Chronic Renal Failure Associated with Spinal Cord Injury

Acetate Metabolism during Hemodialysis: Metabolic Considerations

Pulmonary Ventilation during Hemodialysis

Contact Info

Product

Resources

About