Respiratory Reflexes in Response to Upper‐Airway Administration of Sevoflurane and Isoflurane in Anesthetized, Spontaneously Breathing Dogs

Mutoh, Tatsushi; Kanamaru, Arata; Tsubone, Hirokazu; Nishimura, Ryohei; Sasaki, Nobuo

doi:10.1053/jvet.2001.20329

Cited by 14 publications

(14 citation statements)

References 34 publications

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“…The adverse effects of halogenated volatile anaesthetics associated with mask induction, as experienced clinically in animals, are characterised by apnoea, breath-holding, laryngospasm, bronchoconstriction or body movements [7,9,10]. Some of these induction-related complications (e.g., struggling) also accompany mask induction in rabbits [2,4] and dogs [8].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits

Topal

Gül

2006

Ir Vet J

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The effects of sevoflurane or isoflurane on arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal CO2 tension were monitored during induction and maintenance of anaesthesia in 10 premedicated New Zealand White (NZW) rabbits.For induction, the anaesthetic agents were delivered via a face-mask. After induction was completed, an endotracheal tube was introduced for maintenance of anaesthesia for a period of 90 minutes. Changes in heart rate, respiratory rate, arterial blood gas, arterial oxyhaemoglobin saturation, blood pH and end-tidal CO2 tension were recorded. Although sevoflurane and isoflurane produce similar cardiopulmonary effects in premedicated rabbits, sevoflurane provides a smoother and faster induction because of its lower blood/gas partition coefficient. Thus sevoflurane is probably a more suitable agent than isoflurane for mask induction and maintenance. Its lower blood solubility also makes sevoflurane more satisfactory than isoflurane for maintenance of anaesthesia because it allows the anaesthetist to change the depth of anaesthesia more rapidly.

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Section: Discussionmentioning

confidence: 99%

Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits

Topal

Gül

2006

Ir Vet J

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“…Ventilatory depression in response to upper airway administration of sevoflurane is milder than that experienced with isoflurane and halothane in anaesthetized, spontaneously breathing dogs (Mutoh et al. 2001a,b). These attributes have been associated with smooth induction and rapid recovery from anaesthesia with sevoflurane in dogs.…”

Section: Introductionmentioning

confidence: 90%

Comparison of Sevoflurane with Isoflurane for Rapid Mask Induction in Midazolam and Butorphanol‐sedated Dogs

Mutoh

Kojima

Takao

et al. 2001

Journal of Veterinary Medicine Series A

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Rapid mask induction can be a useful induction technique for veterinary patients, although it is often accompanied by exaggerated excitement responses in unpremedicated animals (Mutoh et al.: Jpn. J. Vet. Anesth. Surg. 26, 109-116; J. Vet. Med. Sci. 57, 1007-1013; J. Vet. Med. Sci. 57, 1121-1124; 1995). The aim of this study was to compare sevoflurane with isoflurane for rapid mask induction in six dogs sedated by a combination of midazolam (0.1 mg/kg) and butorphanol (0.2 mg/kg). Induction with sevoflurane (5%, 2.4 minimum alveolar concentration [MAC]) in O2 resulted in shorter time to loss of the palpebral reflex, negative tail clamp response, and successful intubation than with isoflurane (3%, 2.4 MAC) in O2. There were no changes in heart rate or mean arterial blood pressure during induction with sevoflurane, whereas an increase in heart rate was observed in dogs induced with isoflurane. A decrease in respiratory rate compared with the pre-induction rate was observed during induction, and associated mild respiratory acidosis, characterized by an increase in arterial PCO2, was measured at the end of the induction period in both induction groups. None of the animals had episodes of induction-related complications. These results suggest that both sevoflurane and isoflurane produce a smooth onset of induction in midazolam and butorphanol-sedated dogs. Sevoflurane is a more suitable for rapid mask induction than isoflurane since it provides faster induction associated with a lower blood/gas partition coefficient.

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“…Similar to a previous study [9], the RR was more stable in Group D and the lower incidence of carbon dioxide retention indicated that dexmedetomidine did not impair the respiratory drive. We observed a lower RR in Group C during the procedure, which must have been associated with inhalation of a higher concentration of sevoflurane because the RR decreased as the concentration of sevoflurane increased [14]. The significantly reduced consumption of sevoflurane can reduce the environmental pollution caused by sevoflurane.…”

Section: Discussionmentioning

confidence: 69%

Efficacy of intranasal dexmedetomidine for removal of inhaled foreign bodies in children by flexible fiberoptic bronchoscopy: a randomized, double-blind, placebo-controlled clinical trial

et al. 2019

Preprint

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Background: The traditional technique for foreign body removal is rigid bronchoscopy. However, fiberoptic bronchoscopy is becoming more popular for foreign body removal. Compared with rigid bronchoscopy, fiberoptic bronchoscopy is better suited for removing foreign bodies from the distal airways and upper lobe bronchi because of the smaller diameter and greater flexibility of the bronchoscope. Dexmedetomidine, a highly selective α2 adrenergic agonist, reduces preoperative anxiety, reduces the requirement for general anesthetics, and does not induce respiratory depression. The safety and efficacy of intravenous dexmedetomidine have been confirmed in patients undergoing fiberoptic bronchoscopy. Intranasal dexmedetomidine reportedly produce satisfactory sedation in children. We hypothesized that intranasal dexmedetomidine at 1 µg·kg−1 administered 25 minutes before anesthetic induction can reduce the incidence of adverse events during fiberoptic bronchoscopy under sevoflurane inhalation general anesthesia. Methods: Forty preschool-aged children (6–48 months) with an American Society of Anesthesiologists physical status of I or II were randomly allocated to receive either intranasal dexmedetomidine at 1 µg·kg−1 or normal saline at 0.01 ml·kg−1 25 minutes before anesthetic induction. The primary outcome was the incidence of perioperative adverse events. The heart rate, respiratory rate, separation score, tolerance of the anesthetic mask, agitation score, anesthetic induction time, consumption of sevoflurane, and recovery time were also recorded. Results: The incidence of laryngospasm, breath-holding, and coughing were significantly lower in patients who received intranasal dexmedetomidine than saline (15% vs. 50%, P=0.018; 10% vs. 40%, P=0.028; and 5% vs. 30%, P=0.037, respectively). Patients who received intranasal dexmedetomidine had a lower separation score (P=0.017), more satisfactory tolerance of the anesthetic mask (P=0.027), a significantly shorter anesthetic induction time (5.75±1.4 vs. 7.75±2.5 min, P=0.004), and less consumption of sevoflurane (38.18±14.95 vs. 48.03±14.45 ml, P=0.041). The recovery time was similar in both groups, and the frequency of postoperative agitation was significantly lower in patients who received intranasal dexmedetomidine (P=0.004). Conclusions: Intranasal dexmedetomidine at 1 µg·kg−1 can reduce the incidence of laryngospasm, breath-holding, and coughing during fiberoptic bronchoscopy for foreign body removal via its sedative and analgesic effects. Moreover, intranasal dexmedetomidine can reduce postoperative agitation without a prolonged recovery time.

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Respiratory Reflexes in Response to Upper‐Airway Administration of Sevoflurane and Isoflurane in Anesthetized, Spontaneously Breathing Dogs

Abstract: Isoflurane induces greater reflex inhibition of breathing than does sevoflurane when the anesthetic is inhaled into the upper airway at concentrations used for mask induction.

Cited by 14 publications

References 34 publications

Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits

Comparison of the arterial blood gas, arterial oxyhaemoglobin saturation and end-tidal carbon dioxide tension during sevoflurane or isoflurane anaesthesia in rabbits

Comparison of Sevoflurane with Isoflurane for Rapid Mask Induction in Midazolam and Butorphanol‐sedated Dogs

Efficacy of intranasal dexmedetomidine for removal of inhaled foreign bodies in children by flexible fiberoptic bronchoscopy: a randomized, double-blind, placebo-controlled clinical trial

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