Respiratory resistance measured by an airflow perturbation device

Lausted, Christopher; Johnson, Arthur T.

doi:10.1088/0967-3334/20/1/002

Cited by 34 publications

(34 citation statements)

References 17 publications

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“…It is the measurement of clinical and physiological interest, and is useful for evaluating the respiratory effects of bronchodilatory or bronchoconstrictive drugs. Increased resistance is usually due to narrowing and collapse of airways and clinically related to an assortment of respiratory diseases such as asthma and bronchitis (Lausted and Johnson, 1999;Ruppel, 2004).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary effects and disposition of luteolin and Artemisia afra extracts in isolated perfused lungs

Mjiqiza

Syce

Obikeze

2013

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Artemisia afra (Asteraceae) is a traditional medicinal plant frequently used in steam inhalation form to treat respiratory conditions. Aim of the study: Quantify luteolin content in Artemisia afra dried crude and aqueous extract. Evaluate the pulmonary effects of Artemisia afra steam inhalation, nebulized Artemisia afra extract and luteolin in isolated perfused lungs (IPL). Evaluate the pulmonary disposition of intravenously administered luteolin. Materials and methods: HPLC was used to quantify luteolin in Artemisia afra extracts. A modified version of the IPL was used to determine the effects of Artemisia afra steam inhalation, nebulized luteolin, and nebulized aqueous leaf extract on lung function, as well as the pulmonary disposition of IV luteolin. Results: Artemisia afra extract contained significantly higher luteolin levels than the crude dried leaves. Inhaled Artemisia afra steam, and nebulized luteolin, and Artemisia afra extract and IV luteolin produced significant dosedependent improvements in lung function, with nebulized Artemisia afra producing the greatest improvements. Nebulisation with Artemisia afra extract yielded higher quantities of luteolin than luteolin nebulisation. Conclusion: Results verify the traditional use of inhalation of Artemisia afra steam, although nebulized luteolin and aqueous extract are better alternatives. Luteolin significantly contributes to the broncho-dilatory effects of Artemisia afra.

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Section: Discussionmentioning

confidence: 99%

Pulmonary effects and disposition of luteolin and Artemisia afra extracts in isolated perfused lungs

Mjiqiza

Syce

Obikeze

2013

Journal of Ethnopharmacology

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“…Resistance measurement is useful in evaluating the severity of respiratory diseases, respiratory effects of bronchoconstrictive and bronchodilatory drugs, as well as airborne contaminants and naturally occurring particulates [1] [2].…”

Section: Introductionmentioning

confidence: 99%

“…The airflow perturbation device (APD) is a medical instrument developed for noninvasive measurement of respiratory resistance that includes airways, lung tissue, and chest wall components [1] [2] [3] [4]. It is quite simple to use, and has advantages for measurements on small children, unconscious or uncooperative patients, in the home, and on animals.…”

Section: Introductionmentioning

confidence: 99%

“…Data collected by the APD are analyzed in real time and displayed as averages of approximately 100 perturbations. APD measured resistances have been correlated to resistances measured by spirometry [6], body plethysmograph [1] [6], esophageal balloon [7] [8], and impulse oscillometry [9], although the first three of these do not measure all of the components of respiratory resistance. Population averages of respiratory resistances as measured by the APD have been determined for thousands of subjects [10].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Induced Anxiety on Respiratory Resistance Using Virtual Reality Simulation

Bohensky¹,

Johnson²,

Vossoughi³

2017

OJRD

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Background: The purpose of this research was to identify significant changes to respiratory resistance resulting from anxiety inducing simulations presented through the medium of virtual reality (VR) goggles. The tested hypothesis was that a virtual reality simulation would produce anxiety in the wearer, and, with it, a statistically significant change in subject respiratory resistance. It was also suggested that there may be a significant difference in the levels of respiratory resistance responses of males and females. The Oculus Rift DK2 VR goggles with video software designed for the Rift were used to induce anxiety in the wearers. Methods: Respiratory resistances in both inhalation and exhalation directions were measured with the Airflow Perturbation Device (APD), a medical instrument used noninvasively. Two groups of subjects were tested: the test group watched a simulation deemed to be anxiety inducing, and the Control group watched a simulation determined to be non-anxiety inducing. Anxiety levels and respiratory resistance were measured before and during the simulation with two anxiety measures, the State Trait Anxiety Inventory (STAI) and the Subjective Units of Distress Scale (SUDS). Results: Statistically significant increases in anxiety level and respiratory resistance were found in the Test group, but no significant differences in anxiety and respiratory resistance levels were found in the control group. Anxiety affected both breathing phases similarly. For the gender hypothesis, we found that one of the tests used to measure anxiety, (the SUDS difference) was statistically significant, while the other test and the difference in respiratory resistance were not statistically significant. Conclusion: Results from this experiment show that anxiety level can be a significant contributor to the physiological measurement of respiratory resistance, and this can have implications for pulmonary function test environments and the psychological conditions of the patients being tested.

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“…The wheel modifies, or perturbs, flow rates and mouth pressures, the amounts of which depend on respiratory resistance and device resistance [12] [13]. Device resistance is measured, so respiratory resistance can be obtained.…”

Section: Introductionmentioning

confidence: 99%

Testing Low Doses of Caffeine on Respiratory Resistance Using the Airflow Perturbation Device

Montgomery¹,

Luk²,

Johnson³

et al. 2017

OJRD

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Research reports on pulmonary function measurements often mention caffeine abstinence as a condition for testing subjects. Yet, the effects of caffeine on respiration are not well documented. This study was intended to investigate the physiological effects of caffeine on respiratory resistance measurements and the necessity of caffeine avoidance in such testing. Thirty-one subjects were administered caffeine in pill form for dosages in the range of 3 -4.5 mg/kg body weight. Respiratory resistance was measured with the Airflow Perturbation Device every 15 minutes after caffeine ingestion until a full hour of elapsed time. No changes were noted in inhalation, exhalation, and average respiratory resistances during the times of measurements. The conclusion is that for low dosages of caffeine, respiratory resistance measurements are not affected by caffeine ingestion prior to testing.

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Respiratory resistance measured by an airflow perturbation device

Cited by 34 publications

References 17 publications

Pulmonary effects and disposition of luteolin and Artemisia afra extracts in isolated perfused lungs

Pulmonary effects and disposition of luteolin and Artemisia afra extracts in isolated perfused lungs

Effect of Induced Anxiety on Respiratory Resistance Using Virtual Reality Simulation

Testing Low Doses of Caffeine on Respiratory Resistance Using the Airflow Perturbation Device

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