Respiratory stimulant effects of adenosine in man after caffeine and enprofylline.

Smits, Paul; Schouten, Jan S.A.G.; Thien, Theo

doi:10.1111/j.1365-2125.1987.tb03251.x

Cited by 19 publications

(12 citation statements)

References 11 publications

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“…This paper confirms the finding that adenosine is a stimulator of minute ventilation in humans [2,4,6,12] and that this effect is antagonized by theophylline [10,11]. We show that the ventilatory stimulating effect was not antagonized by metoprolol, atropine or naloxone but was enhanced after dipyridamole treatment.…”

Section: Discussionsupporting

confidence: 91%

Adenosine receptor mediated stimulation of ventilation in man

Jonzon¹,

Sylvén

Beermann

et al. 1989

Eur J Clin Investigation

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Abstract. We wanted to examine how adenosine stimulates ventilation in man. Bolus doses of adenosine were given i.v. in an antebrachial vein in multiples of 2.65 mg. The minute ventilation was increased by adenosine 5.3 to 15.9 mg (median values) from control 12.6 ± 1.9 1 min‐1 to 42.5 ± 4.7 1 min‐1 in a dose‐dependent manner. The adenosine receptor antagonist theophylline, 58.3 ± 3.3 (mean±SEM) µniol 1‐1 plasma, inhibited the response by approximately 25%. Dipyridamole 10 mg, an adenosine uptake blocker, enhanced the effect of adenosine by approximately 60%. The ventilation was not affected by metoprolol, atropine, naloxone or cromolyn sodium but was attenuated by hyperventilation. The respiratory stimulation started before chest pain and cardiovascular effects such as AV‐block were encountered. It is concluded that this respiratory stimulation shows characteristics of adenosine receptor mediated responses but the location of such adenosine receptors is uncertain. The findings are compatible with a stimulatory or facilitating effect of adenosine on afferent pathways.

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Section: Discussionsupporting

confidence: 91%

Adenosine receptor mediated stimulation of ventilation in man

Jonzon¹,

Sylvén

Beermann

et al. 1989

Eur J Clin Investigation

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“…At the same time, venous PCO 2 fell and pH rose after ADN infusion. 31 ADN infusion at rates of 6.1 mg/min and up to 8.5 mg/min caused a significant increase in tidal volume, with an associated significant fall in ET-CO 2 . Mean inspiratory flow rate increased and expiratory duration decreased during ADN infusion, but there was no change in inspiratory duration.…”

Section: Discussionmentioning

confidence: 90%

Effect of Adenosine on Cerebral Blood Flow Velocity

Zanferrari¹,

Razumovsky²,

Lavados³

et al. 2001

Journal of Neuroimaging

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“…But as mentioned before it is known that exogenous adenosine stimulates ventilation by activating the carotid bodies. [8][9][10]30,32,34 Considering the results of this study it seems possible that endogenous adenosine influences the HVR and the ventilatory drive. This reaction could help the organism to fight against hypoxia as adenosine is released within tissues under hypoxic conditions, because of increased tissue-ATP-depletion as a consequence of reduced oxygen delivery.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 On the other hand, binding to the A2-receptor at the carotid bodies causes an increase of respiration. [8][9][10] The physiological concentration of adenosine in blood plasma shows great interindividual differences, but normally the concentration is in the nanomolar range. 1,3,11 We examined to what extent plasma adenosine concentration in peripheral venous blood correlates with spirometry data.…”

mentioning

confidence: 99%

Plasma Adenosine during Investigation of Hypoxic Ventilatory Response

et al. 2004

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Adenosine, an endogenous nucleoside, is released by hypoxic tissue, causes vasodilation, and influences ventilation. Its effects are mediated by P1-purinoceptors. We examined to what extent the plasma adenosine concentration in the peripheral venous blood correlates with hypoxic ventilatory response (HVR) and ventilatory drive P0.1 to find out whether endogenously formed adenosine has an influence on the individual ventilatory drive under hypoxic conditions. While investigating the HVR of 14 healthy subjects, the ventilatory drive P0.1 was measured with the shutter of a spirometer. Determination of the ventilatory drive P0.1(RA) started under room air conditions (21% O (2)) and then inspiratory gas was changed to a hypoxic mixture of 10% O (2) in N (2) to determine P0.1(Hyp). At the time of the P0.1 measurements, two blood samples were taken to determine the adenosine concentrations. After removal of cellular components and proteins, samples were analyzed by high-pressure liquid chromatography (HPLC). Both adenosine concentrations in plasma under room air (r = 0.59, p < 0.05) and adenosine concentrations under hypoxia (r = 0.75, p < 0.01) correlated significantly with the ventilatory drive P0.1. In addition, plasma adenosine concentrations during hypoxic conditions showed a significant correlation with HVR on the 0.01 level (r = 0.71, p < 0.01). The results indicate a possible role of endogenous adenosine in the regulation of breathing in humans. We assume that endogenous adenosine influences the HVR and the ventilatory drive, probably by modulating the carotid body chemoreceptor response to hypoxia.

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Respiratory stimulant effects of adenosine in man after caffeine and enprofylline.

Cited by 19 publications

References 11 publications

Adenosine receptor mediated stimulation of ventilation in man

Adenosine receptor mediated stimulation of ventilation in man

Effect of Adenosine on Cerebral Blood Flow Velocity

Plasma Adenosine during Investigation of Hypoxic Ventilatory Response

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