Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study

Toelle, Brett G.; Xuan, Wei; Bird, T.; Abramson, Michael J.; Atkinson, David; Burton, Deborah; James, Alan; Jenkins, Christine; Johns, DP; Maguire, Graeme; Musk, Arthur W.; Walters, E. Haydn; Wood‐Baker, Richard; Hunter, Michael; Graham, Bruce; Southwell, Phillipa; Vollmer, William M.; Buist, A. Sonia; Marks, Guy B.

doi:10.5694/mja11.11640

Cited by 105 publications

(166 citation statements)

References 18 publications

Supporting

Mentioning

159

Contrasting

Order By: Relevance

“…2 In Australia, the prevalence of COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 stage II or higher) is reported as 7.5% among people aged >40 years and 29.2% among those aged >75 years. 4 Pulmonary rehabilitation (PR) is a programme of structured supervised exercise, education, and psychosocial support which is recommended by international guidelines in the management of people with COPD. 3 There is strong evidence that PR improves exercise tolerance, reduces anxiety, and improves symptoms in people with moderate to severe COPD.…”

Section: Introductionmentioning

confidence: 99%

Barriers to, and facilitators for, referral to pulmonary rehabilitation in COPD patients from the perspective of Australian general practitioners: a qualitative study

Johnston

Young

Grimmer

et al. 2013

Primary Care Respiratory Journal

107

111

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Barriers to, and facilitators for, referral to pulmonary rehabilitation in COPD patients from the perspective of Australian general practitioners: a qualitative study

Johnston

Young

Grimmer

et al. 2013

Primary Care Respiratory Journal

107

111

View full text Add to dashboard Cite

show abstract

“…The prevalence of chronic obstructive pulmonary disease (COPD) has increased dramatically in Western populations during the last few decades [1,2], and has become a major challenge to public health and healthcare systems due to frequent hospitalisations, severe comorbidities and a high mortality rate [2,3]. Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common disease with complications such as the post-thrombotic syndrome, chronic thromboembolic pulmonary hypertension and death [4,5].…”

Section: Introductionmentioning

confidence: 99%

COPD and risk of venous thromboembolism and mortality in a general population

et al. 2015

View full text Add to dashboard Cite

The relationship between chronic obstructive pulmonary disease (COPD) and risk of venous thromboembolism (VTE) has been scarcely studied in the general population. We aimed to investigate the association between COPD and risk of VTE and mortality in a population-based cohort.Spirometry was conducted in 8646 males and females, participating in the fifth (2001-02) and sixth (2007-08) surveys of the Tromsø Study. Incident VTE events during follow-up were registered from the date of inclusion to December 31, 2011. Cox-regression models with COPD stages and confounders as time varying covariates were used to calculate hazard ratios with 95% confidence intervals for VTE and all-cause mortality.During a median follow-up of 6.2 years, 215 subjects developed VTE. Subjects with COPD stage III/IV had a two-fold higher risk of secondary VTE compared to subjects with normal airflow (HR 2.05, 95% CI 1.02-4.10). COPD patients, particularly those with stage III/IV disease, with VTE had a higher mortality rate than COPD patients without VTE (50.2% versus 5.6% per year).Our findings suggest that patients with severe COPD may have increased risk of secondary VTE, and that COPD patients with VTE have a higher mortality rate than COPD patients without VTE. @ERSpublications Patients with severe COPD may have increased risk of VTE: VTE is associated with a worse prognosis in COPD patients

show abstract

“…Potentially this could have increased the proportion of COPD in the final population as higher CDQ scores reflect higher COPD prevalence and COPD diagnoses increase with age. 4 The proportion of subjects excluded from the statistical analysis (i.e. 35%) is almost double the cases excluded from the CDQ validation study by Kotz et al 20 (18%) and substantially higher than the Greek and Australian external validity studies as well as the original study (9%).…”

Section: Strengths and Limitation Of This Studymentioning

confidence: 97%

Validation of the COPD Diagnostic Questionnaire in an Australian general practice cohort: a cross-sectional study

Stanley

Hasan²,

Crockett

et al. 2014

Primary Care Respiratory Journal

View full text Add to dashboard Cite

Background: The gold standard for the diagnosis of chronic obstructive pulmonary disease (COPD) is spirometry, but there are barriers to its use in primary care. Aims: To externally validate the COPD Diagnostic Questionnaire (CDQ) as a diagnostic tool in patients at increased risk in Australian general practice and to compare its performance with other CDQ validation studies. Methods: Patients were recruited from 36 general practices in Sydney, Australia. Former or current smokers aged 40–85 years with no prior COPD diagnosis were invited to a case-finding appointment with the practice nurse. The CDQ was collected and pre- and postbronchodilator spirometry was performed. Cases for whom complete CDQ data were present and the spirometry met quality standards were analysed. Results: Of 1,631 patients who attended case-finding recruitment, 1,054 (65%) could be analysed. Spirometry showed 13% had COPD. The ability of the CDQ to discriminate between patients with and without COPD was fair, represented by the area under the receiver operating characteristic curve of 0.713. With a CDQ cut-off point value of 16.5 the sensitivity was 80% and specificity 47% and, at a cut-off point value of 19.5, the sensitivity was 63% and specificity 70%. Conclusions: The CDQ did not discriminate between patients with and without COPD accurately enough to use as a diagnostic tool in patients at increased risk of COPD in Australian general practice. Further research is needed on the value of the CDQ as a tool for selecting patients for spirometry.

show abstract

Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study

Abstract: Symptoms and spirometric evidence of COPD are common among people aged 40 years or older and increase with age. Further research is needed to better understand the diagnosis and management of COPD in Australia, along with continuing efforts to prevent the disease.

Cited by 105 publications

References 18 publications

Barriers to, and facilitators for, referral to pulmonary rehabilitation in COPD patients from the perspective of Australian general practitioners: a qualitative study

Barriers to, and facilitators for, referral to pulmonary rehabilitation in COPD patients from the perspective of Australian general practitioners: a qualitative study

COPD and risk of venous thromboembolism and mortality in a general population

Validation of the COPD Diagnostic Questionnaire in an Australian general practice cohort: a cross-sectional study

Contact Info

Product

Resources

About