Respiratory syncytial virus and palivizumab prophylaxis in the COVID-19 era

Taylor, Richard

doi:10.1503/cmaj.78240

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…In those regions of Russia where RSV circulates for extended periods throughout the year, PVZ prophylaxis might need to be administered longer if one wants to ensure full protection. Considering, however, that PVZ is an expensive drug [ 32 ], the question of regional RSV seasonality and the delivery of PVZ prophylaxis needs to be carefully considered. Since 2015 in Russia, PVZ has been included in the list of vital medicines for infants in the first year of age at risk for severe RSV infection.…”

Section: Discussionmentioning

confidence: 99%

A comparative analysis of the epidemiology of influenza and respiratory syncytial virus in Russia, 2013/14 to 2018/19

et al. 2022

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Background Influenza and respiratory syncytial virus (RSV) are among the leading causes of lower respiratory tract infections worldwide. We conducted a comparative analysis of the age distribution and spatiotemporal epidemiology of influenza and RSV in Russia using sentinel surveillance data from 2013-14 to 2018-19 in six cities located in the western, central, and eastern regions of the country. Methods We calculated the positivity rate for influenza and RSV (by month, season, and overall) in each city, separately for patients seen at the primary and secondary care level (out-patients medical centres housing GP practices and infectious diseases hospitals, respectively). We compared the age distribution of patients infected with the different influenza virus (sub)types and RSV. Results A total of 17 551 respiratory specimens were included: the overall positivity rate was 13.5% for influenza and 4.4% for RSV. The A(H1N1)pdm09, A(H3N2) and B virus (sub)types caused 31.3%, 44.0% and, respectively, 24.7% of all influenza cases. The median age was older among influenza (15 years) than among RSV patients (3 years); differences across influenza virus (sub)types were seen only at the primary care level, with influenza A(H3N2) patients being significantly older than A(H1N1)pdm09 or B influenza patients. The timing of influenza epidemics was similar across cities, with the peak typically occurring in February or March. In contrast, the typical peak timing of RSV epidemics varied largely across cities, and the virus was often detected also in spring and summer months (unlike influenza). Conclusions Influenza and RSV epidemiology differed in many regards in Russia, especially in the timing of epidemics and the age distribution of infected subjects. Health policies aimed at containing the burden of diseases of viral respiratory infections in Russia should take these findings into account.

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Section: Discussionmentioning

confidence: 99%