Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia

Resch, Bernhard; Liziczai, Krisztina; Reiterer, F; Freidl, Thomas; Haim, Michaela; Urlesberger, Berndt

doi:10.1016/j.pedneo.2017.08.005

Cited by 10 publications

(22 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since the affected lung will be compressed by internal organs which occupy space during intrauterine development of CDH children, its development will be impaired to varying degrees; further, since the healthy lung is affected by mediastinal movement, its respiratory function will also be impaired to some extent [19, 20]. Previously publications have reported that pulmonary dysplasia on the affected side mainly manifests in different degrees of alveolar surface area reduction, the reduced number of bronchial trees, the decrease in pulmonary vascular inner diameter, and thickening of the median membrane, all of which result in pulmonary hypertension [21, 22].…”

Section: Discussionmentioning

confidence: 99%

A comparative study of thoracoscopic and open surgery of congenital diaphragmatic hernia in neonates

Qin

Ren

2019

J Cardiothorac Surg

View full text Add to dashboard Cite

Background An increasing number of hospitals have carried out neonatal thoracoscopic assisted repair of congenital diaphragmatic hernia (CDH). Methods The 26 cases received thoracoscopic-assisted repair (observation group) and 44 cases open repair (control group). General anesthesia was performed with endotracheal intubation using a trachea cannula without cuff. The general preoperative data, intraoperative hemodynamic parameters, intraoperative surgical conditions, postoperative complications, postoperative recovery condition, postoperative survival rate and recurrence rate were recorded. Results The intraoperative mean arterial pressure and heart rate at each time point in observation group were more stable and effective than those in control group (all P < 0.001). The number of manual ventilation, SpO 2 < 90% and hypercapnia cases were significantly lower than those in control group (all P < 0.05). Intraoperative bleeding, incision length and operation duration were significantly lower in observation group compared with control group (all P < 0.001). No significant differences were seen between the two groups in postoperative complications including pulmonary infection, incision infection, pulmonary hypertension, hemorrhage, and scleredema (all P > 0.05). The duration of postoperative mechanical ventilation, antibiotic use and hospitalization in observation group was significantly shorter than those in control group (all P < 0.05). There was no significant difference in postoperative survival rate and recurrence rate between the two groups (both P > 0.05). Conclusion The intraoperative hemodynamic parameters of CDH repair under thoracoscopy were more stable, the duration of postoperative mechanical ventilation, antibiotic use and hospitalization were shortened, and the therapeutic effect was better.

show abstract

Section: Discussionmentioning

confidence: 99%

A comparative study of thoracoscopic and open surgery of congenital diaphragmatic hernia in neonates

Qin

Ren

2019

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…2 The efficacy of palivizumab prophylaxis in other high-risk populations, such as those with pulmonary abnormality or neuromuscular disease, is of concern. Resch et al 1 have reported a trend of reduction in the number of RSV-associated hospitalizations in infants with CDH receiving palivizumab prophylaxis, although the reduction was not statistically significant. However, this study has reported about only two proven RSV infections.…”

mentioning

confidence: 98%

“…We read with great interest the article authored by Resch et al 1 [1] that reported a moderate risk of respiratory syncytial virus (RSV)-associated hospitalizations in infants with congenital diaphragmatic hernia (CDH) and that palivizumab prophylaxis resulted in a nonsignificant reduction in the number of RSV-associated hospitalizations. Although this is an important finding having clinical implications, this study has some limitations, and we would like to make some comments on this article.…”

mentioning

confidence: 99%

“…The majority of RSV-associated hospitalizations were actually hypothetical cases, without RSV test being performed. Resch et al 1 have speculated that 70% of severe lower respiratory tract admissions were attributed to RSV infection. This proportion was inferred from the literature reporting that RSV accounts for 50%e80% of all hospitalizations for bronchiolitis during seasonal epidemics.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The effect of palivizumab prophylaxis on respiratory syncytial virus-associated hospitalizations in infants with congenital diaphragmatic hernia

Shao

2018

Pediatrics & Neonatology

View full text Add to dashboard Cite

“…However, prophylaxis may be considered for children <2 years of age who are on home oxygen, have had a prolonged hospitalization for severe pulmonary disease, or are severely immunocompromised. While limited evidence suggests that palivizumab may be beneficial in reducing the severity of RSV illness and RSV-related hospitalization (RSVH) [14, 17], the impact of RSV prophylaxis in CDH in early infancy remains unclear. Therefore, the primary objective of this article was to determine the risk of respiratory illness–related hospitalization (RIH) and RSVH in infants with CDH who received RSV prophylaxis with palivizumab during the RSV season compared to infants prophylaxed for standard indications (SIs) and those who received prophylaxis but were considered not at increased risk (NR).…”

mentioning

confidence: 99%

Respiratory Syncytial Virus Prophylaxis in Infants With Congenital Diaphragmatic Hernia in the Canadian Respiratory Syncytial Virus Evaluation Study of Palivizumab, 2005–2017

Kim

Saleem

Paes

et al. 2018

Clinical Infectious Diseases

View full text Add to dashboard Cite

Background Infants with congenital diaphragmatic hernia (CDH) are at an increased risk of respiratory morbidity from recurrent respiratory tract infections including those from respiratory syncytial virus (RSV). Prospective studies on RSV prophylaxis in CDH infants are limited. We determined the risk of respiratory illness– and RSV-related hospitalizations (RIH and RSVH, respectively) among infants prophylaxed for CDH, standard indications (SIs) and those without increased risk (NR). Methods The prospective Canadian Respiratory Syncytial Virus Evaluation Study of Palivizumab (CARESS) registry was searched for infants who received palivizumab during 12 RSV seasons (2005–2017) in Canada. Cox proportional hazards analyses were conducted to compare RIH and RSVH risks across the groups adjusted for potential confounders. Results In total, 21 107 infants (201 CDH, 389 NR, and 20 517 SI) were included. RIH incidences were 10.0% (CDH), 2.1% (NR), and 6.2% (SI). CDH patients had a significantly higher RIH hazard compared with NR (hazard ratio [HR], 3.6 [95% confidence interval {CI}, 1.5–8.8]; P = .005) but not SI (HR, 1.2 [95% CI, .8–2.0]; P = .379). RSVH incidences were 0.6%, 0.3%, and 1.5% for CDH, NR, and SI, respectively. RSVH risk was similar across groups (SI: HR, 0.0, P = .922; NR: HR, 0.0, P = .934). Conclusions CDH infants had a 3-fold increased risk of RIH compared to NR but not SI infants. RSVH risk was similar with low RSVH incidences across all groups, implying that CDH infants may benefit from palivizumab during the RSV season, similar to other high-risk groups. Clinical Trials Registration NCT00420966.

show abstract

Respiratory syncytial virus associated hospitalizations in children with congenital diaphragmatic hernia

Abstract: We found a moderate rate of proven RSV hospitalizations in infants with CDH, and palivizumab prophylaxis led to a non-significant reduction of proven and hypothesized RSV hospitalizations.

Cited by 10 publications

References 17 publications

A comparative study of thoracoscopic and open surgery of congenital diaphragmatic hernia in neonates

A comparative study of thoracoscopic and open surgery of congenital diaphragmatic hernia in neonates

The effect of palivizumab prophylaxis on respiratory syncytial virus-associated hospitalizations in infants with congenital diaphragmatic hernia

Respiratory Syncytial Virus Prophylaxis in Infants With Congenital Diaphragmatic Hernia in the Canadian Respiratory Syncytial Virus Evaluation Study of Palivizumab, 2005–2017

Contact Info

Product

Resources

About