Respiratory Syncytial Virus Bronchiolitis and Bronchial Asthma (Preprint)

Abstract

BACKGROUND Infectious bronchiolitis caused by respiratory capillary syncytial bronchial virus. This disease is an infectious disease of the lower respiratory tract caused by obstruction of respiratory capillary syncytial bronchial virus infection, causing respiratory obstruction and shortness of breath, difficulty breathing, and hypoxia. There are currently no reliable indicators to assess the prognosis of respiratory syncytial virus bronchiolitis and the risk of secondary bronchial asthma. In order to explore the correlation between respiratory syncytial virus bronchiolitis and bronchial asthma, experiments and mathematical statistics were used. The controlled experiment used in this paper shows that the incidence of bronchiolitis is about 20% -30% in the first year after birth and about 10% -20% in the second year. 30% -50%, this article also compared three kinds of respiratory viruses, respiratory syncytial virus infection rate is the highest, 61.4%. The results of this study show that respiratory syncytial virus infection is the main pathogen that induces asthma, especially bronchiolitis, so it is very important for patients to diagnose early and correctly understand the causes of asthma. OBJECTIVE In order to explore the correlation between respiratory syncytial virus bronchiolitis and bronchial asthma, experiments and mathematical statistics were used METHODS Respiratory Syncytial Virus Capillary Bronchitis RESULTS the comparison results are similar. Then, the RSV-positive bronchiolitis specimens (96 cases) were amplified and sequenced for the entire G protein gene sequence, and 40 cases of the complete G protein sequence (35 cases of subtype A and 5 cases of subtype B) were successfully obtained. The analysis results showed that 6 A subtype genotypes (NAl, NA2, NA3, NA4, GA5, ON1) and 5 B subtype genotypes (BA3, BA7, BA9, BA10, CB1) were detected. The percentage of RNA types in the exosomes of simulated and RSV infected A549 cells is shown in Table 2. Among subtype A, NA1 genotype (55.1%) and ON1 genotype (39.1%) were the dominant genotypes, and subtype B had BA9 (90.6%) as the absolute dominant genotype. CONCLUSIONS At present, there is a certain understanding of the relationship between respiratory syncytial virus bronchiolitis and bronchial asthma, and severe bronchiolitis and pneumonia can occur after infants with respiratory syncytial virus infection. It has a certain relationship with childhood asthma. The symptoms of the two patients ranged from severe to severe. In severe cases, breathing difficulties developed rapidly, and even life-threatening. Some respiratory syncytial virus bronchiolitis may be secondary to bronchial asthma, causing social and family economic burden. Studying the pathogenesis of respiratory syncytial virus (RSV) infection is helpful for understanding the disease. In particular, the relationship between early wheezing, the occurrence, development and prognosis of asthma has been a key direction for assisting patients in practical application. In order to explore the correlation between respiratory syncytial virus bronchiolitis and bronchial asthma, experimental methods were used to conduct controlled trials and data statistics on patients, objectively reflecting the relationship between respiratory syncytial virus bronchiolitis and bronchial asthma. This article uses a control experiment and other methods. The experiment shows that the incidence of bronchiolitis is about 20% -30% in the first year after birth and about 10% -20% in the second year. The incidence of acute wheezing disease in preschool children The incidence rate can be as high as 30% -50%, the virus positive rate is 51%, and the positive rate of M. pneumoniae is about 32%. The positive rate of bacteria detected was 25%. The virus detection rate is higher than that of Mycoplasma pneumoniae and bacteria. After statistical processing, the difference is significant. In addition, through mathematical statistics and logical analysis, it was found that IFN-γ / IL-4 and IL-10 / IL-17 in children with respiratory syncytial virus bronchiolitis and asthma were significantly reduced, while TGF- β / IL-17 was significantly lower than that of children with non-RSV pneumonia and healthy control children (P <0.05). It indicates that after RSV infection, Th2 cells and its specific cytokine IL-4 expression may be up-regulated in the body for a long time, thereby promoting the occurrence of subsequent asthma. It suggests that RSV bronchiolitis and the severity of the disease are closely related to the occurrence of asthma in the later period. The results of this study show that respiratory syncytial virus infection is the main pathogen that induces asthma, especially bronchiolitis, so it is very important for patients to diagnose early and correctly understand the causes of asthma.