Respiratory syncytial virus infection among adults during influenza season: A frequently overlooked diagnosis

Martínez‐Sanz, Javier; Reyzábal, Sergio Gilaberte; Hernando, J. Salillas; Gómez, María Rosa Lago; Rodríguez-Zurita, María Elena; Torralba, Miguel

doi:10.1002/jmv.25462

Cited by 12 publications

(17 citation statements)

References 22 publications

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“…The prescription rate was lowest in the influenza A H3 group, at 17% ( P = .036), and highest in the RSV group, at 28% ( P = .004). This result is in line with findings from studies from Spain, which found empirical antimicrobial therapy significantly more frequent in patients diagnosed with RSV than influenza during hospital stay 28,29 …”

Section: Discussionsupporting

confidence: 90%

“…This result is in line with findings from studies from Spain, which found empirical antimicrobial therapy significantly more frequent in patients diagnosed with RSV than influenza during hospital stay. 28 , 29 …”

Section: Discussionmentioning

confidence: 99%

“…Although there is an overlap in symptoms, several studies show that the presence of rhinorrhea and wheezing is suggestive of RSV, whereas fever above 38°C more frequently occurs with influenza infections. 28 , 30 , 31 , 32 , 33 , 34 , 35 …”

Section: Discussionmentioning

confidence: 99%

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Etiology of viral respiratory tract infections in hospitalized adults, and evidence of the high frequency of prehospitalization antibiotic treatment in Norway

Debes

Haug

Blasio

et al. 2021

Health Science Reports

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Background and aims Respiratory tract infections (RTIs) cause considerable morbidity and mortality in all age groups, but the epidemiology and role of several of the viral RTIs in the adult and elderly patients are still unclear, as is the extent of prehospitalization antibacterial drug use in this population. Methods We conducted a three‐year (2015‐2018) observational study of viral RTIs in hospitalized patients in a 500‐bed hospital in Southeastern Norway, including all patients ≥18 years with RTI symptoms where one of the following viral agents was detected in a respiratory specimen (Seegene Allplex): Influenza A/B, RSV A/B, human metapneumovirus (hMPV), adenovirus and parainfluenza virus 1‐4. Viral findings, demographical data, and information on prehospital antibiotic prescriptions were recorded. Results In 1182 patients 1222 viral infection events occurred. The mean patient age was 69.6 years, and 53% were females. Influenza virus A/B (63%), RSV A/B (15%) and hMPV (13%) were the most common agents detected. The proportional burden of influenza A H1 was found to be relatively high (65%) in the age groups <69 years, compared to older patients ( P = .001, chi‐square). As many as 20% of the patients had been treated with antibiotics prior to admission, with the lowest rate for influenza A H3 group at 17% ( P = .036, chi‐square), and highest for the RSV group at 28% ( P = .004, chi‐square). Oseltamivir was prescribed prior to hospitalization in only 3 cases (0.2%). Conclusions We found a high rate of prehospital antibiotic prescription in adults hospitalized with viral RTIs, warranting better stewardship programs to tackle the increasing antibiotic resistance problem.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Etiology of viral respiratory tract infections in hospitalized adults, and evidence of the high frequency of prehospitalization antibiotic treatment in Norway

Debes

Haug

Blasio

et al. 2021

Health Science Reports

View full text Add to dashboard Cite

show abstract

“…A recent study assessing laboratory-confirmed hospitalised RSV cases in the USA found that only 44% had RSV-specific International Classification of Diseases discharge codes (in the first nine positions), suggesting that administrative data underestimate adult RSV-related hospitalisations 8. Furthermore, studies suggest that antibiotic use, morbidity and mortality are higher among RSV-positive than influenza-positive adult hospitalised patients9–11 and RSV patients are more likely to need hospital re-admission 12…”

Section: Introductionmentioning

confidence: 99%

Molecular point-of-care testing for influenza A/B and respiratory syncytial virus: comparison of workflow parameters for the ID Now and cobas Liat systems

et al. 2019

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AimsPoint-of-care (POC) tests for influenza and respiratory syncytial virus (RSV) offer the potential to improve patient management and antimicrobial stewardship. Studies have focused on performance; however, no workflow assessments have been published comparing POC molecular tests. This study compared the Liat and ID Now systems workflow, to assist end-users in selecting an influenza and/or RSV POC test.MethodsStaffing, walk-away and turnaround time (TAT) of the Liat and ID Now systems were determined using 40 nasopharyngeal samples, positive for influenza or RSV. The ID Now system requires separate tests for influenza and RSV, so parallel (two instruments) and sequential (one instrument) workflows were evaluated.ResultsThe ID Now ranged 4.1–6.2 min for staffing, 1.9–10.9 min for walk-away and 6.4–15.8 min for TAT per result. The Liat ranged 1.1–1.8 min for staffing, 20.0–20.5 min for walk-away and 21.3–22.0 min for TAT. Mean walk-away time comprised 38.0% (influenza positive) and 68.1% (influenza negative) of TAT for ID Now and 93.7% (influenza/RSV) for Liat. The ID Now parallel workflow resulted in medians of 5.9 min for staffing, 9.7 min for walk-away and 15.6 min for TAT. Assuming prevalence of 20% influenza and 20% RSV, the ID Now sequential workflow resulted in medians of 9.4 min for staffing, 17.4 min for walk-away, and 27.1 min for TAT.ConclusionsThe ID Now and Liat systems offer different workflow characteristics. Key considerations for implementation include value of both influenza and RSV results, clinical setting, staffing capacity, and instrument(s) placement.

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“…[8] Furthermore, studies suggest that antibiotic use, morbidity, and mortality are higher among RSV-positive than influenza-positive adult hospitalized patients [9-11] and RSV patients are more likely to need hospital re-admission. [12]…”

Section: Introductionmentioning

confidence: 99%

Molecular point-of-care testing for influenza A/B and respiratory syncytial virus: comparison of workflow parameters for the ID Now and cobas Liat systems

Young¹,

Phillips

Griego-Fullbright³

et al. 2019

Preprint

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Aims: Point-of-care (POC) tests for influenza and respiratory syncytial virus (RSV) offer the potential to improve patient management and antimicrobial stewardship. Studies have focused on performance; however, no workflow assessments have been published comparing POC molecular tests. This study compared the Liat and ID Now systems workflow, to assist end-users in selecting an influenza and/or RSV POC test. Methods: Staffing, walk-away, and turnaround time (TAT) of the Liat and ID Now systems were determined using 40 nasopharyngeal samples, positive for influenza or RSV. The ID Now system requires separate tests for influenza and RSV, so parallel (two instruments) and sequential (one instrument) workflows were evaluated. Results: The ID Now ranged 4.1-6.2 minutes for staffing, 1.9-10.9 minutes for walk-away and 6.4-15.8 minutes for TAT per result. The Liat ranged 1.1-1.8 minutes for staffing, 20.0-20.5 minutes for walk-away and 21.3-22.0 minutes for TAT. Mean walk-away time comprised 38.0% (influenza positive) and 68.1% (influenza negative) of TAT for ID Now and 93.7% (influenza/RSV) for Liat. The ID Now parallel workflow resulted in medians of 5.9 minutes for staffing, 9.7 minutes for walk-away, and 15.6 minutes for TAT. Assuming prevalence of 20% influenza and 20% RSV, the ID Now sequential workflow resulted in medians of 9.4 minutes for staffing, 17.4 minutes for walk-away, and 27.1 minutes for TAT. Conclusions: The ID Now and Liat systems offer different workflow characteristics. Key considerations for implementation include value of both influenza and RSV results, clinical setting, staffing capacity, and instrument(s) placement.

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Respiratory syncytial virus infection among adults during influenza season: A frequently overlooked diagnosis

Cited by 12 publications

References 22 publications

Etiology of viral respiratory tract infections in hospitalized adults, and evidence of the high frequency of prehospitalization antibiotic treatment in Norway

Etiology of viral respiratory tract infections in hospitalized adults, and evidence of the high frequency of prehospitalization antibiotic treatment in Norway

Molecular point-of-care testing for influenza A/B and respiratory syncytial virus: comparison of workflow parameters for the ID Now and cobas Liat systems

Molecular point-of-care testing for influenza A/B and respiratory syncytial virus: comparison of workflow parameters for the ID Now and cobas Liat systems

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