Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: A genetic background?

Tapia, Lorena I.; Ampuero, Sandra; Palomino, María Angélica; Luchsinger, Vivían; Aguilar, Nelson; Ayarza, Eliana; Mamani, Rossana; Larrañaga, Carmen

doi:10.1016/j.meegid.2012.12.030

Cited by 14 publications

(10 citation statements)

References 66 publications

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“…2 By the age of 2 years, nearly all children have been infected with RSV at least once, yet only 1-3% develop a severe disease requiring hospitalization, 2,3 suggesting a genetic predisposition to develop a severe disease. [4][5][6][7][8][9] In agreement with this possibility, a twin cohort study revealed a higher concordance in the hospitalization rates of identical twins when compared to fraternal twins, estimating that approximately 20% of the propensity to develop severe bronchiolitis upon RSV infection was attributable to genetic differences. 10 The potential relevance of genetic background to the degree of severity of bronchiolitis is further reinforced by the differences in the rate of RSV hospitalization observed in populations from different racial and ethnic backgrounds living in the same geographic region or country.…”

Section: Introductionmentioning

confidence: 73%

Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients

et al. 2019

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BACKGROUND: Single-nucleotide polymorphisms (SNPs) that impact on the differential expression of interleukin 28B (IL28B) are implicated in the progression of viral-induced diseases. In this prospective longitudinal cohort study, we evaluated the association between IL28B SNPs rs12979860 and rs8099917 and the clinical outcome of bronchiolitis in pediatric patients. METHODS: A total of 682 infants suffering from bronchiolitis, categorized based on the final clinical outcome as mild or severe, were genotyped for IL28B SNPs rs12979860 and rs8099917. RESULTS: When infants were categorized exclusively based on the final clinical outcome, no association was established between IL28B SNPs and the severity of bronchiolitis. However, when stratified by sex, the homozygotes for the minor alleles of rs12979860 (T) and rs8099917 (G) were associated with a mild disease in girls but not in boys. CONCLUSION: SNPs rs12979860 and rs8099917 correlate with the severity of bronchiolitis and display a sex bias, where GG rs8099917 and TT rs12979860 genotypes are associated with a mild disease in girls but not in boys. These findings suggest that innate immunity and female sex links with the outcome of the diseases induced by respiratory viruses, such as RSV.

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Section: Introductionmentioning

confidence: 73%

Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients

et al. 2019

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“…Multiple studies have shown that the RSV G protein triggers the expression of the Th2 cytokines IL-13, IL-5, and IL-4 in mice and human cells, promoting eosinophilia and Th2 immunopathology (10, 67, 73). Genetic association studies in cohorts of children from China, Korea, Chile, and the Netherlands showed that gain of function variants in the IL4 promoter (−590T and −589T) (26, 56, 173) or in the IL-4 receptor alpha chain gene (Q551R) (56, 149) were associated with higher susceptibility to RSV. Likewise, a large study in a German cohort found an association between the IL-13 promoter variant −1112T and severity of RSV disease (124).…”

Section: Respiratory Syncytial Virusmentioning

confidence: 99%

Human Genetic Determinants of Viral Diseases

et al. 2017

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Much progress has been made in the identification of specific human gene variants that contribute to enhanced susceptibility or resistance to viral diseases. Herein we review multiple discoveries made with genome-wide or candidate gene approaches that have revealed significant insights into virus–host interactions. Genetic factors that have been identified include genes encoding virus receptors, receptor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins. We discuss a range of pathogenic viruses, including influenza virus, respiratory syncytial virus, human immunodeficiency virus, human T cell leukemia virus, human papilloma virus, hepatitis B and C viruses, herpes simplex virus, norovirus, rotavirus, parvovirus, and Epstein-Barr virus. Understanding the genetic underpinnings that affect infectious disease outcomes should allow tailored treatment and prevention approaches in the future.

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“…Some single nucleotide polymorphisms (SNPs) have been identified to be associated with respiratory tract infections and asthma or airway hyperreactivity, including picornavirus with atopic asthma and airway hyperreactivity, and RSV with atopic asthma and airway hyperreactivity . A cohort study of children with RSV demonstrated that genes coding for the Interleukin (IL) pathway, specifically IL4 which might promote allergic inflammation and asthma, are associated with both RSV infection and wheezing, suggesting a potential role for genetic differences in immune responses to infections . The immune system could also be an explaining factor in the associations of the microbiome with asthma and wheezing.…”

Section: Influencing Factorsmentioning

confidence: 99%

The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review

Meel

Jaddoe

Bønnelykke

et al. 2017

Pediatric Pulmonology

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Asthma is a common disease in childhood, and might predispose for chronic obstructive respiratory morbidity in adolescence and adulthood. Various early-life risk factors might influence the risk of wheezing, asthma, and lower lung function in childhood. Cohort studies demonstrated that lower respiratory tract infections in the first years of life are associated with an increased risk of wheezing and asthma, while the association with lung function is less clear. Additionally, the gut and airway microbiome might influence the risk of wheezing and asthma. The interaction between respiratory tract infections and the microbiome complicates studies of their associations with wheezing, asthma, and lung function. Furthermore, the causality behind these observations is still unclear, and several other factors such as genetic susceptibility and the immune system might be of importance. This review is focused on the association of early-life respiratory tract infections and the microbiome with wheezing, asthma, and lung function, it is possible influencing factors and perspectives for future studies.

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Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: A genetic background?

Cited by 14 publications

References 66 publications

Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients

Correlation between female sex, IL28B genotype, and the clinical severity of bronchiolitis in pediatric patients

Human Genetic Determinants of Viral Diseases

The role of respiratory tract infections and the microbiome in the development of asthma: A narrative review

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