Respiratory Syncytial Virus Surveillance in the United States, 2007–2012

McGuiness, Catherine Balderston; Boron, Marnie L.; Saunders, Brett; Edelman, Laurel; Kumar, Veena R.; Rabon-Stith, Karma M.

doi:10.1097/inf.0000000000000257

Cited by 31 publications

(34 citation statements)

References 14 publications

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“…In Northern Europe, IAV epidemics are concentrated in the winter months, and the peak is usually in February [14]. RSV epidemics occur simultaneously with IAV, and the peak is in February, but with a wider time span [14,15]. Our results were in concordance with these reports: the IAV peak was commonly detected between weeks 7 and 9, whereas the annual RSV peak had a wider range (from week 7 in 2012 to week 14 in 2014).…”

Section: Discussionsupporting

confidence: 91%

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Comprehensive real-time epidemiological data from respiratory infections in Finland between 2010 and 2014 obtained from an automated and multianalyte mariPOC® respiratory pathogen test

Gunell

Antikainen²,

Porjo³

et al. 2016

Eur J Clin Microbiol Infect Dis

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Respiratory viruses cause seasonal epidemics every year. Several respiratory pathogens are circulating simultaneously and typical symptoms of different respiratory infections are alike, meaning it is challenging to identify and diagnose different respiratory pathogens based on symptoms alone. mariPOC® is an automated, multianalyte antigen test which allows the rapid detection of nine respiratory infection pathogens [influenza A and B viruses, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, parainfluenza 1-3 viruses and pneumococci] from a single nasopharyngeal swab or aspirate samples, and, in addition, can be linked to laboratory information systems. During the study period from November 2010 to June 2014, a total of 22,485 multianalyte respi tests were performed in the 14 participating laboratories in Finland and, in total, 6897 positive analyte results were recorded. Of the tested samples, 25 % were positive for one respiratory pathogen, with RSV (9.8 %) and influenza A virus (7.2 %) being the most common findings, and 0.65 % of the samples were multivirus-positive. Only small geographical variations in seasonal epidemics occurred. Our results show that the mariPOC® multianalyte respi test allows simultaneous detection of several respiratory pathogens in real time. The results are reliable and give the clinician a picture of the current epidemiological situation, thus minimising guesswork.

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Section: Discussionsupporting

confidence: 91%

“…For example, IAV and RSV circulation shows a wave-like pattern, whereas adenovirus is present throughout the year. It is also commonly known that RSV causes larger epidemics biannually [15,20], which could also be seen in our material: RSV was detected more frequently in samples in 2012 and 2014 compared to 2013 ( Table 2 and Fig. 3).…”

Section: Discussionsupporting

confidence: 85%

Comprehensive real-time epidemiological data from respiratory infections in Finland between 2010 and 2014 obtained from an automated and multianalyte mariPOC® respiratory pathogen test

Gunell

Antikainen²,

Porjo³

et al. 2016

Eur J Clin Microbiol Infect Dis

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“…In a study conducted in Egypt by Shafik et al [5] aiming to identify the relative prevalence of various respiratory viruses that contribute to LRTIs in young children under five years of age, RSV was determined to be the predominant viral agent among children with LRTI using RT-PCR; also, RSV could only be detected from November through midFebruary. Another study by McGuiness et al [15] estimating the RSV season in the United States by the Centers for Disease Control and Prevention found that the RSV season onset occurred in October/November of each year with an offset occurring in March/April of the following year. Also, Leung et al [16] found that RSV-associated PICU admissions in Hong Kong appeared to follow the overall pattern of RSV outbreaks, which usually begin in November or December, peak in January or February, and end by the end of March or sometime in April.…”

Section: Discussionmentioning

confidence: 99%

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Othman

Elhamed

Hassan

et al. 2016

J Infect Dev Ctries

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Introduction: Viruses are the most important causative agents of acute lower respiratory tract infections (ALRTIs), ranked as the second leading cause of death and the primary cause of hospitalization in children. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are among the commonest viral causes of severe ALRTI. In this study, we aimed to study the burden of both RSV and hMPV in causing severe ALRTI in children younger than two years of age admitted to the pediatric intensive care unit (PICU). Methodology: Nasopharyngeal swabs were collected from children admitted to the PICU with a diagnosis of community-acquired ALRTI who were two years of age or younger. Real-time polymerase chain reaction (RT-PCR) was used to test for RSV and hMPV. Results: A total of 127 swabs were screened for RSV and hMPV, of which 49.6% were negative for RSV and hMPV, 46.4% were positive for RSV, and 3.9% were positive for hMPV. With respect to RSV, the mean age of cases (4.01 ± 5.05) and the monthly distribution (mainly January) were the most important risk factors. There were no statistically significant differences between the RSV group and control group regarding duration of hospital stay, mechanical ventilation need or duration, and underlying chronic conditions. Conclusions: RSV is important viral cause of severe ALRTIs in children younger than two years of age during this study period; hMPV played a minor role.

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“…RSV tests were conducted for all study weeks from 2001 to 2013. For this study, the RSV outbreak periods were defined as consecutive MMWR weeks with at least 10% positive diagnostic tests, as has been done in past studies [2,3]. The same criterion, that is, consecutive weeks with at least 10% positive tests, was used to define the flu outbreak periods in order to maintain a consistent approach for the 2 respiratory viruses.…”

Section: Surveillance Datamentioning

confidence: 99%

“…Respiratory syncytial virus (RSV) is a well-recognized, common cause of severe lower respiratory tract illness and hospitalization in children [1]. More recently, the contribution of adult RSV infections to the utilization of advanced healthcare resources, morbidity, and mortality has become increasingly clear [2][3][4][5][6][7]. Introduction of diagnostic real-time reverse-transcription polymerase chain reaction assays for viral testing has improved identification of RSV infections and increased awareness of the prominent role this respiratory virus has in relatively severe illness in adults [5,6,8,9].…”

mentioning

confidence: 99%

Severe Illnesses Associated With Outbreaks of Respiratory Syncytial Virus and Influenza in Adults

Zhou

Schweinle

Lichenstein

et al. 2019

Clinical Infectious Diseases

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Background. Recent reports have described the contribution of adult respiratory syncytial virus (RSV) infections to the use of advanced healthcare resources and death.Methods. Data regarding patients aged ≥18 years admitted to any of Maryland's 50 acute-care hospitals were evaluated over 12 consecutive years (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013). We examined RSV and influenza (flu) surveillance data from the US National Respiratory and Enteric Virus Surveillance System and the Centers for Disease Control and Prevention and used this information to define RSV and flu outbreak periods in the Maryland area. Outbreak periods consisted of consecutive individual weeks during which at least 10% of RSV and/or flu diagnostic tests were positive. We examined relationships of RSV and flu outbreaks to occurrence of 4 advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation, and death) due to medically attended acute respiratory illness (MAARI).Results. Occurrences of all 4 MAARI-related hospital advanced medical outcomes were consistently greater for all adult ages during RSV, flu, and combined RSV-flu outbreak periods compared to nonoutbreak periods and tended to be greatest in adults aged ≥65 years during combined RSV-flu outbreak periods. Rate ratios for all 4 MAARI-related advanced medical outcomes ranged from 1.04 to 1.38 during the RSV, flu, or combined RSV-flu outbreaks compared to the nonoutbreak periods, with all 95% lower confidence limits >1.Conclusions. Both RSV and flu outbreaks were associated with surges in MAARI-related advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation, and death) for adults of all ages.

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Respiratory Syncytial Virus Surveillance in the United States, 2007–2012

Cited by 31 publications

References 14 publications

Comprehensive real-time epidemiological data from respiratory infections in Finland between 2010 and 2014 obtained from an automated and multianalyte mariPOC® respiratory pathogen test

Comprehensive real-time epidemiological data from respiratory infections in Finland between 2010 and 2014 obtained from an automated and multianalyte mariPOC® respiratory pathogen test

Respiratory syncytial virus and human metapneumovirus in severe lower respiratory tract infections in children under two

Severe Illnesses Associated With Outbreaks of Respiratory Syncytial Virus and Influenza in Adults

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