Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak, Aneta; Szturmowicz, Monika; Kuś, Jan

doi:10.5603/arm.2017.0028

Cited by 10 publications

(5 citation statements)

References 93 publications

(234 reference statements)

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“…Skin lesions and respiratory symptoms, which are typical for allergic diseases, occur also in the course of IBD. However, they are much less frequent [39].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of allergic diseases in children with inflammatory bowel disease

Wasielewska¹,

Dolińska²,

Wilczyńska³

et al. 2019

pdia

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Introduction There are many similarities between inflammatory bowel disease (IBD) and allergic diseases, including similar epidemiological data, pathomechanism, clinical course and even treatment methods. So far, many studies of IBD comorbidity with other diseases, including allergy, but mainly in adults, have been conducted. Aim To analyse the prevalence of allergic diseases, i.e. food allergy (FA), cow’s milk allergy (CMA), atopic dermatitis (AD), allergic rhinitis (AR) and asthma in children with IBD. Material and methods The study included 105 IBD patients from the Department of Paediatrics, Allergology and Gastroenterology of Collegium Medicum in Bydgoszcz and 100 children without IBD from the Outpatient Clinics. The authors applied the validated questionnaire as a study method. Results At least one allergic disease was found in 26 (43%) IBD children. The allergological diagnosis was made in IBD children more frequently than in the control group ( p = 0.04). The difference was more noticeable with regards to skin prick tests ( p = 0.02). FA was the most common disease; it was noted in 19 (32%) IBD children; followed by: AD – in 13 (22%), CMA – in 12 (20%), AR – in 10 (17%) and asthma – in 6 (10%) children. The prevalence of allergic diseases in the control and study groups was comparable ( p > 0.05). There was no correlation between age of IBD children and allergy ( p > 0.05). Asthma was significantly more common in children undergoing biological treatment ( p = 0.01). Conclusions Children with IBD should be constantly monitored by medical professionals, not only due to the underlying disease but also due to a possible concomitant allergic disease.

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“…Skin lesions and respiratory symptoms, which are typical for allergic diseases, occur also in the course of IBD. However, they are much less frequent [39].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of allergic diseases in children with inflammatory bowel disease

Wasielewska¹,

Dolińska²,

Wilczyńska³

et al. 2019

pdia

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“…Case 2 was pathologically identified as organizing pneumonia, which is the most commonly observed type of parenchymal lung lesion in IBD [ 12 , 13 ]. Other parenchymal lung lesions (e.g., necrotic nodules, interstitial pneumonia, lymphocytic interstitial pneumonia, and eosinophilic pneumonia) have been reported, and the phenotype of these lesions varies [ 8 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary manifestation of inflammatory bowel disease: Two case reports

Suzuki,

Noro,

Omori

et al. 2023

Respiratory Medicine Case Reports

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“…Although some researchers have pointed to the possible correlation between the duration of IBD, and HRCT findings, no relationship was finally stated between them. The analysis of numerous clinical cases shows a higher number of respiratory complications with an increase in the duration of IBD exacerbations [57]. It should also be noted that although the systemic lesions in the respiratory system can occur in any age, the female gender is more predisposed.…”

Section: Respiratory Tract Complicationsmentioning

confidence: 98%

Non–necrotizing Inflammatory Granulomas (N-Ngs) in the Course of Inflammatory Bowel Disease – Immunology and Clinical Manifestation of Intestinal and Respiratory N-NGS

et al. 2020

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The aim:The article describes and summarizes the immunological pathomechanisms controlling the development of non-necrotizing granulomas in the course of non-specific inflammatory bowel diseases (IBD) in lungs and intestines; it also reviews the possible clinical correlations between the processes in the gastrointestinal and respiratory tracts based on the example of Crohn’s disease (CD) and non-specific inflammatory bowel disease (IBC). While the dominant cell subpopulation in ulcerative colitis (UC) is Th2, which produces interleukins IL-4, IL-5, IL-6, IL-10 and IL-13 and Th17 cells; CD characterized by the Th1 cell subpopulation and macrophages predominate, producing IL-23. These are considered to be the key factors crucial for the occurrence of chronic inflammation. Another important causative factor of non-specific inflammatory bowel diseases and granulation is the expression of CD40/CD40L proteins on activated T-cells, i.e. type 2 transmembrane proteins similar to TNF-alpha. However, the interactions between gastrointestinal neuroendocrine peptides/amines (NEPA) and the immune system are believed to have a significant influence on the pathophysiology of non-specific inflammatory bowel diseases and non-necrotizing granulation. The key functions of the immune response of the gastrointestinal tract are managed by the neuroendocrine regulatory system (NES) whose activities govern the production of various hormones including chromogranin/secretogranin, serotonin, vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), substance P, somatostatin or ghrelin.

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Respiratory System Involvement in Inflammatory Bowel Diseases

Abstract: Inflammatory bowel diseases are systemic disorders that can manifest in any location. The problem of respiratory system involvement is very important form clinical point of view. In the article we try to systematize the current knowledge on this topic.

Cited by 10 publications

References 93 publications

Prevalence of allergic diseases in children with inflammatory bowel disease

Prevalence of allergic diseases in children with inflammatory bowel disease

Pulmonary manifestation of inflammatory bowel disease: Two case reports

Non–necrotizing Inflammatory Granulomas (N-Ngs) in the Course of Inflammatory Bowel Disease – Immunology and Clinical Manifestation of Intestinal and Respiratory N-NGS

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