This investigation aims to study contemporary literature pertaining to the involvement of hyaluronate in the pathogenesis of diverse medical conditions, encompassing coronavirus-induced pulmonary injury, while also exploring its potential utility as a prognostic indicator for assessing the severity of COVID-19. This study conducted a comprehensive examination of hyaluronic acid’s multifaceted role in physiological processes and disease, with a specific focus on its implications in COVID-induced lung damage. The research provided an in-depth analysis of the intricate mechanisms and fundamental patterns governing these biological phenomena, elucidating essential interactions and pathways. Of particular significance in this investigation was the potential diagnostic utility of hyaluronic acid in assessing the severity of acute respiratory distress syndrome (ARDS), including COVID-19. Through a rigorous examination of hyaluronic acid concentration levels, researchers sought to assess its potential as an early prognostic indicator, thereby providing valuable insights for clinical diagnostics. Furthermore, the study explored the therapeutic prospects related to hyaluronic acid, emphasizing its involvement in various pathological processes. It suggested that targeting hyaluronic acid could represent a promising avenue for drug development, potentially leading to the creation of innovative pharmaceutical agents