Respiratory tract mortality in cement workers: a proportionate mortality study

Rachiotis, George; Drivas, Spyros; Κostikas, Κonstantinos; Makropoulos, Vasilios; Hadjichristodoulou, Christos

doi:10.1186/1471-2466-12-30

Cited by 12 publications

(14 citation statements)

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“…For lung cancer mortality, the pattern of SMRs was similar to that seen for all cancers with four of the seven studies reporting SMRs with CIs overlapping the null, two studies showing slightly decreased SMRs (SMR=0.53, 95% CI 0.27 to 0.95)12 and (SMR=0.56, 95% CI 0.32 to 0.89),6 and one reporting an increase for lung cancer (n=85 cases; PMR=2.05, 95% CI 1.65 to 2.627; figure 2). The meta-SMR for lung cancer mortality was 0.93 (95% CI 0.62 to 1.39).…”

Section: Resultssupporting

confidence: 68%

“…8 10 12 33 The meta-SMR for colon and rectal cancer mortality was 1.05 (95% CI 0.79 to 1.40). Cement work was not associated with significant increases or decreases in pancreas cancer mortality in two studies (SMR=1.01, 95% CI 0.43 to 1.98) and (SMR=0.80, 95% CI 0.36 to 1.60)8 12 or with bladder cancer mortality in two studies (SMR=1.10, 95% CI 0.44 to 2.43) and (PMR=1.52, 95% CI 0.85 to 2.55) 7 8…”

Section: Resultsmentioning

confidence: 84%

“…The meta-SMR for lung cancer mortality was 0.93 (95% CI 0.62 to 1.39). Mortality from cancer of the larynx was non-significant in the only two studies reporting on this site (SMR=1.32, 95% CI 0.53 to 2.74)7 and (SMR=0.59, 95% CI 0.19 to 1.52) 8…”

Section: Resultsmentioning

confidence: 92%

“…Half of the studies of all cancers combined reported CIs overlapping the null5 10 12 while two others showed slightly decreased SMRs for all cancers for cement workers (SMR=0.80, 95% CI 0.69 to 0.92)8 and (SMR=0.64, 95% CI 0.48 to 0.82),6 and one showed a slight increase (PMR=1.30, 95% CI 1.13 to 1.49) 7. The meta-SMR for all cancers combined was 0.94 (95% CI 0.76 to 1.16).…”

Section: Resultsmentioning

confidence: 99%

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A review and meta-analysis of cancer risks in relation to Portland cement exposure

et al. 2014

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Workers engaged in the production of Portland cement may come into contact with potential occupational hazards, but existing epidemiological studies show wide variation in risk estimates for cancer incidence and mortality in relation to cement exposure. This report identified studies of cement workers and associations with cancer incidence and mortality in a systematic review and meta-analysis. A systematic review according to the PRISMA guidelines was conducted to identify studies of Portland cement workers and cancer outcomes. Meta-analyses were performed using random effects models for all cancers combined and for each cancer site with three or more reported measures of risk. A total of 26 studies were included in the review (14 occupational cohort studies and 12 case-control studies). Overall, the meta-relative risks did not provide convincing evidence for increased risks of any cancers in relation to cement exposure. Meta-SMR and 95% CIs were 0.94 (0.76 to 1.16) for six studies reporting all cancers combined, 0.93 (0.62 to 1.39) for seven studies reporting on lung cancer, 1.07 (0.72 to 1.59) for five studies reporting on stomach cancer, and 1.05 (0.79 to 1.40) for four studies reporting on colorectal cancer. Meta-relative risks for cancer incidence were similarly null for all sites with the exception of colorectal cancer which had a borderline statistically significant elevated risk (SIR=1.38, 95% CI 1.02 to 1.88). Overall, the meta-relative risks calculated across 26 published studies do not provide evidence of increased risks for cancer in relation to cement exposure.

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Section: Resultssupporting

confidence: 68%

Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

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A review and meta-analysis of cancer risks in relation to Portland cement exposure

et al. 2014

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“…The relation between lung cancer and occupational exposure to cement remains inconclusive and controversial where other studies showed negative relationship. 35 Moreover, this study revealed that 16.3% of cases were farmers (Table 1); of them 34.4% had LCC, 15.4% had SCC and 7.9% had ADC (Table 4). This finding might be possibly point out the relation between farming environment and an increased risk of bronchogenic carcinoma.…”

Section: Occupational Risk Factorsmentioning

confidence: 73%

Characteristics, risk factors and histopathological types of bronchogenic carcinoma among cases presented to Chest Department, Al-Zahraa Hospital, Al-Azhar University

Abo-Elkheir

Hafez

2018

Int J Community Med Public Health

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Background: Recently, lung cancer representing 5-7% of all cancers in Egypt with unavailable accurate epidemiological data. This study aims to identify characteristics, risk factors and histopathological types of bronchogenic carcinoma among a group of Egyptian patients.Methods: A cross sectional study was conducted on 123 cases of histopathological confirmed bronchogenic carcinoma presented to chest diseases department, Al-Zahraa Hospital, Al-Azhar University, Egypt in the period from July 2013 to May 2017. Statistical analysis of patients’ database was done using SPSS version 17.Results: Male to female ratio was 3.2:1; the majority of cases presented in their fifth (55.3%) and sixth (29.3%) decades of life, and urban: rural residence ratio was 2.1:1. Smoking was the most significant risk factor among 93.5% of cases, among them 65.9% were current smokers, 13.0% were ex-smokers and 14.6% were passive smokers. Occupational exposure to cement dust were reported among 47.2% of cases, 16.3% were farmers, 13.0% were employees, 8.9% were house wives, 8.1% were shoe makers and 6.5% were drivers. COPD was reported among 54.5% of cases. The commonest histopathological types were squamous cell carcinoma (31.7%), adenocarcinoma (30.9%), and large cell carcinoma (26.0%). Adenocarcinoma was the predominant type among females (55.3%), passive smokers (31.6%) and non-smokers (15.8%).Conclusions: Small cell lung cancer and squamous cell carcinoma subtypes were predominant among males, active smokers and workers exposed to cement dust. Adenocarcinoma was the commonest type among females, passive smokers and non-smokers. Conduction of anti-smoking campaigns; reduction of environmental pollution with regulation of occupational exposures to cement dust are recommended.

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Altered methylation in tandem repeat element and elemental component levels in inhalable air particles

Hou

Zhang

Zheng

et al. 2013

Environ and Mol Mutagen

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Exposure to particulate matter (PM) has been associated with lung cancer risk in epidemiology investigations. Elemental components of PM have been suggested to have critical roles in PM toxicity, but the molecular mechanisms underlying their association with cancer risks remain poorly understood. DNA methylation has emerged as a promising biomarker for environmental-related diseases, including lung cancer. In this study, we evaluated the effects of PM elemental components on methylation of three tandem repeats in a highly-exposed population in Beijing, China. The Beijing Truck Driver Air Pollution Study was conducted shortly before the 2008 Beijing Olympic Games (June 15-July 27, 2008) and included 60 truck drivers and 60 office workers. On two days separated by 1-2 weeks, we measured blood DNA methylation of SATα, NBL2, D4Z4, and personal exposure to eight elemental components in PM2.5, including aluminum (Al), silicon (Si), sulfur (S), potassium (K), calcium (Ca) titanium (Ti), iron (Fe), and zinc (Zn). We estimated the associations of individual elemental component with each tandem repeat methylation in generalized estimating equations (GEE) models adjusted for PM2.5 mass and other covariates. Out of the eight examined elements, NBL2 methylation was positively associated with concentrations of Si (0.121, 95%CI: 0.030; 0.212, FDR=0.047) and Ca (0.065, 95%CI: 0.014; 0.115, FDR=0.047) in truck drivers. In office workers, SATα methylation was positively associated with concentrations of S (0.115, 95%CI: 0.034; 0.196, FDR=0.042). PM-associated differences in blood tandem-repeat methylation may help detect biological effects of the exposure and identify individuals who may eventually experience higher lung cancer risk.

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Respiratory tract mortality in cement workers: a proportionate mortality study

Cited by 12 publications

References 14 publications

A review and meta-analysis of cancer risks in relation to Portland cement exposure

A review and meta-analysis of cancer risks in relation to Portland cement exposure

Characteristics, risk factors and histopathological types of bronchogenic carcinoma among cases presented to Chest Department, Al-Zahraa Hospital, Al-Azhar University

Altered methylation in tandem repeat element and elemental component levels in inhalable air particles

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