Respiratory Viral Infections in Transplant Recipients

Liu, Catherine; Ho, Dora Y.; Boeckh, Michael

doi:10.1007/978-1-4939-9034-4_40

Cited by 5 publications

(5 citation statements)

References 205 publications

(271 reference statements)

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“…6 Kim et al 22 showed that both hostrelated and transplant-related factors seem to determine the risk of progression to LRTIs more than viral factors for progressive RSV disease. 23 In our study, 73% of the infections were limited to URTIs, whereas 27% progressed to LRTIs. Progression to LRTIs occurred most commonly in cases of COVID-19 infection.…”

Section: Discussionmentioning

confidence: 44%

“…Risk factors for progression to LRTIs include older age, lymphopenia (≤200 cells/µL), alternative or nongenoidentical sibling donor, myeloablative conditioning, and chronic GVHD 6. Kim et al22 showed that both host-related and transplant-related factors seem to determine the risk of progression to LRTIs more than viral factors for progressive RSV disease 23. In our study, 73% of the infections were limited to URTIs, whereas 27% progressed to LRTIs.…”

Section: Discussionmentioning

confidence: 46%

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Respiratory Viral Infections in the Pediatric Hematopoietic Stem Cell Transplant Population

Yenigürbüz

Atay

Akinci

et al. 2022

Journal of Pediatric Hematology/Oncology

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Background: Respiratory viral infections (RVIs) are important complications in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT); however, risk factors for lower respiratory tract infections (LRTIs) are not well characterized. The aim of this study was to determine risk factors for the progression to LRTIs in pediatric patients with respiratory symptoms who underwent HSCT. Patients and Methods: This retrospective study included 87 pediatric patients with respiratory symptoms who underwent HSCT. Respiratory viral polymerase chain reaction samples were obtained from all patients. The evaluated data included risk factors to progression to LRTIs, long-term pulmonary complications, transplantation-related mortality, and overall survival. Results: Viral pathogens were detected in 31 (48.4%) patients with upper respiratory tract infections and 13 (56.5%) patients with LRTIs. There was a statistically significant difference between the groups in engraftment delay and lymphocytopenia. Also it was determined that engraftment delay (odds ratio: 7.46 [95% CI, 1.99 to 27.86]; P = 0.003) and COVID-19 infection had statistically significant effects on overall survival in general (odds ratio: 8.06 [95% CI, 2.63 to 24.64]; P <0.001]). Conclusion: Not only host and transplant-related factors but also viral agent type were found to be effective in progression to LRTIs. As the available therapy for respiratory viral infections remains limited, the focus should be on the prevention of infection.

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Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 46%

Respiratory Viral Infections in the Pediatric Hematopoietic Stem Cell Transplant Population

Yenigürbüz

Atay

Akinci

et al. 2022

Journal of Pediatric Hematology/Oncology

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“…Adults with underlying chronic lung disease, congenital heart disease, and immunodeficiency are more likely to experience severe disease [ 6 , 7 ]. RSV infection has been linked with high mortality rates in patients who have undergone lung or bone marrow transplants [ 8 ]. Therefore, developing a preventative measure through vaccination is quite important.…”

Section: Introductionmentioning

confidence: 99%

Immunogenicity of a recombinant plant-produced respiratory syncytial virus F subunit vaccine in mice

Pisuttinusart,

Shanmugaraj,

Srisaowakarn

et al. 2024

Biotechnology Reports

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“…Viral respiratory infections (RVIs) are among the most common infections after allo-HSCT. In recipients, RVIs occur in 8-22% in the first 100 days after transplantation with high differences between countries, wards, transplant strategies and outpatient-concepts (2). The common pathogens for RVIs include the influenza virus, the parainfluenza virus (PIV), the respiratory syncytial virus (RSV), the human metapneumovirus (HMPV), the human coronavirus (HCoV) and the human rhinovirus (HRV).…”

Section: Introductionmentioning

confidence: 99%

“…A high frequency of infections might trigger a reduction of systemic immunosuppression to potentially improve the patient's immune system, which in turn may result in higher rates of GvHD further leading to a vicious circle of infectious pneumonia and aggravating GvHD and the development of bronchiolitis obliterans syndrome resulting in airflow obstruction (2,9). Before the pandemic, in case of respiratory symptoms isolation has been mandatory and early PCR-based testing using nasal/throat swabs was used.…”

Section: Introductionmentioning

confidence: 99%

The impact of FFP2 masking on medical wards for allogeneic hematopoietic stem cell transplantation: Retrospective analysis for future guidance

Richardson,

Holtick,

Scheid

et al. 2023

Preprint

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Patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT) are highly susceptible to infections. The use of masks on wards for allo-HSCT has been controversial in the past decades and was not common before the covid-19 pandemic. We retrospectively compared incidence and outcomes of viral respiratory infections during allo-HSCT on our specialized ward between 2018 – 2020 to the era of FFP2 masking between 2021 – 2023 covering similar seasons of the year. Each group consisted of 150 matched patients. The usage of FFP2 masks reduced the incidence of viral respiratory infections from 22,1% to 2,1% (p < 0.005). This reduced the time on ward from a median of 26 days to 23,5 days (p = 0,002). It also resulted in less use of CT-scans (p = 0.003) and bronchoalveolar lavage procedures (p = 0,057). Median time to proof of infection was 21 days after admission in both groups. No difference was detected in progression free survival, hospital survival or non-relapse mortality (p = 0,78). Our retrospective results indicate that FFP2 masks worn by patients and hospital staff significantly reduce the incidence of viral respiratory infections, including covid-19, shorten the time spent in hospital and reduce costs without affecting survival.

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Respiratory Viral Infections in Transplant Recipients

Cited by 5 publications

References 205 publications

Respiratory Viral Infections in the Pediatric Hematopoietic Stem Cell Transplant Population

Respiratory Viral Infections in the Pediatric Hematopoietic Stem Cell Transplant Population

Immunogenicity of a recombinant plant-produced respiratory syncytial virus F subunit vaccine in mice

The impact of FFP2 masking on medical wards for allogeneic hematopoietic stem cell transplantation: Retrospective analysis for future guidance

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