Respiratory virus and asthma: The role of immunoglobulin E

Khan, Sadia Hayat; Park, Stephanie S.; Sirajuddin, Iram A.; Grayson, Mitchell H.

doi:10.1016/j.clinthera.2008.06.002

Cited by 13 publications

(9 citation statements)

References 49 publications

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“…CCL28 is a human chemokine that has been shown to be an important player in the development of allergic airway inflammation and asthma (21,31,32). In this study we provide additional evidence linking CCL28 to the development of chronic asthma pathology.…”

Section: Discussionsupporting

confidence: 59%

Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma

Thomas

Buelow

Nevins

et al. 2015

Journal of Biological Chemistry

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Background: CCL28 is associated with the pathogenesis of acute post-viral asthma. Results: In the absence of viral infection, natively folded CCL28 can induce asthma pathology, whereas unfolded CCL28 cannot. Conclusion:The structure of CCL28 is critical for its role in asthma pathogenesis. Significance: Inhibition of CCL28 presents a novel therapeutic option for the prevention of post-viral asthma.

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Section: Discussionsupporting

confidence: 59%

Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma

Thomas

Buelow

Nevins

et al. 2015

Journal of Biological Chemistry

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“…It would be wise to determine, using conventional or SPF piglets, whether a correlation exists between virus-specific IgA and prevention of PMWS. The role of the profoundly expanded IgE clones in PCV2 infection is more difficult to explain, although some studies indicate that some viruses act like parasites and elevate IgE response [59]. In all of these cases there is a need to determine if elevation of a particular isotype parallels the increase in specific Abs.…”

Section: Discussionmentioning

confidence: 99%

The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2

Šinkora

Butler

Lager

et al. 2014

Vet Res

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Lymphocyte subsets isolated from germ-free piglets experimentally infected with swine influenza virus (SIV), porcine reproductive and respiratory syndrome virus (PRRSV) or porcine circovirus type 2 (PCV2) were studied and the profile of these subsets among these three infections was monitored. Germ-free piglets were used since their response could be directly correlated to the viral infection. Because SIV infections are resolved even by colostrum-deprived neonates whereas PRRSV and PCV2 infections are not, SIV was used as a benchmark for an effectively resolved viral infection. PRRSV caused a large increase in the proportion of lymphocytes at the site of infection and rapid differentiation of B cells leading to a high level of Ig-producing cells but a severe reduction in CD2—CD21+ primed B cells. Unlike SIV and PCV2, PRRSV also caused an increase in terminally differentiated subset of CD2+CD8α+ γδ cells and polyclonal expansion of major Vβ families suggesting that non-specific helper T cells drive swift B cell activation. Distinct from infections with SIV and PRRSV, PCV2 infection led to the: (a) prevalence of MHC-II+ T cytotoxic cells, (b) restriction of the T helper compartment in the respiratory tract, (c) generation of a high proportion of FoxP3+ T cells in the blood and (d) selective expansion of IgA and IgE suggesting this virus elicits a mucosal immune response. Our findings suggest that PRRSV and PCV2 may negatively modulate the host immune system by different mechanisms which may explain their persistence.Electronic supplementary materialThe online version of this article (doi:10.1186/s13567-014-0091-x) contains supplementary material, which is available to authorized users.

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“…Among the highest up-regulated was Ccl28, a chemokine secreted by epithelial cells and a chemoattractant to T and B lymphocytes bearing the Ccr10 receptor. Ccl28 has also been mechanistically linked to dendritic cells, through a pathway which generates IgE and the high-affinity Fcε receptor, in addition to Ccl28 (Khan et al, 2008). The suggestion here is that increased numbers of T- and B-lymphocytes and dendritic cells might be present in the brains of the developmentally Pb exposed mice.…”

Section: Discussionmentioning

confidence: 99%

Developmental lead effects on behavior and brain gene expression in male and female BALB/cAnNTac mice

et al. 2012

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Lead (Pb) was one of the first poisons identified, and the developing nervous system is particularly vulnerable to its toxic effects. Relatively low, subclinical doses, of Pb that produce no overt signs of encephalopathy can affect cognitive, emotional, and motor functions. In the present study, the effects of developmental Pb-exposure on behavioral performance and gene expression in BALB/cAnNTac mice were evaluated. Pups were exposed to Pb from gestational-day (gd) 8 to postnatal-day (pnd) 21 and later evaluated in exploratory behavior, rotarod, Morris water maze, and resident-intruder assays as adults. Pb-exposure caused significant alterations in exploratory behavior and water maze performance during the probe trial, but rotarod performance was not affected. Pb-exposed males displayed violent behavior towards their cage mates, but not to a stranger in the resident-intruder assay. Gene expression analysis at pnd21 by microarray and qRT-PCR was performed to provide a molecular link to the behavior changes that were observed. Pb strongly up-regulated gene expression within the signaling pathways of mitogen activated protein kinases (MAPKs), extra-cellular matrix (ECM) receptor, focal adhesion, and vascular endothelial growth-factor (VEGF), but Pb down-regulated gene expression within the pathways for glycan structures-biosynthesis 1, purine metabolism, and N-glycan biosynthesis. Pb increased transcription of genes for major histocompatibility (MHC) proteins, the chemokine Ccl28, chemokine receptors, IL-7, IL7R, and proteases. The qRT-PCR analysis indicated an increase of gene expression in the whole brain for caspase 1 and NOS2. Analysis of IL-1β, caspase 1, NOS2, Trail, IL-18 and IL-33 gene expression of brain regions indicated that Pb perturbed the inter-regional expression pattern of pro-inflammatory genes. Brain region protein concentrations for IL-10, an anti-inflammatory cytokine, showed a significant decrease only within the cortex region. Results indicate that Pb differentially affects the behavior of male and female mice in that females did less exploration and the males were selectively more aggressive. Gene expression data pointed to evidence of neuroinflammation in the brain of both female and male mice. Pb had more of an effect in the males on expression of vomeronasal receptor genes associated with odor detection and social behavior.

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Respiratory virus and asthma: The role of immunoglobulin E

Cited by 13 publications

References 49 publications

Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma

Structure-Function Analysis of CCL28 in the Development of Post-viral Asthma

The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2

Developmental lead effects on behavior and brain gene expression in male and female BALB/cAnNTac mice

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