Respiratory viruses, a common microbiological finding in neutropenic children with fever

Lindblom, Anna; Bhadri, Vivek; Söderhäll, Stefan; Öhrmalm, Lars; Wong, Michelle; Norbeck, Oscar; Lindau, Cecilia; Rotzén-Östlund, Maria; Allander, Tobias; Catchpoole, Daniel; Dalla‐Pozza, Luciano; Broliden, Kristina; Tolfvenstam, Thomas

doi:10.1016/j.jcv.2009.11.026

Cited by 62 publications

(68 citation statements)

References 17 publications

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“…6,9,[18][19][20] Most studies have focused on RVs, 21,22 suggesting that they tend to be more severe in immunocompromised patients. 23,24 In Chile, a previous study 21 3,26,27 in this study, were detected mostly as RV coinfections.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia

Torres¹,

Labraña

Ibáñez

et al. 2012

Pediatric Infectious Disease Journal

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RVIs were the most frequently detected agents irrespective of their initial risk assessment for IBI. The clinical outcome of mixed RVI was similar to sole RVI episodes as well as for bacterial infections compared with mixed viral-bacterial infections. Systematic and early detection of RVI in children with cancer and FN might help to optimize their management by reducing hospitalization and antimicrobial use.

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Section: Discussionmentioning

confidence: 99%

Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia

Torres¹,

Labraña

Ibáñez

et al. 2012

Pediatric Infectious Disease Journal

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“…9 In a similar study on 90 children, a total of two (2.2%) were B19-positive. 10 The incidence of 30% in the study by Rahiala et al 2 was remarkably higher, but studies on other hematological pediatric patients, non-HSCT though, support their data. 4 Although the reported incidences from studies on allogeneic HCST recipients vary and although there are case reports of severe B19 infections, the clinical impact seems low in this patient category.…”

mentioning

confidence: 85%

Human parvovirus B19 in pediatric and adult recipients of allogeneic hematopoietic stem cell transplantation

Öhrmalm

Gustafson

Lindblom

et al. 2013

Bone Marrow Transplant

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“…[12][13][14][15][16][17] Numerous case series investigating respiratory viruses in hospitalized children with ARI have been published. [18][19][20] However, data are available from only a few case-control studies that examined to what extent specific respiratory viruses cause disease. 12,14,15,21 Furthermore, these studies had limitations in that they used hospital-based control subjects, which might have biased the results.…”

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confidence: 99%

Clinical Utility of PCR for Common Viruses in Acute Respiratory Illness

et al. 2014

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WHAT'S KNOWN ON THIS SUBJECT: Quantitative real-time polymerase chain reaction allows sensitive detection of respiratory viruses. The clinical significance of detection of specific viruses is not fully understood, however, and several viruses have been detected in the respiratory tract of asymptomatic children. WHAT THIS STUDY ADDS:Our results indicate that quantitative real-time polymerase chain reaction is limited at distinguishing acute infection from detection in asymptomatic children for rhinovirus, bocavirus, adenovirus, enterovirus, and coronavirus. abstract BACKGROUND: Acute respiratory illness (ARI) accounts for a large proportion of all visits to pediatric health facilities. Quantitative real-time polymerase chain reaction (qPCR) analyses allow sensitive detection of viral nucleic acids, but it is not clear to what extent specific viruses contribute to disease because many viruses have been detected in asymptomatic children. Better understanding of how to interpret viral findings is important to reduce unnecessary use of antibiotics. OBJECTIVE:To compare viral qPCR findings from children with ARI versus asymptomatic control subjects.METHODS: Nasopharyngeal aspirates were collected from children aged #5 years with ARI and from individually matched, asymptomatic, population-based control subjects during a noninfluenza season. Samples were analyzed by using qPCR for 16 viruses. RESULTS:Respiratory viruses were detected in 72.3% of the case patients (n 5 151) and 35.4% of the control subjects (n 5 74) (P 5 .001). Rhinovirus was the most common finding in both case patients and control subjects (47.9% and 21.5%, respectively), with a population-attributable proportion of 0.39 (95% confidence interval: 0.01 to 0.62). Metapneumovirus, parainfluenza viruses, and respiratory syncytial virus were highly overrepresented in case patients. Bocavirus was associated with ARI even after adjustment for coinfections with other viruses and was associated with severe disease. Enterovirus and coronavirus were equally common in case patients and control subjects.CONCLUSIONS: qPCR detection of respiratory syncytial virus, metapneumovirus, or parainfluenza viruses in children with ARI is likely to be causative of disease; detection of several other respiratory viruses must be interpreted with caution due to high detection rates in asymptomatic children. Although acute respiratory illness (ARI) in childrenaccountsfora large part ofall visits to pediatric health facilities and is a great economic burden on society, 1,2 our tools to diagnose the etiologic agents have until recently been limited. 3 Treatment with antibiotics induces development of antibiotic resistance in bacteria 4 and has a negligible effect on most ARIs, which generally are of viral origin. 5,6 Nevertheless, antibiotics are frequently prescribed due to lack of clinically valid diagnostic tests verifying a viral etiology. 7 Sensitive methods, such as quantitative real-time polymerase chain reaction (qPCR) analyses on nasopharyngeal samples, for a number of viru...

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Respiratory viruses, a common microbiological finding in neutropenic children with fever

Cited by 62 publications

References 17 publications

Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia

Frequency and Clinical Outcome of Respiratory Viral Infections and Mixed Viral-bacterial Infections in Children With Cancer, Fever and Neutropenia

Human parvovirus B19 in pediatric and adult recipients of allogeneic hematopoietic stem cell transplantation

Clinical Utility of PCR for Common Viruses in Acute Respiratory Illness

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