Respiratory viruses among pediatric inpatients with acute lower respiratory tract infections in Jinan, China, 2016–2019

Chu, Fulu; Li, Chen; Chen, Li; Dong, Bo; Qiu, Yang; Liu, Yiqing

doi:10.1002/jmv.27875

Cited by 8 publications

(3 citation statements)

References 43 publications

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“…In a Chinese study, RSV was the most common virus and 58.3% of the patients requiring PICU care had underlying comorbidities. 22 In our study, 57.5% of patients had comorbidities. In a study evaluating the hospitalization of patients who were positive for influenza, RSV, and PIV, patients aged under 1 year were more frequently hospitalized, those aged over 5 years of age were mainly treated as outpatients.…”

Section: Discussionmentioning

confidence: 48%

Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic

Evren¹,

Besci²,

Appak

et al. 2023

J Pediatr Infect Dis

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This study aimed to determine the epidemiology and acute respiratory distress syndrome (ARDS) propensity of common respiratory viruses in a tertiary pediatric intensive care unit (PICU) among hospitalized children who were tested for respiratory viruses by polymerase chain reaction (PCR) prior to the coronavirus disease 2019 (COVID-19) pandemic. Respiratory tract samples were collected from patients who were followed up in the Dokuz Eylul University Hospital pediatric intensive care unit between March 2015 and March 2020 and tested for viral pathogens. The results of 269 patients between 1 month and 18 years of age were evaluated retrospectively. In the 5 years preceding the COVID-19 pandemic, 269 patients with a lower respiratory infection were admitted to the PICU. A positive viral PCR result was detected in 160 patients (59.5%). Human rhinovirus was the most common virus (40%), followed by respiratory syncytial virus (26.3%), human bocavirus (10%), and seasonal coronaviruses (10%). Five (33.3%) of the fifteen children who developed ARDS were infected with influenza A/B, while four (26.7%) were infected with human metapneumovirus (hMPV).Although rhinovirus was the most common viral agent in critically ill children, the incidence of ARDS was higher in children aged over 1 year who had influenza or hMPV infection.

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Section: Discussionmentioning

confidence: 48%

Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic

Evren¹,

Besci²,

Appak

et al. 2023

J Pediatr Infect Dis

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“…Respiratory syncytial virus (RSV), influenza viruses, parainfluenza viruses (PIV), adenoviruses, human rhinovirus (hRV), hMPV, HBoV, coronaviruses, and picornaviruses are the main viral etiological agents of ARTIs in all age groups" [21,22]. RSV, hMPV, hRV, and PIV are the most common among them and are seasonal illnesses that can occur with or without co-infection in children under the age of five [23].…”

Section: Aetiology Of Artismentioning

confidence: 99%

A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections

Narayanan

Nandagopal²,

Ramamurthy³

et al. 2023

AJRID

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One of the significant causes of morbidity and mortality among young children in developing nations is acute respiratory tract infections (ARTIs). It is also highly contagious, widely prevalent, and transmissible from person to person. It risks young children, the elderly, and those with immune system disorders. Acute respiratory infections are thought to cause 2.6 million child deaths annually worldwide, according to the World Health Organization (WHO) [1]. Infections in children with human metapneumovirus (hMPV) and bocavirus (HBoV) are linked to a high prevalence of ARTIs. It has been determined that hMPV is the second-leading cause of infant bronchiolitis, after the respiratory syncytial virus (RSV), of upper and lower respiratory tract infections. Although HBoV was first discovered in children's airways, the high detection rates of other viral pathogens and the discovery of HBoV in stool raise doubts about the virus's significance in respiratory tract infections. According to the published literature, only a few studies have identified ARTIs or demonstrated the importance of early diagnosis and treatment of ARTIs. This review article aims to thoroughly explain the aetiology, epidemiology, clinical characteristics, diagnostic approaches, and management of hMPV and HBoV.

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“…Respiratory virus or atypical pathogens are the major cause of ARIs. The predominant viruses that caused ARIs in children are respiratory syncytial virus and the influenza virus [ 5 , 6 , 7 , 8 ]. Vitamin D is well known for its important role in bone and calcium stabilization [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxy Vitamin D Levels in Children with Acute Respiratory Infections Caused by Respiratory Virus or Atypical Pathogen Infection

et al. 2023

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We aimed to clarify the involvement of vitamin D status in virus or atypical pathogens infection in children with acute respiratory infections (ARIs). In this retrospective study, 295 patients with ARIs were attacked by a respiratory virus or a single atypical pathogen; 17 patients with ARIs induced by two pathogens, and 636 healthy children were included. Serum 25(OH)D levels of all children were measured. Oropharyngeal samples of the patients for viruses or atypical pathogens were studied by polymerase chain reaction (PCR) or reverse transcription-polymerase chain reaction (RT-PCR). In our studies, 58.98% of the 295 single-infected subjects and 76.47% of the 17 co-infected subjects had 25(OH)D levels below the recommended 50.0 nmol/L; the mean 25(OH)D levels were 48.48 ± 19.91 nmol/L and 44.12 ± 12.78 nmol/L. Low serum 25(OH)D levels were remarkable in patients with one of seven viruses or atypical pathogens infected. These results were significantly different from those in the healthy group. There were no significant differences in 25(OH)D levels between single infection and co-infection groups. There were no differences in severity among means of 25(OH)D levels. Female or >6-year-old children patients with low serum 25(OH)D levels were more vulnerable to pathogenic respiratory pathogens. However, serum 25(OH)D levels may be related to the recovery of ARIs. These findings provide additional evidence for the development of strategies to prevent ARIs in children.

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Respiratory viruses among pediatric inpatients with acute lower respiratory tract infections in Jinan, China, 2016–2019

Cited by 8 publications

References 43 publications

Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic

Epidemiology and Acute Respiratory Distress Syndrome Propensity of Viral Respiratory Infections in Pediatric Intensive Care Units Prior to the Coronavirus Disease 2019 Pandemic

A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections

Serum 25-Hydroxy Vitamin D Levels in Children with Acute Respiratory Infections Caused by Respiratory Virus or Atypical Pathogen Infection

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