Respiratory viruses and chronic rejection in lung transplant recipients

Billings, Joanne

doi:10.1016/s1053-2498(01)00405-3

Cited by 189 publications

(168 citation statements)

References 6 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…Identification of the virus-driven mediators of subsequent allograft dysfunction is critical because evidence indicates that the true burden of viral infections on chronic allograft dysfunction is still underappreciated. Previous studies have captured recipients with viral infections retrospectively and therefore may have underestimated the true incidence of viral infection (7,34). Prospective protocols to track viral symptoms and identify virus with polymerase chain reaction-based assays have demonstrated a much higher incidence of respiratory viral infection (0.66-1.56 infections per patient-year of follow-up) (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

IL-12 p80 Is an Innate Epithelial Cell Effector That Mediates Chronic Allograft Dysfunction

Mikols

Yan

Norris

et al. 2006

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: Bronchiolitis obliterans syndrome is the leading cause of chronic lung allograft dysfunction. We have demonstrated that respiratory viral infection is a bronchiolitis obliterans syndrome risk factor and virus-dependent injury induces expression of innate airway epithelial genes belonging to the interleukin (IL)-12 family. Thus, we hypothesized that epithelial cell IL-12 family members could mediate lung allograft dysfunction. Objectives: We used mouse and human allograft specimens to evaluate the role of epithelial cell IL-12 family members in allograft dysfunction associated with and without viral infection. Methods: Murine and human IL-12 family members were characterized and manipulated in allografts and then correlated with epithelial cell injury, immune cell accumulation, and collagen deposition. Results: In a mouse model of lung transplantation, concurrent viral infection and allogeneic transplantation increased epithelial injury and this was followed by exaggerated accumulation of macrophages and collagen deposition. This virus-driven allograft dysfunction was associated with an epithelial innate response manifested by a synergistic increase in the production of the macrophage chemoattractant IL-12 p80 (p80), but not IL-12 or IL-23. Blockade or overexpression of donor epithelial p80 resulted in a corresponding abrogation or enhancement of macrophage accumulation and allograft dysfunction. We extended these findings to human recipients with viral infection and transplant bronchitis and again observed excessive epithelial p80 expression that correlated with increased macrophage accumulation. Conclusions: These experiments support a role for an enhanced epithelial innate response as a central process in allograft dysfunction and identify the macrophage chemoattractant p80 as an innate epithelial effector of disease progression.

show abstract

Section: Discussionmentioning

confidence: 99%

IL-12 p80 Is an Innate Epithelial Cell Effector That Mediates Chronic Allograft Dysfunction

Mikols

Yan

Norris

et al. 2006

Am J Respir Crit Care Med

View full text Add to dashboard Cite

show abstract

“…Recently, data regarding parainfluenza virus infection in lung transplant recipients suggest a significant morbidity for this patient population (10)(11)(12)(13)(14). More importantly, studies indicate that this infection may have immediate and long-term implications for the function of the transplanted lung (10,(13)(14)(15). The aims of this review are to summarize the pathogenesis, the clinical features of parainfluenza virus infection in lung transplant recipients, and to evaluate the implications of this infection in this patient population.…”

Section: Introductionmentioning

confidence: 99%

Parainfluenza Virus Infection in Adult Lung Transplant Recipients: An Emergent Clinical Syndrome with Implications on Allograft Function

Vilchez

Dauber

McCurry

et al. 2003

American Journal of Transplantation

View full text Add to dashboard Cite

Parainfluenza virus is a common cause of seasonal upper respiratory tract infections in children and adults. Studies indicate that parainfluenza virus may play an important role in the etiology of respiratory tract infections in lung transplant recipients with an estimated incidence of 5.3 per 100 patients. Parainfluenza virus type 3 is the most frequent serotype in lung transplant patients. The rate of lower respiratory tract infections with parainfluenza virus among lung transplant recipients is between 10 and 66% of cases. In addition, trans-bronchial biopsy at the time of parainfluenza infection shows signs of acute allograft rejection. Subsequently, 32% of patients have been found to have active bronchiolitis obliterans at a median time of 6 months (range 1-14) postviral infection. These findings indicate that parainfluenza virus infections may have long-term implications for lung transplant recipients. Further studies are required to identify the mechanisms of immunomodulation of parainfluenza virus among these patients. In addition, controlled studies are needed to evaluate the efficacy of aerosolized ribavarin in the treatment of parainfluenza virus infection and to determine whether vaccines may be effective in these high-risk patients.

show abstract

“…Airway virus infection, ischemiaperfusion injury, human leukocyte antigen mismatching, and lymphocyte-epithelial interactions also are implicated. 4,19,20,[22][23][24] Unlike acute rejection, which reverses with increased immunosuppression, chronic OB/BOS responds poorly.…”

mentioning

confidence: 99%

Transcript Signatures of Lymphocytic Bronchitis in Lung Allograft Biopsy Specimens

Golden

Dolganov³

et al. 2005

The Journal of Heart and Lung Transplantation

View full text Add to dashboard Cite

show abstract

Respiratory viruses and chronic rejection in lung transplant recipients

Cited by 189 publications

References 6 publications

IL-12 p80 Is an Innate Epithelial Cell Effector That Mediates Chronic Allograft Dysfunction

IL-12 p80 Is an Innate Epithelial Cell Effector That Mediates Chronic Allograft Dysfunction

Parainfluenza Virus Infection in Adult Lung Transplant Recipients: An Emergent Clinical Syndrome with Implications on Allograft Function

Transcript Signatures of Lymphocytic Bronchitis in Lung Allograft Biopsy Specimens

Contact Info

Product

Resources

About