Respiratory Viruses and Other Relevant Viral Infections in the Lung Transplant Recipient

Abedi, Ali; Hall, Reed; Levine, Deborah J.

doi:10.1007/978-3-319-91184-7_15

Cited by 1 publication

(11 citation statements)

References 155 publications

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“…30,38,68 For influenza, evaluation of the seasonal onset of BOS correlates with influenza prevalence. 21,35,85 Ng et al studied the effect of the influenza H1N1 pandemic in Australia and found that 32% of patients had progression of BOS stage within 1 year after infection. 69 For adenovirus, in a cohort of mostly pediatric patients, Bridges et al identified adenovirus as a risk factor for both BOS development and death.…”

Section: Chronic Lung Allograft Dysfunctionmentioning

confidence: 99%

“…74 In contrast, influenza, RSV, and parainfluenza are more likely to present with symptoms including fever and are more likely to require hospitalization. 21,74,95,96 Prevention and treatment guidance for specific viruses follows (also see ►Table 2).…”

Section: Diagnosis Prevention and Treatmentmentioning

confidence: 99%

“…Influenza A and influenza B account for up to 5% of viral infections in LTRs. 21,97 In contrast to paramyxoviruses, serious disease related to influenza is less frequent in LTRs. Current guidelines recommend yearly immunization with inactivated vaccine (at least 3 months after transplant) and postexposure chemoprophylaxis with neuraminidase inhibitors (oseltamivir or zanamivir).…”

Section: Influenzamentioning

confidence: 99%

“…Older agents (M2 inhibitors amantadine and rimantadine) are no longer recommended due to resistance (influenza A) and inactivity (influenza B). 21,98 Respiratory Syncytial Virus…”

Section: Influenzamentioning

confidence: 99%

“…Coronaviridae are single-stranded RNA viruses that include various coronavirus strains including those causing severe adult respiratory distress syndrome (SARS) and SARS-CoV-2 infection/COVID-19. 20,21 In this article, we will review the effects of CARV infections on LTRs, including associations with acute and chronic allograft rejection, impact on mortality, and potential mechanistic links.…”

mentioning

confidence: 99%

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Community-Acquired Respiratory Viruses Post–Lung Transplant

Sweet

2021

Semin Respir Crit Care Med

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Survival in lung transplant recipients (LTRs) lags behind heart, liver, and kidney transplant, in part due to the direct and indirect effects of infection. LTRs have increased susceptibility to infection due to the combination of a graft continually exposed to the outside world, multiple mechanisms for impaired mucus clearance, and immunosuppression. Community-acquired respiratory viral infections (CARVs) are common in LTRs. Picornaviruses have roughly 40% cumulative incidence followed by respiratory syncytial virus and coronaviruses. Although single-center retrospective and prospective series implicate CARV in rejection and mortality, conclusive evidence for and well-defined mechanistic links to long-term outcome are lacking. Treatment of viral infections can be challenging except for influenza. Future studies are needed to develop better treatments and clarify the links between CARV and long-term outcomes.

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Section: Chronic Lung Allograft Dysfunctionmentioning

confidence: 99%

Section: Diagnosis Prevention and Treatmentmentioning

confidence: 99%

Section: Influenzamentioning

confidence: 99%

“…Older agents (M2 inhibitors amantadine and rimantadine) are no longer recommended due to resistance (influenza A) and inactivity (influenza B). 21,98 Respiratory Syncytial Virus…”

Section: Influenzamentioning

confidence: 99%

mentioning

confidence: 99%

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